Keywords: malaria, Plasmodium falciparum, drug development, protein synthesis, drug screening, apicoplast, tRNA, aminoacyl-tRNA synthetases, elongation factors
The protein synthesis machinery represents one of the most useful targets for the development of new anti-infectives. Several families of broadly used antibiotics (tetracyclines, macrolides, and novel glycopeptides like vancomycin, among others) exert their function by blocking the protein synthesis machinery. Doxycycline, a tetracycline antibiotic, remains a useful tool for the prevention of paludism among travellers, despite its numerous secondary effects. But very little is known about the specifics of the protein synthesis machinery in Plasmodium.
Lack of information about this central metabolic pathway in Plasmodium clearly blocks the possibility of transferring the knowledge in protein synthesis to the development of new antimalarial drugs directed against the translational machinery of the parasite. Thus, the study of components of the genetic code in Plasmodium has the potential for providing new and important information on the biology of the parasite and, more importantly, open new leads for the development of novel antimalarials.
Prof. Lluis Ribas de Poulana
|Official Address||Other Information|
|1||Dr Amit Sharma||International Centre for Genetic Engineering and
|2||Dr Magali Frugier||Centre National de la Recherche Scientifique
IBMC René Descartes
|3||Prof. Manuel Antonio da Silva Santos||Universidade de Aveiro
University of Aveiro
|4||Dr Miriam Royo Exposito||Fundacio Privada Parc Cientific de Barcelona
|5||Dr Stuart Ralph||University of Melbourne
|6||Dr Elisabetta Pizzi||Istituto Superiore di Sanita
|7||Dr Saman Habib||Council of Scientific and Industrial Research