|The 3rd Call FP7 published - Deadline: 03 December 2008 at 17:00:00 (Brussels local time)|
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TRANSLATIONAL RESEARCH IN MAJOR INFECTIOUS DISEASES: TO CONFRONT MAJOR THREATS TO PUBLIC HEALTH
Potentially new and re-emerging epidemics
The focus will be on confronting emerging pathogens with pandemic potential including zoonoses (e.g. SARS and highly pathogenic influenza). Call topics aim to cover the full 'value chain of health research: from innovative basic research to early stage clinical trials of new prevention, diagnostic and therapeutic measures all the way to implementation research supporting effective public health responses. This includes the vital need for new rapid and reliable diagnostic tools, the search for more efficient and broadly protecting vaccines, and the study of alternative treatment strategies and nonpharmaceutical approaches in patient management.
Expected impact: The results of research in this area will integrate European scientific
excellence and make Europe better prepared for emerging epidemics: Influenza
containment and mitigation strategies are a vital tool to limit spread of the disease, and
recommendations regarding the use (and possible stockpiling) of personal protection
equipment, especially in the case of a pandemic are a major challenge to national public
health authorities, since the evidence base in this case is insufficient.
HEALTH-2009-2.3.3-1: Efficacy and effectiveness of personal protection equipment and other measures against influenza transmission. FP7- HEALTH-2009-single-stage.
The project should determine the efficacy and effectiveness of contact, droplet, and airborne precautions in reducing the risk for influenza infection with particular regard to the role of surgical- and respiratortype masks. The objective is to demonstrate through appropriately designed experimental human and/or animal studies the relative contribution of different modes of influenza transmission (such as large droplets and droplet nuclei) as well as through a controlled human in vivo study the protection afforded by the use of surgical- vs. respirator-type masks (prevention of influenza in the individual wearing the mask) as well as other measures (e.g. isolation, distancing, hygiene, air sterilisation). The study questions should be formulated such that results will directly inform recommendations for use of particular mask types in specified settings for the prevention of seasonal and pandemic influenza transmission. The study setting for the in vivo study will necessarily be during the season during which influenza and other respiratory diseases are most prevalent, in healthcare or other sites where there is greatest risk for transmission (and therefore the best place to detect differences in effectiveness and efficacy), in multiple sites and over multiple influenza seasons. The study may also consider potential barriers to use of masks and other measures, such as user acceptability.
Funding scheme: Collaborative Project (Small or medium-scale focused research project).