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AntiMal
MALARIA
Framework programme: 6
Call: 3
Project number:
LSHP-CT-2005-018834
EC contribution: € 17 750 000
Duration: 60 months
Type: IP
Starting date: 1 December 2005
Graphic element Development of New Drugs for the Treatment of Malaria
Keywords: Malaria; chemotherapy; drug development; drug discovery

Summary:

Leading groups of malaria researchers will integrate their expertise in malaria biology, chemotherapy and drug development to exploit new scientific and political opportunities to secure the development of a portfolio of viable novel antimalarial drugs. These new chemical entities will be commercially attractive to industrial partners and, through the generation of PPP’s, will result in affordable new antimalarial drugs registered to internationally recognised standards. The scientific programme of this IP will comprise complementary clusters of basic and applied scientific investigation, will build on the technology platforms generated by the BioMalPar NoE and will provide candidate molecules for clinical evaluation by the ‘European and Developing Countries Clinical Trials Partnership’ (EDCTP) programme. The IP will focus on the following areas: novel quinolines, novel peroxides, lipid targets, other targets and post candidate development. The project will bring together European research institutes of established international reputation in the field of malaria biology and chemotherapy, and their affiliated research groups in malaria-endemic areas. Through AntiMal’s programme of jointly executed research, 29 European research groups will support the network’s goals to generate viable lead drug molecules in collaboration with eight SMEs and four partners from malaria-endemic countries (including two SMEs). In addition to strengthening existing European excellence, increasing institutional integration and creating a durable structure of basic and applied malaria research in Europe with a focus on drugs, these activities will establish critical mass at the European level and integrate malaria specialists into a ‘virtual drug discovery and development’ structure with one focused scientific objective: the delivery of a new drug/s for malaria. The integration will provide international leadership, disseminate expertise and resources, provide training and mobility of scientists at all levels, and foster long-term collaborations that will strengthen European malaria research. A strong central management structure will be built around the core group of 33 institutions with contributions from 19 European countries, which will give opportunities for future participation from other EU and non-EU partners.

Background:

According to World Health Organisation statistics from the late 1990s, malaria kills 2.7 million people in Africa each year, and is responsible for enormous economic burdens in all the malaria-endemic regions. Ninety percent of those who die of malaria are African children under the age of five. Over 0.5 billion new infections occur annually and it has been estimated that the direct commercial cost of malaria in Africa alone is around € 3 billion per year. All of these figures are on the increase and a major contributor to this is the lack of effective, safe and affordable drugs to treat this disease.

 

Aim:

The goal is to establish a portfolio of new antimalarial drugs from within the European scientific community, and to manage this portfolio through an industry standard, pre-clinical evaluation and select candidates from within the portfolio for progression to ‘first into man’ studies. Ultimately this initiative will produce antimalarial drugs, registered to internationally recognised standards of excellence, which have potential utility in the affordable treatment of malaria within malaria-endemic countries and Europe.

 

Expected results:

It is expected that a portfolio of potential antimalarial drugs with at least two molecules from the portfolio will be developed to the point where ‘first into man’ studies can be conducted within the project time. The ultimate expectation is the registration of an affordable, safe and efficacious antimalarial drug/s for use in uncomplicated malaria.

 

Potential applications:

The function of the consortium is to establish a virtual drug discovery and development capacity in infectious disease with a focus on malaria within the European community and with southern partners. This capacity, and the expertise that will emerge from consortium activity, will have applications across a number of infectious diseases. The specific application of the outputs of this initiative will be through the development and registration of an antimalarial drug, followed by safe, affordable and effective treatment of uncomplicated malaria. There may also be potential applications for these products in malaria prophylaxis and in severe malaria.

Coordinator:

S A Ward
Liverpool School of Tropical Medicine, Molecular and Biochemical Parasitology
Pembroke Place
L3 5QA Liverpool

Tel: +44 151 705 3286
Fax: +44 151 705 3177
E-mail: saward@liv.ac.uk
Website: http://www.liv.ac.uk/lstm

Partners:

