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MOSAR


Mastering hospital antimicrobial resistance and its spread into the community
EC contribution
: € 10.000.000
Duration
: 60 months
Starting date
: 01/02/2007
Funding scheme
: Integrated Project
Keywords
: antimicrobial resistance, cross-transmission, diagnostic tests, infection control, prevention, typing, statistical models
Contract/Grant agreement number
: LSHM-CT-2007-037941
Project web-site
: http://www.mosar-sic.org

Background:

Infections caused by antimicrobial-resistant bacteria (AMRB) account for an increasing proportion of healthcare-associated infections in European hospitals, particularly in high-risk units like intensive care units (ICUs)and surgery. Patients discharged to rehabilitation care units often remain long-term carriers of AMRB, contributing to their dissemination into other care areas and within the community. Increased prevalence of resistance to antibiotics of major hospital pathogens is associated with adverse outcomes of patients affected, and includes delayed appropriate therapy or even failure of therapy, prolonged length of hospital stay, and increased mortality.

While the optimal strategies for control of AMRB remain debated, understanding the dynamics of resistance and the relative contribution of the most important determinants of dissemination of AMRB (cross-transmission via contacts and antimicrobial selective pressure), is needed to better define these strategies. The integration in these approaches of rapid molecular diagnostic testing for AMRB carriage may improve the timeliness and efficacy of control measures.

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