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DENFRAME


Denge and other haemorhagic fevers

Innovative diagnostic tools and therapeutic aproaches for dengue disease

EC contribution
: € 2 550 000
Duration
: 36 months
Starting date
: 01/11/2005
Instrument
: STREP
Keywords
: dengue, innate immunity, diagnostic tools
Project Number
: INCO-CT-2005-517711
Web-site
: http://www.denframe.org

Summary:

Dengue disease is a mosquito-borne viral disease that is one of the foremost public health issues in developing countries. Up to 100 million cases are reported each year. Over 500 000 cases of a life-threatening form of the illness, known as dengue hemorrhagic fever (DHF), occur each year, with about 25 000 fatalities (mainly children under 15). To date, there is no specific prevention or treatment.

The main aim of the DENFRAME project is to improve the management of dengue disease in the human populations of Latin America and Asia. The goals of the project are to develop and implement new diagnostic tools, to devise a comprehensive approach of innate immune response to the infection and to develop lead compounds inhibitors of Dengue virus (DV) replication. Additional goals include the collection of well-characterised data, identification of prognosis factors involved in disease severity, and standardisation of current diagnostic assays.

To reach these goals, two complementary Work Programmes (WPs) are being developed:

  1. WP1 concentrates on the standardisation and validation of the current diagnostic assays, and the development of new diagnostic tools.
  2. WP2 aims at developing an integrated approach to understand the DV-host interactions focusing on key components of innate immunity, and identifying potential therapeutic agents.
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