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Resistance in Gram-negative organisms: Studying intervention strategies
EC contribution
: € 11.999.999
: 60 months
Starting date
: 01/10/2011
Funding scheme
: Collaborative project
: antibiotic resistance, Gram-negative bacteria, infection control
Contract/Grant agreement number
: 282512
Project web-site
: -


The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical intervention studies, all supported by highly innovative microbiology and mathematical modelling, to determine - in the most relevant patient populations - the efficacy and effectiveness of cutting-edge interventions to reduce acquisition, carriage, infection and spread of Multi-Drug Resistant Gram-negative Bacteria (MDR-GNB).

All clinical work-packages (WPs) will progress science beyond the state-of-the-art in generating new and translational clinically relevant knowledge, through hypothesis-driven studies with a focus on patient-centred outcomes that matter to the people of Europe and beyond. Separate horizontal WPs will deliver transformational project-management, data-management and dissemination. The studies and analyses proposed in R-GNOSIS will generate a step-change in identifying evidence-based preventive measures and clinical guidance for primary care and hospital-based physicians, as well as health-care authorities, to combat the spread and impact of the unprecedented rise of infections caused by MDR-GNB in Europe.

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