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Assessment and critical evaluation of antibiotic resistance transferability in food chain
EC contribution
: € 2.462.000
: 36 months (+6 of extension)
Starting date
: 01/01/2004
Funding scheme
: Specific Targeted Research Project
: food chain, drug resistance, Lactobacillus, Bifidobacterium, methods
Contract/Grant agreement number
: 506214
Project web-site


The project Assessment and Critical Evaluation of Antibiotic Resistance Transferability in Food Chain (ACE-ART) is aimed to provide a critical evaluation of the impact on non pathogenic bacteria of antibiotic use in agriculture and in the prophylaxis and treatment of disease in humans. Workpackage 1 of this project has assembled, maintained and used a collection of about 1400 bacterial strains belonging to 20 species of Lactobacillus, Bifidobacterium, Lactococcus and Streptococcus thermophilus to develop standardised phenotypic procedures to detect strains showing a level of antibiotic resistance atypical for their species. These procedures have been validated by means of a ring test among WP1 members. Collaboration has been established with the Joint Action Team of ISO and FIL/IDF and the process to transform the procedures developed by ACEART into an ISO standard is now in progress. In the meantime, phenotypic results obtained in this year by WP1 have been used by the panel FEEDAP of EFSA for safety assessment of bacterial strains applying for approval as feed additives of plant protection agents. This achievement is of relevance, as this support to EU policy was among the objectives to be achieved by the project.

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