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CASCADE

HIV/AIDS

Concerted Action on SeroConversion to AIDS and Death in Europe
Framework programme:
6
Call:
3
Project number:
LSHP-CT-2006-018949
EC contribution:
€ 1 700 000
Duration:
48 months
Type:
CA
Starting date:
1st March 2006

Keywords: HIV; seroconverters; observational; survival; AIDS; antiretroviral; incidence

Summary:

CASCADE was established in 1997 as a collaboration between the investigators of 22 cohorts of people with well-estimated dates of HIV seroconversion (seroconverters). It is currently a network of epidemiologists, statisticians, virologists and clinicians from leading HIV institutions in 13 European countries, Australia and Canada. Seroconverters are enrolled into the individual cohorts locally and nationally, and are typically followed up for the whole of life. CASCADE’s main aim is to monitor newly infected individuals and those already enrolled in studies, covering the entire duration of HIV infection. The main premise is that through pooling data issues will be addressed, which cannot be reliably addressed from single studies alone.

Background:

Follow-up data from seroconverters are valuable in being able to relate events to the same timeframe since an individual first became infected with HIV. Seroconverters thus provide a unique opportunity to study HIV throughout its whole infection period and also enable examination of the characteristics of recently acquired HIV infection in the population and changes over time.

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