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A stealth attack tool for preventing clinical drug resistance through a unique self-regenerating surface
EC contribution
: € 2.990.698
: 48 months
Starting date
: 01/01/2012
Funding scheme
: SME-targeted Collaborative Project
: biofilm prevention, catheters, interpenetrating polymer networks, antimicrobial peptides, release, clinical drug resistance, silicone, hydrogels.
Contract/Grant agreement number
: 278998
Project web-site


Outbreaks of clinical infections affect many thousands of patients in Europe yearly. The present effective treatment for infections is large doses of systemically applied drugs. There is a high risk of recurring infections and biofilm formation for patients dependent on long term in-dwelling catheters and the extended dependency on antibiotics resulting in clinical drug resistance. We present a new tool for minimizing drug resistance by upgrading existing and future medical devices through a unique self-regenerating surface that prevents biofilm formation using a stealth attack mechanism. This will be achieved by an interpenetrating polymer network (IPN) that allows for long term release of a range of antimicrobial strategies. The IPNs contain hydrogels where the antimicrobial is stored until the release starts at the insertion of the device with an expected long-term effect. Local and site-specific treatment with long term effect instead of systemic treatment implies improved patient management and citizen well-fare.

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