Navigation path


Biofilm Alliance
EC contribution
: € 2.999.710
: 60 months
Starting date
: 01/10/2011
Funding scheme
: collaborative project
: biomaterial-associated infection, orthopedic infection, catheter, biofilm, tissue colonization, antimicrobial peptide, controlled drug release, antibiotic resistance.
Contract/Grant agreement number
: 278890
Project web-site


The BALI consortium performs multidisciplinary research to design Synthetic Antimicrobial Antibiofilm Peptides (SAAP) and a release system which can be applied to the surface of biomaterials as a coating. We aim to develop novel SAAPs with optimized in vitro antimicrobial, anti-inflammatory and biofilm-dispersing activity (WP2) and to investigate their mode of action (WP3). An innovative delivery formulation (PolyPid platform) will be used to allow prolonged and pre-determined release rates of the most promising SAAPs (WP4).

This platform ensures local delivery of effective concentrations of the peptide over a sufficient duration and can be developed into coatings for different types of implants. To obtain in vivo proof of concept, the efficacy to prevent and treat biomaterial-associated infections of PolyPid/SAAP-coated polymer and titanium implants will be tested in various clinically relevant in vivo model systems (WP5 and WP6). The most promising SAAP will be produced under GMP conditions and the PolyPid/SAAP coating will be evaluated in a first human Phase I clinical trial to study the safety and efficacy of coated intramedullary nails (WP7). Results will be actively disseminated to specialized and general audiences (WP8).

[+] Read More