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Novel opportunities to develop vaccines to control antibiotic resistant bacteria: from the trials back to the laboratory
EC contribution
: € 121.200
: 12 months
Starting date
: 01/09/2006
Funding scheme
: Specific Support Action
: -
Contract/Grant agreement number
: LSHM-CT-2006-037163
Project web-site


Antibiotic resistant bacteria are rapidly spreading worldwide, making it increasingly difficult to treat infections in large communities as well as creating a major public health problem. Vaccination is proposed as one of the best tools to stop the spread and development of antimicrobial resistant micro-organisms. However, the analysis of the effects of using conjugated vaccines against Streptococcus pneumonia, Haemophilus influenzae b and Neisseria meningitidis has shown some paradoxes and some interesting aspects that led to a re-thinking of how immunity to polysaccharide is elicited following vaccination and how memory is acquired.

The workshop proposed by REBAVAC - involving some of the most important experts in vaccination, immunology and bacterial resistance, both from industry and academia, - has surely represented a very important opportunity in Europe to discuss the implication of the results of ongoing research on the use and development of vaccines to fight antibiotic resistant bacteria.
In addition it has been a major occasion to analyse and discuss the current status of protein-based vaccines and the importance of innovative vaccination strategies to give indications to the European research for the development of more efficacious, universal and affordable vaccines to defeat antibiotic resistant bacteria.

Moreover the training session was an opportunity for young scientists to present their research, whereas a round table with industries representatives, policy makers and scientists represented an occasion to discuss the efficacy of vaccination and the economical and political aspects related with the development, use and distribution of vaccines to encapsulated bacteria. A Position paper on "Future trends in vaccine development to defeat antibiotic resistant bacteria" is in preparation and it will be made available to the public.

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