Keywords: China; Mycobacterium tuberculosis; diversity; molecular epidemiology; VNTR typing; Beijing genotype; multidrug-resistance
This project proposes to organise the analysis of a large collection of strains (3 000) from the 31 provinces of China and the data will be compared to the characteristics of strains collected in other countries. This will produce knowledge on the diversity of Chinese TB strains and show whether the dispersion of the Beijing type is of clonal origin.
The Beijing genotype is prevalent in China. Strains of a similar genotype are found worldwide, particularly in Eastern Europe and in the countries of the former Soviet Union, and are often associated with multidrug-resistance. The very rapid and efficient dispersion of the Beijing strains suggest that they may have developed selective advantages.
The present SSA aims at preparing the project in collaboration with Chinese scientists, transfer the technical knowledge, follow the progress of the experiments, collect the data in a shared-database and produce population analyses.
The different partners will first define the characteristics of the population to be included in the protocol, and choose the appropriate methods for genotyping and multidrug-resistance (MDR) assessment. Data on the BCG status, age and gender of the patients as well as other relevant clinical information will be collected. Technical knowledge will be transmitted when necessary to Chinese laboratories through exchanges.
In China, a large proportion of the population is infected by Mycobacterium tuberculosis with 500 000 new cases every year. The attenuated Mycobacterium bovis Bacillus Calmette Guerin (BCG) is the only available vaccine against TB. However, this vaccine does not provide consistent protection against TB. Knowledge of the diversity of the M tuberculosis strains is of major importance to identify M. tuberculosis antigens and epitopes for new protective vaccines and specific diagnostic reagents.
Institut de Génétique et Microbiologie, Bât 400
Université Paris Sud-XI
91405 Orsay Cedex
Tel: +33 1 69 15 30 01
Fax: +33 1 69 15 66 78
|Official Address||Other Information|
|2||Dick van Soolingen ||National Mycobacteria |
National Institute of Public Health and the Environment
PO BOX 1
NL-3720 BA Bilthoven
|Tel: +31 30 2742363 |
Fax: +31 30 2744418