Towards sucessful dengue prevention and control
The DENCO (dengue control) research programme covers a wide spectrum of applied research including clinical research (i.e. case classification and management, evaluation of new diagnostics), vector research (i.e. development of user friendly and effective vector control tools), strategy research (i.e. identification of cost-effective partnership approaches in the control of the disease and its vectors), and pathogenesis research (i.e. to improve our understanding of the natural history of the disease, necessary for vaccine and drug development and evaluation).
Partners of the DENCO study include institutions from Europe, from Disease Endemic Countries (DECs) as well as TDR - the research arm of the World Health Organization (WHO) for Tropical Diseases.
First results will be available in the course of the year 2008. A large research platform has been created to foster collaborative research on this important disease. Dengue also has a high probability of being one of the major diseases benefiting from global climate change and its consequences.
Basic research, implementation research and the interface of research and policy are components of the DENCO study (WP=Work Package; P1-9 = partners 1-9)
An alarming global spread of dengue disease has been ongoing in the last decades with a substantial social and economic burden placed on both individuals and their societies. This mosquito-borne disease is a major threat to public health throughout South-East Asia and Latin America.
The comprehensive research agenda is aimed at advancing our understanding of dengue pathogenesis and providing better tools for dengue control.
The process of updating the global dengue guidelines was initiated by the WHO in late 2006 and is continued through 2008. The findings of the clinical part of the DENCO study can contribute to the re-shaping of dengue prevention and control in the near future. The empirically based outcome of severe disease, which is being validated in the clinical studies, will also have implications on the design of pathogenesis studies and vaccine studies.
The findings of the studies on vector control efficacy and acceptability will be important in order to inform policy in DECs. Pathogenesis studies will lead to an increase in knowledge about viral factors correlated with severe disease over a wide geographic range (seven countries in two continents).