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DIABAT

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Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes

Coordinator: Stephan HERZIG
Project Number: 278373
EC contribution: € 5,999,998.00
Project website: http://www.diabat.org

The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes.

Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the DIABAT network (van Marken LIchtenbelt et al., N. Engl. J. Med. 360, 1500, 2009; Virtanen…, Enerbäck & Nuutila, N. Engl. J. Med. 360, 1518, 2009) along with sharp rise in insight in cellular, genetic, and regulatory mechanisms from animal studies.

Therefore, the DIABAT project aims at recruiting and re-activating endogenous energy-dissipating BAT as a preventive and/or remedial measure for weight and blood sugar control in obesity-related type 2 diabetes (“diabesity”), thereby halting or preventing destruction and facilitating recovery of pancreatic beta-cells under diabetic conditions.


Additional Information:

Professor Wouter van Marken Lichtenbelt talks about brown fat and the DIABAT project (German)




Professor Wouter van Marken Lichtenbelt talks about brown fat and the DIABAT project (Dutch)




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