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The aim is to address key pathogens and groups of pathogens causing major drug resistance problems through multi-disciplinary translational research, bringing basic research forward through clinical research to improved patient management and towards product oriented research on new diagnostic tests, treatments and prevention strategies.

The EU collaborative research strategy is focused around five main approaches:

Firstly, research into the basic phenomena of drug resistance, aim to better understand the molecular mechanisms of resistance, how resistance genes emerge and how they spread between bacterial species, how bacteria colonise and spread from individual to individual, how bacteria interplay with the host immune system and why bacteria cause disease. This type of new knowledge is then used to develop completely new treatment and prevention approaches, as successfully done for the respiratory pathogen Streptococcus pneumoniae, where novel targets for vaccines, drugs and diagnostics have been identified.

Secondly, epidemiological research unravels the wider clonal spread of multi-drug resistant strains over regions and continents with the aim to develop improved control and prevention tools. Multi-drug resistant Staphylococcus aureus (MRSA) spread in hospitals and the community, Vancomycin-resistant Enterococci (VRE), multidrug-resistant Pseudomonas aeruginosa, Extended-Spectrum-Beta-Lactamase (ESBL) producing Enterobacteriacea and the recent sharp rise in incidence of Clostridium difficile are subject to in-depth analysis.

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