Navigation path

HIV VIROSOMES


HIV/AIDS

Development of a New Vaccine Against HIV: Virosomes Incorporating HIV proteins
Framework programme:
6
Call:
2
Project number:
LSHP-CT-2004-012183
EC contribution:
€ 973,930
Duration:
36 months
Type:
STREP
Starting date:
1 January 2005

Keywords: Vaccine; HIV; virosome

Summary:

A safe and effective vaccine is the only way to stop the spread of HIV, especially in developing countries. Despite enormous efforts of numerous groups, no convincing protective vaccine against HIV-1 has been generated so far. We suggest an alternative approach in HIV vaccine development: to test virus-like particles composed of primary HIV proteins or recombinant proteins with native conformation, which are incorporated into liposomes of the size of virions and with a lipid composition similar to the virus membrane. The aim of the project is to develop this concept from the laboratory to proof-of-concept studies in non-human primates.

We recently established a novel large-scale technology for generation of liposomes with desired properties and within this project will adapt this technology to incorporate HIV-1 proteins into liposomes, thereby stabilising their native conformation. Resulting virosomes carrying HIV proteins will be utilised as prophylactic and therapeutic vaccine against HIV-1 infection. Since this vaccine is cheap to produce, is stable and might be administered in a needle-free format, this approach ideally meets the specific needs of developing countries.

[+] Read More