Development of rapid field diagnostics for identification, control and management of haemorrhagic fever outbreaks
This project proposes to develop and validate diagnostic tools for early viral haemorrhagic fever outbreak detection and control. A frontline line-assay carrying antigens of all African haemorrhagic fever viruses is to be developed and validated for widespread use in bush hospitals.
This assay is easy to use and the results are easy to interpret. It is also cheap to produce and has a long shelf life. This tool will help to improve outbreak detection in Africa. The project includes long-term field trials in bush hospitals. A mobile integrated F-RT-PCR for outbreak investigation teams is to be developed.
It will consist of a panel of F-RT-PCRs covering all haemorrhagic fever viruses, a robust simple nucleic acid extraction protocol and ready to use lyophilised PCR mixes. This tool will help outbreak investigation teams to improve their ability to manage and control haemorrhagic fever outbreaks.
A consortium of 3 European laboratories and 4 African laboratories will provide the expertise for the development, validation and adaptation to filed use of both tools.
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