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Protozoan diseases Projects

Syndromic approach to neglected infectious diseases (NID) at primary health care level: an international collaboration on integrated diagnosis-treatment platforms

EC contribution
: € 5,000,000
: 60 months
Starting date
: 01/11/2010
Funding scheme
: Collaborative Project (SICA)
Contract/Grant agreement number
: 260260
Project web-site

Keywords: neglected infectious diseases, diagnosis, rapid diagnostic tests, algorithms, cost-effectiveness


Treatment options for neglected infectious diseases (NID) (box 1) are generally few and the problem is exacerbated by a critical lack of appropriate diagnostic tools to guide treatment. A major challenge in the clinical management of NID is the weakness of health systems of disease-endemic countries. People affected by NID mostly present to primary health care, which are generally under-staffed and ill-equipped, resulting in a low quality of care. Misdiagnosis is frequent, as the clinical presentation of many NID is non-specific and may be confounded with that of other common conditions. NIDIAG will develop and validate upgraded, evidence-based, widely applicable and cost-effective algorithms for diagnosis and treatment that incorporate key clinical symptoms and signs, as well as existing or newly developed rapid diagnostic tests (RDT) for each of three clinical syndromes that are major clinical presentations of many NID, namely the persistent fever, intestinal and neurological syndromes.

Neglected infectious diseases

They include a range of acute or chronic lethal or disabling infections such as Buruli ulcer, Chagas disease, cysticercosis, dengue, dracunculiasis, endemic treponematoses, enteric fever, human African trypanosomiasis (sleeping sickness), leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthiasis, trachoma, food-borne trematodiasis.


Globally an estimated 1.2 billion people are affected by one or more NID that thrive among impoverished populations of developing countries, in remote rural areas, urban slums and conflict zones.
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