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TB Treatment Marker


Establishing a TB treatment efficacy marker
EC contribution
: € 375.104
Duration
: 24 months + 12 months extension
Starting date
: 01/01/2005
Funding scheme
: Specific Support Action
Keywords
: tuberculosis; treatment efficacy marker; suPAR; capacity building; poverty related diseases; prognostics; clinical study
Contract/Grant agreement number
: LSSP-CT-2005-012173
Project web-site
: http://www.youtube.com/watch?v=deH1gAVUyZQ

Background:

The focus of the TB Treatment Marker project was on investigating the possibility of creating a novel approach to monitor tuberculosis (TB) treatment efficacy, which would lead to a more rational use of drugs, and reduce the incidences of resistance to TB medication.

Since the war in the 1990s in Guinea Bissau, laboratory facilities for diagnosing TB have been inadequate. As part of the project, the consortium built a functional TB laboratory.

Of some 2 000 screened TB suspects, 400 diagnosed with active TB were included in the study by December 2006 and an 8-month treatment follow-up was carried out.

Problem:

No method to successfully monitor the efficacy of TB treatment currently exists. Upon diagnosis, patients are treated for TB with a course of medication lasting approximately six to nine months. Prior to the end of the treatment regime, there exists very little indication of the efficacy of the particular treatment.
If the primary treatment fails, a stringent and time-consuming analysis is made to select appropriate and effective antibiotics as a second-line treatment.

Mortality is high in both TB suspects and in TB patients during treatment, and simple and inexpensive methods for identifying individuals at risk are warranted.

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