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Sixth Framework Programme MAJOR PROJECTS LIBRARY - What's New?


The library contains an overview of Integrated Projects (IPs) and Networks of Excellence (NoEs) selected so far. The What's New? section features projects with new information such as links to websites, articles etc.

NB: The library does not yet include Information Society Technologies, or the parts of Aeronautics and Space, and Sustainable Surface Transport covered by the Energy and Transport DG.

Click a title below and then scroll down the page to see projects for that thematic priority.

Major Projects Library Home Page
Number of projects in the library
Life sciences, genomics and biotechnologies for health
Nanotechnologies and nanoscience, knowledge-based multifunctional materials, and new production processes and devices
Aeronautics and space
Food quality and safety
Sustainable energy systems
Sustainable surface transport
Global change and ecosystems
Citizens and governance in a knowledge-based society
European Atomic Energy Community - Euratom

Title: Targeting newly discovered oxygen-sensing cascades for novel cancer treatments Biology, equipment, drug candidates.
Project summary:   The application will aim at understanding the role of hypoxia and factors regulating it, in tumour development. These processes have been proven highly important for tumour progression and resistance to chemiotherapy. Because of their strong over-expression in solid cancer tumours this new knowledge may open a new therapeutic window. Strengths of this application stand on the strong academic-clinical-industrial interaction and the successful mobilisation of a diverse set of competence
Title: Mutant p53 as target for improved cancer treatment
Project summary:   The principal goal of this program is to characterise a subset of mutations in the p53 gene that bring about a gain of function (GOF). It is hoped that this information will be of use in the prediction of response to conventional chemotherapy, as well as in prognosis. In the long run, it is hoped that small molecular weight compounds, able to restore wild type function to the mutated molecules, will be optimised for use in cancer therapy.
Title: European Consortium for Stem Cell Research
Project summary:   EuroStemCell aims to build the scientific foundations required to take stem cell technology to the clinic. Combining the expertise of more than 100 researchers across 27 research groups in 14 partner institutions, the overarching aim is an integrated trans-European effort to develop well-characterised cell lines of therapeutic potential, derived from embryonic, neural, mesodermal and epithelial stem cells.

The ability to produce specialised cell populations at scale will create new opportunities for assignment of gene function, identification and validation of drug targets, pharmaceutical screening, toxicology testing, and, in the longer perspective, for repair of diseased or damaged tissue by cell transplantation.
Additional project information:   Project website  CORDIS News article 

