Of all the illnesses known to man, cancer
remains one of the most dreaded and mysterious. Metastatic disease
is an especially difficult problem, and finding means of diagnosing
and treating such cancer has been one of the major goals of modern
This project sought to develop new medical
diagnostic and therapeutic tools, applying advanced techniques for
the preparation of nanosized powders to the synthesis of pharmaceutical-based
particle systems ("magnetites"). These new particles can
be coupled with man-made biomolecules and then act as magnetic targets
for advanced imaging and other techniques. New analytical methods
were also developed, and insights were gained into the biological
particle action at a sub-cellular level.
Furthermore, new animal models were developed
and have already been validated using the particles. Other findings
are of special importance as the use of low-field scanners at competitive
cost is of increasing importance for clinical diagnostics due to
changes in public health policy.
The new synthesis technique can operate
as a closed system, meaning almost all educts and additives can
be recycled, keeping it in line with current and future economical
and environmental standards. Partners see several medical applications
for their new particles and a very high market potential.