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Genomics to combat resistance against antibiotics in community-acquired LRTI in Europe
EC contribution
: € 11.500.000
: 60 months
Starting date
: 01/03/2006
Funding scheme
: Network of Excellence
: antimicrobial resistance, community-acquired lower respiratory tract infections, genomics, health education
Contract/Grant agreement number
: LSHM-CT-2005-518226
Project web-site


GRACE is a NoE focusing on the complex and controversial field of community-acquired lower respiratory tract infections (CA-LRTI), which is one of the leading reasons for seeking medical care. The promiscuous use of antibiotics to treat LRTI accounts for a major part of the community burden of antibiotic use and contributes dramatically to the rising prevalence of resistance among major human pathogens. The overall objective of GRACE is to combat antimicrobial resistance through integrating centres of research excellence and exploiting genomics in the investigation of CA-LRTI. Microbial and human genomics will be integrated with health sciences research consisting of clinical observational and intervention studies, health economics and health education to change practice in managing CA-LRTI. In the jointly executed research programme, 28 academic groups, spread across 14 EU Member States and 4 SMEs will participate. GRACE will organise professional education, including web-based teaching and practical courses through two leading European scientific societies (European Society of Clinical Microbiology and Infectious Diseases and European Respiratory Society).

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