Navigation path

EMPRO


HIV/AIDS

European Microbicides project
Framework programme:
6
Call:
1
Project number:
LSHP-CT-2003-503558
EC contribution:
€ 11,800,000
Duration:
60 months
Type:
IP
Starting date:
1 January 2004
Website:
-

Keywords: Microbicide; HIV; mucosal; infection; transmission; vaginal

Summary:

In view of the increasing numbers of new HIV infections each year, particularly in the developing world, there is an urgent need for additional measures to prevent the transmission of HIV infection. This project aims to develop new microbicide compounds to prevent HIV infection using technologies such as nanobodies, anticalins, peptide libraries and glyconanoparticles in addition to more traditional approaches. Following a rigorous selection procedure, the most promising candidates will be tested in a phase I clinical trial.

Background:

While condom use remains the most effective protection against sexual transmission of HIV, such protection requires partner consent. It is clear that in many areas of the world women are not empowered to negotiate condom use. Indeed the continual spread of the HIV-1 epidemic is testament to the lack of safe sex practices. The urgent need for novel strategies to block HIV-1 transmission in the absence of a protective vaccine has been the driving force behind the development of mucosal microbicides.

Aim:

To develop new topical microbicides that block entry of HIV at mucosal sites and, in achieving this, also establish a pipeline of candidate microbicides while taking selected microbicides through the phase I clinical trial.

[+] Read More