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STOPPAM


Strategies TO Prevent Pregnancy-Associated Malaria
 
 
Framework programme:
 7
Contract/Grant agreement number:
200889
EC contribution:
2.900.000 €
Duration:
36 months
Funding scheme:
Focused Research Project
Starting date:
02/01/2008
Web-site:
http://www.stoppam.org/

Keywords: Malaria, Plasmodium falciparum, pregnancy, var2csa, immune response

Background

Pregnancy-associated malaria (PAM) is a major public health priority for women and children (two issues of strategic importance in the Seventh Framework Programme or FP7) in developing countries. Plasmodium falciparum is the only lethal form of malaria, responsible for 95% of attacks in sub-Saharan Africa where 90% of world mortality occurs. Moreover, the impact of PAM and the potential of its prevention particularly in primigravidae is obvious. The recent introduction of intermittent preventive treatment during pregnancy in endemic areas has improved PAM prevention but it clearly depends on the level of drug resistance. Because of the very complex interactions network, control of a particular stage of host-parasite relationships offers a more pragmatic aim than infection control for a vaccine. Moreover, this innovation is independent of drug pressure, and makes it possible to develop a long-term tool to prevent PAM.

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