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Viral diseases

Towards successful dengue control

Project Number
: 517708
: 34 months
EC contribution
: € 2,500,000
: Specific Targeted Research Projects (STREP) and Coordination Actions (CA) for Developing countries (DEV)
: Viral diseases
Starting date
: 01/11/2005


Dengue, the most rapidly expanding viral disease in S-East Asia and Latin America, is a major neglected and uncontrolled disease. This project will provide new knowledge, tools and strategies in 3 key areas:

  1. Improved knowledge of the immunopathology of severe dengue contributing to the development of a safe and efficacious vaccine and eventually to improved treatment
  2. Improved case-management through a modified dengue case definition and treatment guidelines and eventually the identification of early warning signs for severe disease
  3. Improved protection from disease transmission by means of novel vector control tools which are applied through a new cost-effective strategy

The specific objectives of the project are:

  1. To create new knowledge about virus genetic factors of virulence, immune response and pathophysiological mechanisms across regions (SE Asia and LA) relevant to clinical management of severe disease and vaccine development
  2. a/ To obtain a clear distinction between dengue and severe dengue by developing an evidence-based case classification procedure
    b/ To develop case management guidelines that will use the revised case classification and subsequently reduce morbidity and mortality
  3. To test novel vector control tools (long-lasting insectic ide treated curtains and/or water container overs and/or slow-release insect growth regulators) which reduce vector densities below epidemic threshold levels
  4. To assess key strategies which deliver new vector control tools regarding their cost-effectivene ss,acceptability and sustainability in contrasting environments
  5. To demonstrate and document the timely translation of research findings into policy and practice (clinical as well as control)

The 5 work packages related to these objectives are designed by a multidisciplinary team of scientists from disease endemic countries in SE Asia, LA and from Europe.
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