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PORTFASTFLU


Diagnostics and Surveillance

Portable automated test for fast detection and surveillance of influenza

EC contribution
: € 2 965 874
Duration
: 36 months
Starting date
: 01/01/2008
Funding scheme
: Collaborative project - Small- or medium-scale focused research project targeted to SMEs
Keywords
: Infectious diseases, viruses, diagnosis, diagnostic tests, emerging technologies, biochips, microarrays, lab on chip
Contract/Grant agreement number
: 201914
Web-site
: www.portfastflu.com

Summary:

The PORTFASTFLU's objective is to develop and validate a rapid diagnostic test for influenza that will be used as point-of-care systems in developed and developing countries. Experts and international bodies agree that the rapid detection of influenza is vital in combating this major threat to human health. Nucleic acid analysis is the most appropriate assay scheme for both early detection and late surveillance of influenza, and is routinely used by WHO and OIE virology reference laboratories. PORTFASTFLU's consortium aims at developing and validating a Point of Care (POC) Funding scheme which will integrate sample preparation, nucleic acid amplification, microarray hybridization and fluorescent readout in a single system. Reaching this challenging objective is possible through the combined expertise of the partners and comprises access to several selected enabling technologies: microfluidics, on-chip sample preparation, advanced microarray techniques and reading systems with ultimate sensitivity and selectivity, access to reference and field virus samples. This Bio-Micro knowledge converges in one single instrument, allowing rapid detection (less than an hour) and simultaneous identification of influenza A and B viruses (typing and sub-typing) at widespread POC with only basic skills. Furthermore, the project also aims at realizing this goal in a format that requires little supervision and is integrated in a portable compact monolithic system for deployment in the field.

The consortium of 8 partners from 5 member states brings together the various expertises needed to reach these objectives.

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