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Tuberculosis China


Tuberculosis

The Diversity of Mycobacterium Tuberculosis Strains in China: Tracing the Origins of the Worldwide Dispersion of the Multidrug-Resistant Beijing Genotype
Framework programme:
6
Call:
2
Project number:
LSHP-CT-2005-012166
EC contribution:
€ 150,000
Duration:
24 months
Type:
SSA
Starting date:
1 June 2005

Keywords: China; Mycobacterium tuberculosis; diversity; molecular epidemiology; VNTR typing; Beijing genotype; multidrug-resistance

Summary:

This project proposes to organise the analysis of a large collection of strains (3 000) from the 31 provinces of China and the data will be compared to the characteristics of strains collected in other countries. This will produce knowledge on the diversity of Chinese TB strains and show whether the dispersion of the Beijing type is of clonal origin.

Background:

The Beijing genotype is prevalent in China. Strains of a similar genotype are found worldwide, particularly in Eastern Europe and in the countries of the former Soviet Union, and are often associated with multidrug-resistance. The very rapid and efficient dispersion of the Beijing strains suggest that they may have developed selective advantages.

Aim:

The present SSA aims at preparing the project in collaboration with Chinese scientists, transfer the technical knowledge, follow the progress of the experiments, collect the data in a shared-database and produce population analyses.

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