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MARK-AGE

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European Study to Establish Biomarkers of Human Ageing

Coordinator: Alexander BÜRKLE
Project Number: 200880
EC contribution: € 11,989,327.00
Project website: http://www.mark-age.eu/

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,700 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e.

  1. randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and
  2. subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified.
  3. A small number of patients with progeroid syndromes will also be included in the study.

A wide range of candidate biomarkers will be tested, including

  1. “classical” ones for which data from several smaller studies have been published;
  2. “new” ones, based on recent preliminary data, as well as
  3. “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants.

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