Events

• Ruxandra DRAGHIA-AKLI ( 1.07MB)
  European Commission (15')
• Walter KOROSHETZ ( 717KB)
  NINDS, USA (15')
• Anthony PHILLIPS ( 1.98MB)
  CIHR, Canada (15')
• Carlos SEGOVIA PEREZ ( 2.54MB)
  Carlos III Institute, ES (15')
• Magali HAAS ( 2.13MB)
  One Mind for Research Campaign, USA (15')

Presentations will cover:

• State of play of research in respective countries
• Policy initiatives: presentation of previously set-up International Consortia and/or newly established Institutes, resources, databases
• What would they expect from the International Initiative for Traumatic Brain Injury Research?

(4 presentations of 15' + 30' for Q&A and/or discussion)

• David MENON - University of Cambridge
  Clinical bottlenecks: a report from two previous EU-NIH workshops ( 4.15MB)
• Ji-yao JIANG - Shanghai Jiaotong University School of Medicine
  Management of TBI: the need for a global approach ( 2.21MB)
• Marie-Noelle CASTEL - Sanofi-Aventis
  Why is industry withdrawing from the TBI field? ( 1.58MB)
• Mary BAKER - (EFNA)
  The needs of patients ( 684KB)

Discussion (30')
Chair: David MENON - University of Cambridge

Two previous EC-NIH workshops already identified urgent priorities, such as the need for a common database for sharing TBI patient data, for a large prospective study on a broad set of TBI patients to be able to revise diagnostic criteria and outcome measures, for understanding and validating best practices in TBI using CER analysis. These priorities will be the initial focus of the International Initiative. Are there other ones that should be addressed in the long term?

(5 presentations of 15' followed by 75 min discussion)

• Matt MCAULIFFE, NIH/CIT
  Progress in building a federated TBI database ( 1.88MB)
• Ramon DIAZ-ARRASTIA, NINDS
  How can lessons learned from ADNI be applied to TBI? ( 870KB)
• Andrew MAAS, University Hospital Antwerp
  Towards a standardized, open-access data collection for the TBI community: 1. Clinical data ( 2.35MB)
• Ian PIPER, Southern General Hospital, Glasgow
  Towards a standardized, open-access data collection for the TBI community: 2. ICU data ( 6.09MB)
• Alex VALADKA, University of Texas at Austin
  Beta-testing the Common Data Elements: Lessons learned from TRAC-TBI ( 1.89MB)

Discussion (75')
Chair: Sir Graham TEASDALE, University of Glasgow

What are the key research questions in TBI that can be addressed through a large, shared database? Which patient data should be collected? Should the database be openly available to the scientific community? What lessons can we learn from other successful databases (ADNI, NDAR, BRAIN-IT, TRACK-TBI etc)?

(4 presentations of 15' followed by 60 min discussion)

• Geoff MANLEY, UCSF
  Why we need to revise the current classification of TBI? ( 7.39MB)
• Ron HAYES, Banyan Biomarkers
  How biomarkers can inform TBI classification ( 5.85MB)
• Olli TENOVUO, FinBIRD
  A new way to use TBI biomarkers ( 2.46MB)
• Paul PARIZEL, Antwerp University Hospital
  New concepts in neuroimaging for TBI classification and monitoring ( 28.29MB)

Discussion (60')
Chair: Nino STOCCHETTI, University of Milan

What needs to be done to improve the current injury classification and patient stratification? What parameters (genotype, biomarkers, co-morbidities, neuroimaging etc.) should be monitored?

(4 presentations of 15' followed by 75 min discussion)

• Dik HABBEMA, Erasmus Medical Centre Rotterdam
  Benefits of Comparative Effectiveness Research in TBI ( 296KB)
• Steve WISNIEWSKI
  Research Design and Analysis Considerations for CER ( 108KB)
• Sir Graham TEASDALE, University of Glasgow
  TBI: Identifying and getting good practice into practice ( 364KB)
• Mike BELL, University of Pittsburgh
  Pediatric TBI issues that could be addressed by CER ( 1.10MB)

Discussion (75')
Chair: Geoffrey MANLEY, UCSF

What measures are needed to identify best practices in TBI? Would applying CER to TBI research help? Data from how many patients would be needed to power such a study? Which TBIs should be included? Which countries? Would the inclusion of developing countries patient cohorts be beneficial? What would be the realistic outcomes?

(4 presentations of 15' followed by 45 min discussion)

• John WHYTE, Moss Rehabilitation Research Institute
  Linking acute and post-acute research: conceptual overview ( 135KB)
• Nicole VON STEINBUECHEL, University of Göttingen
  Challenges in measuring outcome in TBI ( 1.28MB)
• Gale WHITENECK, Craig Hospital
  Linking acute and post-acute care research: recommendations from the Common Data Elements working group for TBI Outcomes ( 6MB)
• Ross ZAFONTE, Harvard University
  The impact of transitions in care on clinical studies ( 2.10MB)

Discussion (60')
Chair: John WHYTE, Moss Rehabilitation Research Institute

How do methods of characterizing patients, treatments, and outcomes change over time, and how can measures useful during the acute period be linked to measures that are useful in the post-acute period?

(90 min discussion) - 2 break out groups

1. Agencies representatives:
   Issues to be discussed include: governance structure, modalities for participating in the International Initiative, modalities of funding
2. Experts:
   Agree on recommendations for each session, propose volunteers for working groups (drafting of policy document that will become the backbone of the initiative).

(Each session chair rapidly summarises the main conclusion of his session - 10' each)

• Summary recommendations - Session I ( 402KB)
• Summary recommendations - Session II
• Summary recommendations - Session III ( 178KB)
• Summary recommendations - Session IV
• Summary recommendations - Session V