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CONCORD


CONtrol of COmmunity-acquired MRSA: Rationale and Development of counteractions
EC contribution
: € 2.994.192
Duration
: 36 months
Starting date
: 01/11/2008
Funding scheme
: Collaborative project (Small or medium-scale focused research project)
Keywords
: Community-associated MRSA, pig-associated MRSA, MRSA, methicillin resistance, phage therapy, whole genome sequencing, comparative genomics, microarray, transcriptomics, mathematical modelling, population structure, virulence, Staphylococcus aureus
Contract/Grant agreement number
: 222718
Project web-site
: http://www.concord-mrsa.eu/

Summary:

Until recently, methicillin-resistant Staphylococcus aureus (MRSA) were confined to hospitals (HA-MRSA). However, community- and farm-associated MRSA (CA-and FA-MRSA) have developed as an important cause of infections. At present no effective strategies exist to combat these epidemiologically distinct types of MRSA.

CONCORD aim to explain the ecological success in the community and the farm environment of CA- and FA-MRSA in contrast to HA-MRSA in order to provide knowledge for the development of effective strategies to control the spread of these pathogens.

Epidemiology of CA- and FA-MRSA is complex and incompletely understood. To gain insight into the epidemiology of CA- and FA-MRSA and obtain contemporary isolates, small scale surveillance studies will be performed among patients in the 20 most populous EU countries, pigs from farms in major pig-exporting countries and among calves in important veal-calve raising countries.

Genomics data for CA-MRSA is limited and non-existent for FA-MRSA. Successful adaptation of MRSA to a new environment supposes either the acquisition of novel genetic determinants or the differential expression of native genes. Only two CA-MRSA isolates have been fully sequenced and the UMCU has sequenced a FA-MRSA isolate. Whole genome sequencing, comparative genome hybridization and transcriptomics will be used to understand the genetic adaptations of MRSA in the community environment.

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