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SARS-DTV


SARS

Complementar y research action to suport SARS-related diagnostic tests, therapeutic interventions and vaccine development

EC contribution
: € 2 386 860
Duration
: 36 months
Starting date
: 01/10/2004
Instrument
: STREP
Keywords
: SARS, coronaviruses, molecular biology, structural genomics, antiviral drugs, vaccines, human monoclonal antibodies, T-cell epitopes, reverse genetics, replicon cell lines, rapid diagnostics
Project Number
: SP22-CT-2004-511064
Web-site
: http://www.sars-dtv.nl/

Summary:

Severe Acute Respiratory Syndrome (SARS) is a life-threatening form of pneumonia caused by an emerging Coronavirus (SARS-CoV) that likely circulates in bats. The prevention and/ or containment of future outbreaks of this virus, or any of its relatives, will depend on our understanding of their biology, pathogenesis and evolution. To aid in designing an overall strategy, the SARS-DTV project focused its attention on the development of reliable diagnostic tools, specific antiviral compounds, and a SARS-CoV vaccine.

Problem:

Due to their high mutation frequency, RNA viruses are the most common source of unanticipated virus outbreaks, which are caused either by novel variants of known viruses of by the introduction into the human population of previously unknown viruses, often transmitted from an animal source.

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