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Graphic element Research > Growth > Research projects > Previous projects > Medicine and Health > Purification of optical isomers by continuous chromatography
Graphic element Purification of optical isomers by continuous chromatography
     
 
A new simulated moving bed (SMB) chromatography technique including new chiral stationary phases (CSPs) and software are a step forward for Europe.
 

Chromatographic separation techniques are mainly used in the pharmaceutical industry for the purification of substances used in the preparation of drugs. The aim of this project was the development of a high-performance industrial-scale simulated moving bed (SMB) chromatography technique for preparative separation of optical isomers, including the development of, appropriate simulation software, and demonstration units.

The project objectives were fully met, resulting in a pilot system and a small industrial-scale prototype with an internal diameter 20cm. At the time of the project, the industrial-scale SMB plant was the largest in the world. The goal now, say partners, is to produce a machine with an internal diameter up to 1m. The CSPs developed by the partners are superior to those developed by the current market leader, a Japanese firm. The system also features reduced emission of dangerous organic solvents.

The potential applications for the new system can be seen in a widerange of areas, say partners, including the food, perfume and, pesticide industries. The results were already being exploited commercially before the end of the project.

Cordis RCN: 6609
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