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Genetics of sepsis in Europe
EC contribution
: € 2.000.000
: 48 months
Starting date
: 01/01/2005
Funding scheme
: Specific Targeted Research Projectx
: intensive care medicine, sepsis, mortality, epidemiology, genetic testing, genetic predisposition
Contract/Grant agreement number
: LSHB-CT-2004-512155
Project web-site


GenOSept is a STREP which uses a multidisciplinary fundamental genomics approach (gene expression, structural genomics and population genetics) to examine genetic predisposition to sepsis.

Sepsis (a life-threatening infection) is a major public health problem throughout Europe. In the USA, in 1995, it cost $17 billion to treat 751 000 patients with severe sepsis, of whom 28.6% died. The Centre for Disease Control suggests that sepsis-attributable mortality rates are rising. We hypothesise that susceptibility to expensive new treatments and fatal outcomes from severe sepsis are, in part, genetically determined.

The GenOSept project will test this hypothesis. The partners aimed to standardise protocols for genotyping, facilitate application of new knowledge in functional and structural genomics, harmonise high-throughput genotyping and quality control between major European centres, and contribute to reducing sepsis-related mortality in European healthcare.

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