Title: Novel molecular drug targets for obesity and type 2 diabetes
Acronym:   DIABESITY
Project summary:   The rapid increase in the prevalence of obesity, type-2 diabetes, and associated complications is a major global health problem. In Europe alone, approximately 33 million adults will be suffering from diabetes by 2010. Obesity, which is a major recognised risk factor for type-2 diabetes, is itself rapidly increasing in prevalence resulting in a "diabesity" epidemic. The current cost of type-2 diabetes in the European Union is 15 billion per year, and medical complications arising from diabetes account for up to 8% of total health costs in Europe. A component of our disposition to obesity is genetic, the biggest predictor of how obese you will be is how obese your parents are. For most people, neither dieting nor current pharmacological interventions are effective in achieving long-term weight reduction. Dieting is largely ineffective because once a chronically overweight state has been attained, our brains interpret dieting as a threat to survival, and the control systems in the hypothalamus of the brain reduce our metabolism and attempt to maintain body weight i.e. our brains "defend" our existing energy stores. Thus to treat diabesity, a way must be found to modulate the ways in which the brain controls metabolism, body weight and composition. The DIABESITY project aims to identify new genes implicated in obesity and develop strategies for validating these genes as targets for future pharmacological manipulation. We It will study how these genes interact with hypothalamic pathways that regulate appetite and metabolism using multiple approaches to establish the functional role of genes in regulating metabolism, body weight and composition. Using this approach the team aims to identify several new drug targets for the treatment and prevention of diabesity. The project, which started in January 2004, will run for 5 years and gathers 27 partners (from 24 participating institutions).
Additional project information:   Project website  Commission News Alert 
Title: Web accessible MR decision support system for brain tumor diagnosis and prognosis, incorporating in vivo and ex vivo genomic and metabolic data
Project summary:   This proposal aims to provide a decision support tool to aid the diagnosis and staging of brain tumors using 1H brain Magnetic Resonance Spectroscopy. This would facilitate the development of evidence-based clinical decision-making in this area. Strong points were the integration of technologies in the consortia, the quality of the proposed S &T and the leading role of SME.
Title: Rational Treatment Strategies Combating Mitochondrial Oxidative Phosphorylation (OXPHOS) Disorders
Project summary:   This project aims at tackling defects in mitochondrial oxidative phosphorylation, which lead to multi-system disorders affecting tissues and organs with high energy demand. Disorders of respiratory chain complex I, complex IV, of mitochondrial DNA maintainance and of mitochondrial protein synthesis will be investigated using a scheme articulated around 4 nodes: clinical aspects of OXPHOS disease; pathophysiology; OXPHOS assembly and regulation; therapies' development. By putting an emphasis on translational research, the overriding aim of the project is to provide a platform for the development of effective treatments for OXPHOS disease, that can have a real and sustained impact on the lives of patients, including children. A better knowledge of mitochondria in general should also have an impact in other research areas, for instance human development and ageing, or neurodegenerative disorders, which represent a high public health interest. 12 partners, of 9 countries including CZ, are involved in the project. No SME is at present included as full partner, but 4 SMEs are associated to the network, in training activities, development of new chemical entities and web design. It is foreseen to engage other SMEs during the course of the project.
Title: Advanced molecular tools for array-based analyses of genomes, transcriptomes, proteomes, and cells
Acronym:   MolTools
Project summary:   This project aims to deliver a wide range of novel microarray technologies and applications. Microarrays are used for high throughput analyses of genes, transcripts, proteins and cells.
Additional project information:   Project website  Europa news article 
Title: Adult mesenchymal stem cells engineering for connective tissue disorders. From the bench to the bed side
Acronym:   GENOSTEM
Project summary:   The proposal deals withautologous adult mesenchymal stem cells to be used in the field of connective tissue disorders such as osteoarthritis, rheumatoid arthritis, bone factures, tendon and cartilage injuries etc.
Additional project information:   Project website  CORDIS News article 
Title: Selection and development of Microbicides for mucosal use to prevent sexual HIV transmission / acquisition.
Project summary:   The main objective of this 4 years IP is the development, up to clinical phase I, of a specific HIV microbicide for the prevention of sexual transmission/acquisition of HIV, based on the interruption of viral replication at the mucosal level.
Title: Selective targeting of angiogenesis and of tumor stroma
Project summary:   The applicants propose to develop novel strategies to address tumour traetment by targeting the tumour-associated vasculature. Based on a stringent 20 workpackages step-by-step proposal, the applicants propose to go all the way from target identification through target validation to clinical implementation and validation.
Title: Mucosal Vaccines for Poverty Related Diseases
Acronym:   MUVAPRED
Project summary:   The aim of this project is to develop mucosally delivered vaccines against HIV and TB which will induce local immunity able to neutralise the pathogens at their port of entry and systemic immunity able to prevent systemic spread of the infection.
Additional project information:   CORDIS News article  Commission News Alert 
Title: Development of a novel approach in hazard and risk assessment or reproductive toxicity by a combination and application of in vitro, tissue and sensor technologies
Acronym:   ReProTect
Project summary:   The project foresees the development of novel cell-based in vitro methods in toxicological assessment. Relevant in vitro models are expected to be developed and subsequently validated, impacting positively on the policy support and development (REACH system for example). The increase of cell sustainability has been well addressed, as are the areas of stem cell research, array technologies, sensor development and definition of markers for toxicity. The development of a conceptual framework and the activities of the technology scouts is expected to move the field beyond state of the art. The proposal will undergo a thorough ethical review in December 2003 as one workpackage is focussing on human embryonic stem cells.
Additional project information:   Project website 
Title: Integrated technologies for in-vivo molecular imaging
Project summary:   This project brings together a multidisciplinary team (engineers, physicists and biologists) focused on developing and applying high resolution methods of in vivo molecular imaging. The development of these new techniques and probes will enable scientists to solve biological questions on the sub-cellular, cellular and whole small animal (mouse) level.
Title: Genetics for Healthy Ageing
