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MALVECASIA
MALARIA
Framework programme: 5
Project number:
ICA4-CT-2002-10041
EC contribution: € 1 433 000
Duration: 40 months
Type: RS
Starting date: 1 September 2002
Graphic element Monitoring Insecticide Resistance and Mapping Malaria Vectors in Southeast Asia : A Prerequisite for Sustainable Malaria Vector Control

Summary:

New tools for improving sustainable control of malaria vectors in Southeast Asia will be developed. An adapted monitoring system to detect early development of insecticide resistance will be set up and molecular and biochemical tests will be developed to explore the resistance mechanisms involved. At the end of the project, the insecticide resistance status will be available for at least 120 sites, as will a decision tree for the management of operational implications. A geographical information system (GIS) on vector distribution (both primary and secondary vectors) and insecticide resistance will be developed. A model will developed to predict vector distribution and associations of species by environmental factors. This will be a practical tool to delineate malaria risk areas, to improve the targeting of vector control and assess the resistance status of vectors.

Objectives:

The objectives are:

1) to define the insecticide resistance status by (sibling) species in different physio-geographical regions of Southeast Asia
2) to study the operational implications of Malaria Control Programmes for the emergence and spread of insecticide resistance in malaria vectors
3) to explore the different mechanisms (insecticide metabolism, target-site resistance) involved in insecticide (cross) resistance
4) to determine the environmental determinants on vector distributions, associated disease risks and development of insecticide resistance in the region
5) to investigate the systematics/taxonomy of secondary vectors and establish their involvement in malaria transmission
6) to consolidate the research capacity of an existing network in Southeast Asia.

 

Description:

An improved monitoring system for the detection of insecticide resistance in malaria vectors will be set up and new, more appropriate tests will be developed. Bioassays, biochemical tests and molecular tests will be used to explore the resistance mechanisms involved. At the end of the project, the insecticide resistance status will be available for at least 120 sites and a decision tree for the management of operational implications will be set up. A geographical information system (GIS) on vector distribution (both primary and secondary vectors) and insecticide resistance will be developed. Existing data and data from the 120 different sites collected by the present project will be used. Integrated traditional and molecular systematic studies on secondary vectors will be implemented to resolve the identification of troublesome taxa and their taxonomic status. A model to predict vector distribution and associations of species by environmental factors will be developed. This will be a practical tool to delineate malaria risk areas, to improve the targeting of vector control and assessing the resistance status of vectors.

 

Milestones:

1. Resistance status of malaria vectors in Vietnam, Cambodia and Laos.
2. New tests to detect target site and metabolistic resistance in vectors.
3. Guidelines for an adapted insecticide resistance monitoring system.
4. Resolution of taxonomic identity of secondary malaria vectors.
5. A geographical information system for mapping anopheline distribution, insecticide resistance in relation to environmental factors, and a prediction model.

Coordinator:

Marc Coosemans
Instituut voor Tropische Geneeskunde
Department Parasitology
2000 Antwerp
Belgium
Tel: +32 3 247 6312
Fax: +32 3 247 6309
E-mail: marc.coosemans@itg.be

Partners:

  1. National Institute of Malaria, Parasitology and Entomology, Tu Liem, Hanoi, Vietnam
  2. Centre of Malariology, Parasitology and Entomology, Vientiane Municipality, Laos
  3. National Centre for Malaria Control, Parasitology and Entomology, Phnom Penh, Cambodia
  4. Faculty of Science, Mahidol University - Department of Biology, Bangkok, Thailand
  5. Liverpool School of Tropical Medicine, UK-Liverpool, United Kingdom
  6. Institut de Recherche pour le Dévelopment - Centre de Biologie et Gestion des Populations – IRD, FR-Montferrier sur Lez, France
  7. The Natural History Museum, London - Department of Entomology, Mosquitoes Programme, UK- London, United Kingdom

 
 
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