Navigation path

Allomicrovac


HIV/AIDS

A combined microbicidal-immunizing strategy against SIV and HIV infection
Framework programme:
6
Call:
4
Project number:
LSHP-CT-2006-036928
EC contribution:
€ 1,100,000
Duration:
24 Months
Type:
STREP
Starting date:
1st January 2007

Keywords: HIV microbicide, preventive vaccine, therapeutic vaccine

Summary:

The objective of the proposed project is to establish proof of concept that a trimolecular construct, consisting of MHC antigens combined with microbial HSP70 and extracellular CCR5 peptides can be utilized in microbicidal, preventive and therapeutic immunization. This strategy utilizes a novel microbicidal-immunogenic agent to protect against mucosal SHIV infection in female macaques. The construct blocks HIV-1 or SIV binding CCR5- coreceptors and elicits both extracellular and intracellular anti-HIV-1 or -SIV factors. However, as the trimolecular agent is immunogenic, repeated applications will elicit mucosal, regional and systemic immunity. Furthermore, it elicits innate antiviral responses and targets different stages in the infectious process. The novel strategy of combining a short term microbicide with a longterm preventive vaccine may deal with the serious difficulty of compliance, demanded by repeated application of microbicides before each intercourse.

[+] Read More