Navigation path



Development of a Malaria-Resistant DNA Chip as a Public Health Tool for the Management of Plasmodium Falciparum Malaria Drug Resistance
Framework programme:
Project number:
EC contribution:
€ 1 292 000
36 months
Starting date:
1 January 2003

Keywords: DNA chips; malaria; drug resistance


This project aims at evaluating a newly developed DNA micro array for drug resistance monitoring in affected areas. Results will allow the dynamics of drug resistance to be captured and to forecast its development by establishing a community-based genetic resistance index, providing tools for rational and evidence-based decisions on the optimal use of drugs. The relationship between in vivo drug sensitivity and in vitro susceptibility to several anti-malarials, and the prevalence of multiple SNPs providing correlates for clinical resistance will be assessed. Sequencing will identify additional informative codons.


The genetic diversity of malaria parasites is a major obstacle in the development of rational control strategies against this poverty related disease. Increase of health threatening drug resistance must be monitored and prevented to protect introduced drugs.


The aims of this project are:

  1. to develop a sensitive, standardised tool for large-scale molecular epidemiological studies on Plasmodium falciparum drug resistance based on a DNA chip detecting SNPs
  2. to further document nucleotide polymorphism of genes associated with drug resistance in field samples and develop novel markers
  3. to establish a genetic resistance index (GRI) in several malaria endemic sites all over the world
  4. to coordinate efforts of European molecular epidemiologists working in different field sites to achieve a worldwide multi-locus survey of genes involved in resistance against major anti-malarial drugs
  5. to transfer innovative, high throughput technology, and provide training to malaria endemic countries to establish efficient tools for drug policy decision-making.
[+] Read More