Principal
Scientific
Participants
Official Address Other Information
2
P O’Neil
University of Liverpool
Department of Chemistry
Crown Street
UK-L69 7ZD Liverpool
United Kingdom
Tel: +44 151 705 3553
Fax: +44 151 705 3588
E-mail: P.M.oneill01@liverpool.ac.uk
Website: http://www.liv.ac.uk
3
H Vial
Dynamique Moléculaire des Interactions Membranaires
Université Montpellier II
Place Eugene Batallion cc107
FR-34095 Montpellier, Cedex 5
France
Tel: +33 4 67 14 37 45
Fax: +33 4 67 14 42 86
E-mail: vial@univ-montp2.fr
Website: http://www.cnrs.fr
4
S Krishna
St George’s Hospital Medical School
Cellular and Molecular Medicine, Infectious Diseases
Cranmer Terrace
UK-SW17 0RE London
United Kingdom
Tel: +44 20 8725 5836
Fax: +44 20 8725 3487
E-mail: skrishna@sgul.ac.uk
Website: http://www.sghms.ac.uk
5
C Doerig
INSERM U609, Wellcome Centre for Molecular Parasitology
University of Glasgow
UK-G11 6NU Glasgow
United Kingdom
Tel: +44 141 339 8855 x 6201
Fax: +44 141 330 5422
E-mail: cdoer001@udcf.glas.ac.uk
Website: http://www.inserm.fr
6
D Taramelli
Istituto di Microbiologia
Universita degli Studi di Milano
Via Pascal 36
IT-20133 Milano
Italy
Tel: +39 02 5031 5071
Fax: +39 02 5031 5094
E-mail: donatella.taramelli@unimi.it
Website: http://www.unimi.it
7
M Lanzer
Universitatsklinikum Heidelburg
Hygiene-Institut / Abt. Parasitologie
Im Neuenheimer Feld 324
DE-69120 Heidelberg
Germany
Tel: +49 6221 567844
Fax: +49 6221 564643
E-mail: michael_lanzer@med.uni-heidelberg.de 
Website: http://med.uni-hd.de/
8
B Meunier
Centre National de la recherche
Scientifique
Laboratoire de Chimie de Coordination du CNRS
205 Route de Narbonne
FR-31077 Toulouse
France
Tel: +33 5 61 33 31 46
Fax: +33 5 61 55 30 03
E-mail: bmeunier@lcc-toulouse.fr
Website: http://www.cnrs.fr
9
D Monti
Institute of Molecular Science &
Technologies-CNR and Department of Organic & Industrial Chemistry
Via Golgi 19
IT-20133 Milan
Italy
Tel: +39 02 5031 4096
Fax: +39 02 5031 4072
E-mail: diego.monti@istm.cnr.it
Website: http://www.istm.cnr.it
10
A Thomas
Foundation Biomedical Primate Research Center
Department of Parasitology
PO Box 3306,
Lange Kleiweg 139
NL-2280GH Rijswijk
Netherlands
Tel: +31 15284 2699
Fax: +31 15284 3999
E-mail: thomas@bprc.nl
Website: http://www.bprc.nl
11
I Gilbert
University of Dundee
Biological Chemistry & Molecular
Microbiology, School of Life Sciences
MSI/WTB Complex, Dow Street
UK-DD1 5EH Dundee
United Kingdom
Tel: +44 1382 386240
Fax: +44 1382 348072
E-mail: i.h.gilbert@dundee.ac.uk
Website: http://www.dundee.ac.uk
12
D Gonzalez-Pacanowska
Instituto de Parasitología y Biomedicina ‘López Neyra’
Avenida del Conocimiento s/n. Pargue Tecnologico de Ciencias de la Salud
ES-18100 Armilla, Granada
Spain
Tel: +34 958 181 631
Fax: +34 958 181 632
E-mail: dgonzalez@ipb.csic.es
Website: http://www.csic.es
13
R Brun
Swiss Tropical Institute
Parasite Chemotherapy
Socinstrasse 57
CH-4002 Basel
Switzerland
Tel: +41 61 284 82 31
Fax: +41 61 271 86 54
E-mail: Reto.brun@unibas.ch
Website: http://www.sti.ch
14
K S Wilson
University of York
Heslington
UK-YO10 5DD York
United Kingdom
Tel: +44 1904 430 00
Fax: +44 1904 432 516
E-mail: keith@ysbl.york.ac.uk
Website: http://www.york.ac.uk
15
L Vivas
London School of Hygiene and Tropical Medicine
Keppel Street
UK-WC1E 7HT London
United Kingdom
Tel: +44 20 7927 2062
Fax: +44 20 7637 4314
E-mail: livia.vivas@lshtm.ac.uk
Website: http://www.lshtm.ac.uk
16
G Campiani
Università degli Studi di Siena
European Research Centre for Drug Discovery and Development (NatSynDrugs)
Via Aldo Moro
IT-53100 Siena
Italy
Tel: +39 0577 234172
Fax: +39 0577 234333
E-mail: campiani@unisi.it
