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RNAFLU


Biology, Target Search and Drug Discovery

Effect of Natural Viral RNA Sequence Variation on Influenza Virus RNA Function

EC contribution
: € 1.262.959
Duration
: 24 months
Starting date
: 01/02/2008
Funding scheme
: Collaborative project - Small- or medium-scale focused research project
Keywords
: influenza, Spanish flu, bird flu, pathogenic, RNA, secondary structure, microRNA, splicing, translation, nmr
Contract/Grant agreement number
: 201607
Project web-site
: -

Summary:

Influenza A virus has an amazing ability to rapidly change its properties. We believe that pathogenic properties of an influenza virus could be determined also by differences in influenza virus RNA sequence that do not affect the protein sequence of the virus genome. In other words, sequences that affect structure and/or function of the viral RNA, could themselves contribute to the pathogenic properties of the influenza A virus, as well as its ability to adopt to a new host. All RNAs in a cell are associated with proteins and RNAs are dependent on these interactions to function efficiently. Interactions of RNA with proteins depend on the RNA sequence and secondary structure. The exact RNA sequence is therefore of paramount importance since it affects secondary structure and function and utilisation efficiencies of the viral RNAs. RNA sequence has a direct effect on mRNA splicing, mRNA stability and translation. The exact sequence of the influenza virus RNA should therefore affect the replication efficiency of each virus strain. It is reasonable to speculate that RNA sequence variation itself can affect virus pathogenic properties.

Problem:

Can pathogenic properties of various influenza viruses be determined by differences in influenza virus RNA genome that do not affect viral protein sequences ?

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