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EMPRO
HIV/AIDS
Framework programme: 6
Call: 1
Project number:
LSHP-CT-2003-503558
EC contribution: € 11,800,000
Duration: 60 months
Type: IP
Starting date: 1 January 2004
Website: http://www.empro.org.uk
Graphic element European Microbicides project
Keywords: Microbicide; HIV; mucosal; infection; transmission; vaginal

Summary:

In view of the increasing numbers of new HIV infections each year, particularly in the developing world, there is an urgent need for additional measures to prevent the transmission of HIV infection. This project aims to develop new microbicide compounds to prevent HIV infection using technologies such as nanobodies, anticalins, peptide libraries and glyconanoparticles in addition to more traditional approaches. Following a rigorous selection procedure, the most promising candidates will be tested in a phase I clinical trial.

Background:

While condom use remains the most effective protection against sexual transmission of HIV, such protection requires partner consent. It is clear that in many areas of the world women are not empowered to negotiate condom use. Indeed the continual spread of the HIV-1 epidemic is testament to the lack of safe sex practices. The urgent need for novel strategies to block HIV-1 transmission in the absence of a protective vaccine has been the driving force behind the development of mucosal microbicides.

Aim:

To develop new topical microbicides that block entry of HIV at mucosal sites and, in achieving this, also establish a pipeline of candidate microbicides while taking selected microbicides through the phase I clinical trial.

Expected results:

This project is developing new microbicides using some novel approaches and technologies not previously applied to microbicide development. It is expected that the project will discover a range of new microbicides based on these technologies and that these microbicides will show these microbicides, methods for large-scale production will be investigated as will optimisation of mucosal formulations for delivery to the vagina. Finally the project will deliver phase I clinical testing of the most promising compounds and/or combinations.

Potential applications:

Ultimately, these microbicides may be used to prevent HIV infection in the developing world. This will require phase II and III clinical trials and additional support from industry and/or other interested parties.

Coordinators:

Charles Kelly
Department of Oral Immunology
GKT Dental Institute
Guy’s Hospital
SE1 9RT London
United Kingdom
Tel: +44 20 7188 4379
Fax: +44 20 7188 4375
E-mail: charles.kelly@kcl.ac.uk
Website: http://www.kcl.ac.uk

Robin Shattock
St George’s Hospital Medical School
Department of Infectious Disease
Cranmer Terrace
SW17 0RE London
United Kingdom
Tel: +44 20 8725 5855
Fax: +44 20 8725 3487
E-mail: Shattock@sghms.ac.uk
Website: http://www.sghms.ac.uk

Partners:

