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MALTRANS


Malaria

Project Interruption of Malaria Transmission Vaccine Strategies
Framework programme:
5
Project number:
QLK2-CT-1999-00753
EC contribution:
€ 2 499 962
Duration:
36 months
Type:
RS
Starting date:
1 March 2000

Keywords: Transmission; blockade; vaccines; malaria

Summary:

Malaria is one of the major infectious diseases in the world with tremendous impact on quality of life. Malaria control is difficult and the available tools are limited. Vaccines designed for different stages of the parasite life cycle will be the only long-term and cost-effective tool to control this ever growing problem. Malaria vaccines aim at interruption of the life cycle of Plasmodium falciparum by vaccine-induced immune responses. The sexual stages of the cycle occur in the human host and in the mosquito vector, and are responsible for transmission and spread of the parasite in the population. Sexual stage vaccines aim at an arrest of the transmission and therefore spread or (re-)introduce the disease in a risk area.

Objectives:

The objectives are:
  • the production of a transmission-blocking (TB)-Pfs48/45 peptide vaccine up to the phase of clinical testing
  • the identification and characterisation of novel parasite-and/or mosquito-derived targets for TB-immunity
  • the improvement of the bio-assay for the measurement of TB-immunity; identification of correlates of protection.
  • the development of a model for malaria transmission in non-human primates as a tool for functional analysis of vaccine candidates and a pre-screen for vaccine trials in humans.
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