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SERO-TB


Tuberculosis

Development of a Specific Serological Kit for the Diagnosis of TB
Framework programme:
6
Call:
3
Project number:
LSHP-CT-2006-037796
EC contribution:
€ 827,313
Duration:
36 Months
Type:
STREP
Starting date:
December 2006

Keywords: Tuberculosis; serodiagnosis; antibodies; diagnostics, immunochromatographic test

Summary:

There is a great need for simple and robust diagnostic methods for the diagnosis of tuberculosis (TB). From the basis of a through-screening process ten M. tuberculosis antigens have been identified, exhibiting potential as serodiagnostic TB antigens. Two to three of these antigens will be selected with the aim of achieving the highest sensitivity and specificity in a setting with a high number of latent TB infections and HIV co-infection. The selection will be based on evaluating patients with TB, latently infected individuals and symptomatic non-TB patients.

The selected antigens will be incorporated into an immunochromatographic test (ICT) which will be optimised for the detection of M. tuberculosis-specific antibodies. Prototypes of the test kit will be produced and inhouse proof of performance data generated. Finally, the performance of this test kit will be evaluated in a real life scenario in two independent hospital settings in Turkey and Ethiopia.

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