Principal
Scientific
Participants
Official Address Other Information
3Thomas LehnerMucosal Immunology Unit
GKT Dental Institute
Guy’s Hospital
UK-SE1 9RT London
United Kingdom
Tel: +44 20 7188 3065
Fax: +44 20 7188 4375
E-mail: Thomas.Lehner@kcl.ac.uk
Website: http://www.kcl.ac.uk
4Julian MaSt George’s Hospital Medical School
Department of Infectious Disease
Cranmer Terrace
UK-SW17 0RE London
United Kingdom
Tel: +44 20 8725 5818
Fax: +44 20 7188 4375
E-mail: jma@sghms.ac.uk
Website: www.sghms.ac.uk
5Jan Balzarini and Dominique ScholsRega Institute for Medical Research
Katholieke Universiteit Leuven
Minderbroedersstraat 10
BE-3000 Leuven
Belgium
Tel: +32 16 337352/73
Fax: +32 16 337340
E-mail:
jan.balzarini@rega.kuleuven.ac.be
Dominique.schols@rega.kuleuven.ac.be
Website: http://www.kuleuven.ac.be/rega
6Guy Van den MooterLaboratorium voor Farmacotechnologie en Biofarmacie
Katholieke Universiteit Leuven
Campus Gasthuisberg O+N
Herestraat 49
BE-3000 Leuven
Belgium
Tel: +32 16 345829
Fax: +32 16 345996
E-mail:
guy.vandenmooter@pharm.kuleuven.ac.be
Website: http://www.farm.kuleuven.ac.be/pharbio
7Morgane BomselInstitut Cochin
Université René Descartes – Paris V
22 rue Mechain
FR-75014 Paris
France
Tel: +33 1 40 51 64 97
Fax: +33 1 40 51 64 54
E-mail: Bomsel@cochin.inserm.fr
Website: http://www.cochin.inserm.fr
8Laurent BélecInstitut des Cordeliers
15 rue de l’Ecole de Médecine
FR-75006 Paris
France
Tel: +33 1 56 09 39 59
Fax: +33 1 56 09 24 47
E-mail: laurent.belec@u430.bhdc.jussieu.fr
Website: http://www.inserm.fr
9Colin CampionCarbohydrate Synthesis Ltd
Building 15
North Culham Estate
Culham Science Centre
Abingdon
UK-OX14 3GY Oxfordshire
United Kingdom
Tel: +44 1865 407767
Fax: +44 1865 407985
E-mail: ccampion@lineone.net
Website: http://www.carbohydratesynthesis.com
10Mario ClericiDepartment of Immunology
Milan University Medical School
Via GB Grassi 74
IT-20157 Milan
Italy
Tel: +39 02 5031 9679
Fax: +39 02 5031 9677
E-mail: mario.clerici@unimi.it
Website: http://www.unimi.it
11Hans de HaardAblynx N.V.
Technologiepark 4
BE-9052 Zwijnaarde
Belgium
Tel: +32 9 261 0631
Fax: +32 9 261 0627
E-mail: hans.dehaard@ablynx.com
Website: http://www.ablynx.com
12Stefano VellaDirector, Department of Drug Research and Evaluation
Istituto Superiore di Sanità (ISS)
Viale Regina Elena 299
IT-00161 Rome
Italy
Tel: +39 06 4990 6016 (direct) /
+39 06 4990 6015 (secretariat)
Fax: +39 06 4990 3661 (direct) /
+39 06 4990 2012 (secretariat)
Website: http://www.iss.it
13Charles LaceyThe University of York
Heslington
UK-YO10 5DD York
United Kingdom
Tel: +44 1904 725425
Fax: +44 1904 642116
E-mail: charles.lacey@hyms.ac.uk
Website: http://www.york.ac.uk
14Quentin
Sattentau
Sir William Dunn School of Pathology
University of Oxford
South Parks Road
UK-OX1 3RE Oxford
United Kingdom
Tel: +44 1865 275511
Fax: +44 1865 275515
E-mail:
quentin.sattentau@pathology.ox.ac.uk
Website: http://www.ox.ac.uk
15Claudio VitaProtein Engineering and Research Department
Commissariat à l’Energie Atomique Saclay
FR-91191 Gif-sur-Yvette
France
Tel: +33 1 69 08 71 33
Fax: +33 1 69 08 90 71
E-mail: vita@dsvidf.cea.fr
Website: http://www.cea.fr
16Roger Le GrandService de Neurovirolgie
Commissariat à l’Energie Atomique
18 route du Panorama
