Navigation path

AMIS


Antimicrobials by immune stimulation
EC contribution
: € 2.100.000
Duration
: 36 months
Starting date
: 01/01/2005
Funding scheme
: Specific Targeted Research Project
Keywords
: immunology, infections, novel antimicrobial approach, immune stimulation, fusion compounds
Contract/Grant agreement number
: LSHM-CT-2004-512093
Project web-site
: -

Background:

AMIS aims to use the strength of our own innate immune system to design antimicrobial drugs for future generations. Antimicrobial proteins in our immune system are often combined with inflammatory signals in one single molecule. AMIS will take that same approach and reshuffle different parts of different molecules to make novel effector molecules that still have these combined functions but are optimally adapted for therapeutic intervention. Within our innate immune system many molecules have been identified over the last years that are involved in direct or indirect clearance of bacteria. The consortium will select the most promising and innovative compounds with this dual mode of action and:

  • Design proteins with anti-microbial activity in combination with an inflammatory trigger, targeting extra cellular bacteria;
  • Design proteins with inflammatory priming capacity (without extra anti-microbial activity); targeting intracellular bacteria;
  • Discover new modulators to dampen inflammation.
[+] Read More