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Strategies TO Prevent Pregnancy-Associated Malaria
Framework programme:
Contract/Grant agreement number:
EC contribution:
2.900.000 €
36 months
Funding scheme:
Focused Research Project
Starting date:

Keywords: Malaria, Plasmodium falciparum, pregnancy, var2csa, immune response


Pregnancy-associated malaria (PAM) is a major public health priority for women and children (two issues of strategic importance in the Seventh Framework Programme or FP7) in developing countries. Plasmodium falciparum is the only lethal form of malaria, responsible for 95% of attacks in sub-Saharan Africa where 90% of world mortality occurs. Moreover, the impact of PAM and the potential of its prevention particularly in primigravidae is obvious. The recent introduction of intermittent preventive treatment during pregnancy in endemic areas has improved PAM prevention but it clearly depends on the level of drug resistance. Because of the very complex interactions network, control of a particular stage of host-parasite relationships offers a more pragmatic aim than infection control for a vaccine. Moreover, this innovation is independent of drug pressure, and makes it possible to develop a long-term tool to prevent PAM.

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