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Helminth Diseases

Helminth diseases are caused by parasitic worms that can be classified as either nematodes, cestodes or trematodes. Lymphatic filariasis (elephantiasis), which is one of the most devastating NID's, is caused by nematode worms, and nematodes include  also the soil-transmitted (or gastrointestinal) helminths, causing ascariasis, trichuriasis and hookworm infection. The Cestodes include tapeworms of the Taenia and Echinococcus families, whereas Schistosomiasis is caused by worms of the trematode family.


PRIORITY DISEASES Infectious Agent
KEY RESEARCH GAPS
Discovery and Development Disease Control and Implementation Research
Lympathic filariasis (Elephantiasis) Wuchereria bancrofti, Brugia malayi, and Brugia timori nematode worms
Drugs (adult worm), drug resi stance, animal models, vaccine Robust, easy and affordable diagnostics,    improved vector control
Schistosomiasis (Bilharzia) Schistosoma flatworms
Vaccines, drug resistance Diagnostics, improved vector control
Ascariasis Ascaris lumbricoides
Vaccines, drug efficacy Easy and affordable diagnostics, improved vector control
Trichuriasis Trichuris trichiura (whipworm).
Vaccines Easy and affordable diagnostics, improved vector control
Hookworm Ancylostoma duodenale and Necator americanus
Drugs and drug targets; drug resistance, vaccines Easy and affordable diagnostics, improved vector control