FR-92265 Fontenay-aux-Roses Cedex
France
Tel: +33 1 46 54 73 74
Fax: +33 1 46 54 77 26
E-mail: legrand@dsvidf.cea.fr
Website: http://www.cea.fr
17Elisa Vicenzi and Paolo LussoAIDS Immunopathogenesis Unit
Fondazione Centro San Raffaele del Monte Tabor
Via Olgettina n. 58
IT-20132 Milan
Italy
Tel: +39 02 2643 4908
Fax: +39 02 2643 4905
E-mail: vicenzi.elisa@hsr.it
18Karl MalcolmSchool of Pharmacy
The Queen’s University Belfast
97 Lisburn Road
UK-BT9 7BL Belfast
United Kingdom
Tel: +44 28 9097 2319
Fax: +44 28 9024 7794
E-mail: k.malcolm@qub.ac.uk
Website: http://www.qub.ac.uk
19Soledad PenadesInstituto de Investigaciones Quimicas
Consejo Superior de Investigaciones Cientificas
Americo Vespucio s/n
ES-41094 Seville
Spain
Tel: +34 95 4489561
Fax: +34 95 4460565
E-mail: penades@cica.es
Website: http://www.csic.es
20Rob MeloenPepscan Systems BV
Edelhertweg 15
NL-8219 PH Lelystad
The Netherlands
Tel: +31 320 237200
Fax: +31 320 238120
E-mail: r.h.meloen@pepscan.nl
Website: http://www.pepscan.nl
21Pasqua OresteGlycores 2000 s.r.l.
Via Mac Mahon 43
IT-20155 Milan
Italy
Tel: +39 02 3310 1771
Fax: +39 02 3453 4495
E-mail: oreste@glycores.it
Website: http://www.glycores.it
22Gianni PozziLaboratory of Molecular Microbiology and Biotechnology
Dipartmento di Biologia Molecolare
Università di Siena
Policlinico Le Scotte
1S Viale Bracci
IT-53100 Siena
Italy
Tel: +39 0577 233430
Fax: +39 0577 233334
E-mail: Pozzi@unisi.it
Website: http://www.unisi.it
23Arne SkerraLehrstuhl f. Biologische Chemie
Technische Universität München
DE-85350 Freising-Weihenstephan
Germany
Tel: +49 8161 71 4351
Fax: +49 8161 71 4352
E-mail: skerra@wzw.tum.de
Website: http://www.tu-muenchen.de
24Pieter Van der BijlFaculty of Health Sciences
University of Stellenbosch
Private Bag 19063
Tygerberg 7505
South Africa
Tel: +27 21 9389331
Fax: +27 21 9326958
E-mail: pvdb@sun.ac.za
Website: http://www.sun.ac.za
25Guido Vanham and Vicky JespersPrince Leopold Institute for Tropical Medicine
Nationalestraat 155
BE-2000 Antwerp 1
Belgium
Tel: +32 3 247 6228
Fax: +32 3 247 6231
E-mail:
gvanham@itg.be
vjespers@itg.be
Website: http://www.itg.be
26Pierre Roques and Pierre RouquetDepartment de Virologie
Centre International de Recherches Médicales de Franceville
BP769 Franceville
Gabon
Tel: +241 6770 92/62
Fax: +241 6772 95
E-mail: roques@cirmf.sci.ga
rouquet@cirmf.sci.ga
27Stephan
Grzesiek
Department of Structural Biology
Biozentrum
University of Basel
Klingelbergstr 70
CH-4056 Basel
Switzerland
Tel: +41 61 267 2100
Fax: +41 61 267 2109
Email: stephan.grzesiek@unibas.ch
Website: http://www.biozentrum.unibas.ch
28Robin WeissWindeyer Institute of Medical Sciences
University College London
46 Cleveland Street
UK-W1T 4JF London
United Kingdom
Tel: +44 20 7679 9554
Fax: +44 20 7679 9555
E-mail: r.weiss@ucl.ac.uk
Website: http://www.ucl.ac.uk
29Jens van RoeyTibotec BVBA
BE- 2800 Mechelen
Belgium
Tel: +32 15 401231
Fax: +32 15 293162
E-mail: jvroey@tibbe.jnj.com
30Ian JonesSchool of Animal and Microbial Sciences
University of Reading
Whiteknights
UK-RG6 6AH Reading
United Kingdom
Tel: +44 118 378 8902
Fax: +44 118 378 8902
E-mail: i.m.jones@reading.ac.uk
Website: http://www.rdg.ac.uk

 
 
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