Website: http://www.unisi.it
17
S Issifou
Laboratoire de Recherches
Hôpital Albert Schweitzer,
B.P.118,
Lambarene
Gabon
Tel: +241 58 10 99
Fax: +241 58 11 96
E-mail: isaadou2002@yahoo.fr
Website: http://www.lambarene.org
18
F J Mulaa
University of Nairobi
Department of Biochemistry
Riverside Drive, Chiromo Campus
PO Box 30197
Nairobi 00100
Kenya
Tel: +254 20 4442534
Fax: +254 20 4441186
E-mail: mulaafj@uonbi.ac.ke or mulaafj@yahoo.com
Website: http://www.uonbi.ac.ke
19
L Meijer
Station Biologique de Roscoff
Place George Teisser
FR-29682 Roscoff
France
Tel: +33 2 98 29 23 39
Fax: +33 2 98 29 23 42
E-mail: meijer@sb-roscoff.fr
Website: http://www.cnrs.fr
20
R Aman
African Centre for Clinical Trials
Suite One, Braham Court
State House Road
Nairobi 2288-00202
Kenya
Tel: +254 20 2733733
Fax: +254 20 2735564
E-mail: raman@africaonline.co.ke
21
A Kharazmi
LICA Pharmaceuticals A/S
Fruebjergvej-3
P O Box 5
DK-2100 Copenhagen
Denmark
Tel: +45 39179797
Fax: +45 39209792
E-mail: ak@licapharma.com
Website: http://www.licapharma.com
22
N G Johansson
Medivir AB
Research Strategy and Planning
Lunastigen 7
SE-14144 Huddinge
Sweden
Tel: +46 8 608 3115
Fax: +46 8 608 3199
E-mail: Nils.gunnar.johansson@medivir.se
Website: http://www.cnrs.fr
23
Dr D Vitt
4SC AG
Chemistry Collaborative Business
Am Klopferspitz 19a
DE-82152 Planegg-Martinsried
Germany
Tel: +49 89 7007630
Fax: +49 89 70076329
E-mail: daniel.vitt@4sc.com
Website: http://www.4sc.com
24
P Prakesh
COSMOS Limited
Lunga Lunga Road
Rangwe Close, Industrial Area
Nairobi 41433-00100
Kenya
Tel: +
254 20 550700-709; 554272
Fax: +
254 20 550680; 532948
E-mail: admin@cosmos-pharm.com
25
Ms Meunier-Chesny
PALUMED S A
Rue Pierre et Marie CURIE,
P O Box 28262
FR-31682 Laberge
France
Tel: +33 5 61 28 70 31
Fax: +33 5 61 28 70 35
E-mail: Palumed.dg@wanadoo.fr
Website: http://www.palumed.fr
26
A Scheer
Serono Pharmaceutical Research Institute
Biochemical Pharmacology Department
Chemin des Aulx 14,
Plan les Ouates
CH-1228 Geneva
Switzerland
Tel: +41 22 706 98 36
E-mail: Alexander.Scheer@serono.com
Website: http://www.serono.com
27
D Jabes
NeED Pharmaceuticals, Pharmacology
Via Volta 4
IT-22070 Cassina Rizzardi
Italy
Tel: +39 03 487869120
Fax: +39 03 1920477
E-mail: djabes@hotmail.com
28
H Jomaa
Justus-Liebig University Giessen
Institute for Biochemistry - Infectology
Ludwigstrasse 24
DE-35392 Giessen
Germany
Tel: +49 641 9947558
Fax: +49 641 9947579
E-mail: hassan.jomaa@uniklinikum-giessen.de
Website: http://www.uni-giessen.de
29
S Van Calenbergh
Faculteit Farmaceutische Wetenschappen / Laboratory for Medical Chemistry
Harelbekestraat 72
BE-9000 Gent
Belgium
Tel: +32 9 264 8124
Fax: +32 9 264 8146
E-mail: Serge.VanCalenbergh@UGent.be
Website: http://www.ugent.be
30
A Schlitzer
Ludwig-Maximilians-Universität München
Department Pharmazie
Butenandtstrasse 5 – 13
DE-81377 München
Germany
Tel: +49 89 2180 77804
Fax: +49 89 2180 79992
E-mail: martin.schlitzer@cup.uni-muenchen.de
Website: http://www.uni-muenchen.de
31
A Fokin
National Technical University of Ukraine, KPI
Department of Organic Chemistry
37 Peremoga Avenue
Kiev
Ukraine
Tel: +380 44 236 86 51
Fax: +380 44 236 97 74
E-mail: aaf@xtf.ntu-kpi.kiev.ua
Website: http://xtf.ntu-kpi.kiev.ua
32
D Elswijk
Kiadis B. V.
Zernikepark 6-8
Groningen
Netherlands
Tel: 31 50 5474270
Fax: +31 50 5474271
E-mail: d.vanelswijk@kiadis.com
Website: http://www.kiadis.com
33
F Jehl
Université Louis Pasteur
Institut de Bactériologie,
Laboratoire d’Antibiologie
FR-67000 Strasbourg
France
Tel: +33 3 90 24 37 81
Fax: +33 3 90 25 11 13
E-mail: francois.jehl@medecine.u-strasbg.fr

 
 
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