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StopLATENT-TB


"LATENT TUBERCULOSIS: New tools for the detection and clearance of dormant Mycobacterium tuberculosis."
 
 
Framework programme:
 7
Project number:
200999
EC contribution:
€ 2,700,000
Duration:
36 months
Funding scheme :
Focused Research Project
Starting date:
01/02/2008
Website:
http://www.latentuberculosis.com
 
 

Keywords: Latent Tuberculosis; Dormancy models; Treatment of latent Tuberculosis.

Background

It is estimated that one-third of the human population is latently infected with Mycobacterium tuberculosis, constituting a major reservoir of that mycobacterium. The clinical definition of latency is clear, but the bacterial biology underlying this clinical situation remains poorly understood.

While dormant, the tubercle bacilli are considered to be in a non-replicating (NR) stage. In such a condition, bacilli are not only difficult to detect but also refractory to the standard treatments, avoiding their clearance from the infected tissues.

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