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Combined Highly Active Anti-retroviral Microbicides
Framework programme:
Project number:
EC contribution:
€ 12,000,000
60 months
Funding scheme :
Large scale collaborative project (IP)
Starting date:
Web site:

Keywords: HIV, microbicide, AIDS-prevention, anti-retroviral drug, NNRTI, integrase inhibitors, fusion inhibitors, formulation, intra-vaginal ring, clinical trial, biomarkers, proteomics, HIV in vitro testing, CCR5 inhibitors, RANTES analogues


According to the Joint United Nations Programme on HIV/AIDS (UNAIDS), 90% of cases of HIV are transmitted through sexual contact. Fidelity is no guarantee of protection; many women catch HIV from their husbands or long-term partners. Condoms are extremely effective at preventing HIV transmission, but many women are simply not empowered to force their partners to use them.

Microbicides represent a potential tool which could stop HIV transmission through sexual contact. As yet, there is no effective microbicide on the market. Nevertheless, the potential impact of a good microbicide is immense. Studies carried out by the London School of Hygiene and Tropical Medicine suggest that even a microbicide that is only 60% effective could still prevent 2.5 million cases of HIV over 3 years if just 20% of people in contact with local services in developing countries used it half the time.

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