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Translation Research On Combating Antimicrobial Resistance
EC contribution
: € 2,999.445
: 36 months
Starting date
: 02/01/2008
Funding scheme
: Collaborative Project (Medium-scale focused research project)
: Methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus spp., Extended-spectrum, metallo- and acquired AmpC beta-lactamase producing Enterobacteriaceae, multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii
Contract/Grant agreement number
: 223031
Project web-site


The health care systems of most European countries are based on a continuum from acute care hospitals, through other health care facilities to the community. This framework provides the perfect opportunity for the wide-spread dissemination of high-risk resistant clones or genetic-resistant elements. The driving concept of TROCAR is to investigate the fundamentals of the epidemiology of new highly virulent multiresistant strains of MRSA, VRE, ESMAC-BL-producing Enterobacteriaceae, multidrug-resistant P. aeruginosa and A. baumannii will focus on three major strategic aims: 1. The definition of the major high-risk resistant clones based on an appropriate representative collection and new clinical strains obtained during molecular epidemiological studies, in hospitals and laboratories collaborating with their respective National Excellence Laboratories in European countries using a standardised protocol. 2. The promotion of collaborative European research to investigate, by genomic and proteomic approaches, specific traits associated with virulence, transmission, persistence and resistance of epidemic clones in comparison with non-epidemic clones as well as resistance determinants and their genetic location in horizontal gene transfer units and their genetic environment. 3.The development of bioinformatics tools to fully exploit the genomics data and allow the rapid identification of resistant strains with heightened epidemic potential. By combining the outputs of the project it will be possible to provide tools for monitoring the spread of key community and nosocomial pathogens, to provide the scientific basis for an early warning system when isolates of a particular epidemicity appear in the community and nosocomial settings, to create a knowledge base for combating epidemicity and virulence, to characterise specific genetic elements carrying genes encoding ESCMAC-BL, to identify potential reservoirs of antibiotic resistance genes amongst community and nosocomial pathogens involving multi-drug resistance and to establish the bioinformatic tools and infrastructure necessary to achieve the ultimate TROCAR goal: to recommend novel control measures to limit or prevent the spread of highly virulent multi-drug resistant clones: from molecule to preventive action.

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