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C4L

Chips for Life
EC contribution
: € 2.876.300
Duration
: 36 months
Starting date
: 01/01/2012
Funding scheme
: Collaborative-project
Keywords
: Respiratory infections, diagnostic, multiplex, antibiotics, microfluidics, resistance, virulence factors, virus, bacteria.
Contract/Grant agreement number
: 278720
Project web-site
: http://www.chips4life.eu

Summary:

Respiratory tract infections (RTIs) are a huge burden in terms of mortality and morbidity worldwide. To improve the management of bacterial infections of the respiratory tract, an appropriate antimicrobial therapy should be initiated as soon as possible. This has also been shown to be a key element for reducing morbidity and mortality.

The aim of our project is to develop a panel of dedicated rapid diagnostic tests to allow the medical staff to link antibiotic prescription to evidence-based diagnosis. In our 3 year project, combining Multiplex Ligation-dependent Probe Amplification (MLPA) and microfluidic technologies will allow to differentiate between infections of viral or bacterial origin. In case of a bacterial infection, a second step will allow to identify the causative bacteria and determine virulence factors and resistance mechanisms. This new tool will be developed for efficient use in clinical settings in order to allow for a better management of antibiotic resistance.

Several direct impacts will be studied either on public health (decrease of antibiotic pressure), efficiency of treatment for patients (decrease of infectivity and speed in accurate treatments), for diagnostic laboratories (improve in turn-around time), for SMEs (better competitiveness) and more generally on technological innovations.



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