Project summary:   The aim of the project is to identify genes involved in healthy ageing and longevity, allowing individuals to survive to advanced old age in good cognitive and physical condition and in the absence of major age-related diseases. To achieve this aim, demographers, geneticists, epidemiologists, molecular biologists, bioinformaticians, and statisticians collaborate in this IP. They will collect and analyse tissue samples from an unprecedented high number of 2550 sibpairs older than 90 years of age and compare them to the same number of younger controls. Analysis will include a genome scan by microsatellites, linkage disequilibrium mapping using SNPs, positional cloning, mutational analysis, detailed analysis of chromosomal regions already suggested to be involved in ageing and longevity, and genotyping of mitochondrial DNA. Comprehensive data analysis will combine advanced postgenomic and bioinformatic approaches to identify gender-specific genes involved in healthy ageing and to develop innovative mathematical and statistical models capable of combining the genetic data with demographic characteristics, health status, socio-economic factors, and life style habits. The participating SME is specialised in high-throughput approaches for studying gene expression by using DNA micro-array technology. 22 partners from 9 EU Member States and one partner from Poland are involved in the project.
Title: Extracellular Proteases and the Cancer Degradome: Innovative Diagnostic Markers, Therapeutic Targets and Tumour Imaging Agents
Project summary:   The main aims include the definition of new molecular targets for drug design, the development of novel specific interventions that are based on thorough knowledge of the pathophysiology of proteases, the identification of new molecular diagnostic and prognostic indicators of patient risk that can improve health care delivery. If successful, this project will enable, for the first time, a rational basis for developing inhibitors of specific proteases in selected cancers.
Additional project information:   Project website  Europa news article  CORDIS News article 
Title: European integrated project on spinocerebellar ataxias: Pathogenesis, genetics, animal models and therapy
Acronym:   EUROSCA
Project summary:   The project focuses on autosomal dominant SpinoCerebellar Ataxias (SCA), ranging from basic science to clinical applications. In particular, it will establish a CAPIT-SCA (Core Assessment Programme for Interventional Therapies) clinical scale, maintain a SCA registry, perform research on genetic modifying factors in SCA, develop disease models and pursuit novel therapeutic strategies based on a detailed understanding of the gene role and function. This will be the most ambitious international project on dominant SCA, which will pose Europe in the leading position in this field of research. The consortium gathers 22 participants, including 2 ACC partners (HU, PL). An SME has been foreseen, but has not yet been included as partner. This SME is supposed to screen for and provide small molecules for pre-clinical development of active compounds against neurodegene-ration.
Additional project information:   Project website  CORDIS News article 
Title: The Development of Immunotherapeutic Strategies to Treat Haematological and Neoplastic diseases on the Basis of Optimised Allogeneic Stem Cell Transplantation
Acronym:   ALLOSTEM
Project summary:   This proposal aims to solve the medical problems associated with allogenic hematopoietic stem cell transplantation and to enhance the immunotherapeutic effects of allogenic stem cell transplantation.
Additional project information:   Project website 
Title: Abnormal proteins in the pathogenesis of neurodegenerative disorders
Project summary:   This project studies protein aggregation in all common neurodegenerative disorders including Alzheimer's disease, Huntington's Chorea, frontotemporal dementia, Lewy body dementia, transmissible spongioform encephalitis, Parkinson's disease, and amyotrophic lateral sclerosis. The planned research ranges from biochemistry of protein aggregates, gene discovery, human genetics and tissue, to studies on model organisms, cell biology and proteomics, and further to clinical measures including brain imaging, the development of diagnosis and the discovery of novel drug targets and therapies. The consortium gathers 36 participants. One ACC partner (PL) is included. Co-ordination and management is provided by VERUM Foundation, a private non profit organisation based in DE. Two SMEs (Cellzome AG and EVOTEC Neurosciences GmbH) are included in the project.
Title: An Integrated project for the design and testing of vaccine candidates against tuberculosis: Identification, development and clinical studies
Acronym:   TB-VAC
Project summary:   Taking advantage of the complete sequencing of the Mycobacterium tuberculosis genome and the availability of new research tools, the project joins 30 leading European research institutions with the objective of optimising and developing TB vaccines better than the available BCG.
Additional project information:   CORDIS News article  Commission News Alert 
Title: Biocrystallography (X) on a Highly Integrated Technology Platform for European Structural Genomics
Acronym:   BIOXHIT
Project summary:   The main objective of BIOXHIT is to exploit high-throughput structure determination using X-ray crystallography with synchrotron radiation. It focuses on the development of hardware synchrotron technologies, high throughput crystallisation technologies and data collection / processing, thereby developing standardisation of methodologies in synchrotron data acquisition and treatment.
Title: Novel approaches to pathogenesis, diagnosis and Treatment of autoimmune diseases based on new insights into thymus-dependent self-tolerance
Project summary:   This application proposes to use a novel approach for the treatment of autoimmune disease by targeting the restoration of central self-tolerance in the thymus. The project would concentrate on type 1 diabetes as a model of autoimmune disease.
Additional project information:   Project website 
Title: Genome-Based therapeutic drugs for depression
Acronym:   GENDEP
Project summary:   Will analyse transcriptomics and proteomics to identify new targets for tailor-made drugs to treat depression. Will predict response to psychiatric drug treatment and the reduction of adverse events from such drugs. Looks at the roles of ethics committees, the attitudes of clinical service users and service providers.
Additional project information:   Project website 
Title: Further improvement of radiotherapy of cancer through side effect reduction by application of adult stem cell therapy
Project summary:   The project has the goal to reduce the level of normal tissue complications after radiotherapy. The strategy chosen by the consortium is to use isolated human stem cells form different sources including bone marrow/blood and epithelial tissues to repair damaged normal tissue. The intention is to optimise stem cell culture conditions and establishing the best scheduling of radiation treatment and cellular infusion to enable recovery of specific organs from radiation exposure.
Title: Translational and Functional Onco-Genomics: from cancer-oriented genomic screenings to new diagnostic tools and improved cancer treatment.
Project summary:   The project will identify and characterise novel cancer-related genes expected to play an important role in the diagnosis and treatment of cancer. Up-or down-regulation of identified genes in models of tumour aggressiveness will provide proof-of-concept validation of their potential usefulness as new molecular targets for drug screenings. The diagnostic potential of the candidate cancer genes will be evaluated and validated by systematic analysis of tumour samples with different techniques
Title: Regulation of mitosis by phosphorylation - A combined functional genomics, proteomics and chemical biology approach
Acronym:   Mitocheck
Project summary:   The regulation of cell proliferation is crucial to understand several human diseases, especially cancer. The goal of Mitocheck is to generate a catalogue of kinase substrates that play a crucial role in mitosis and that might be disregulated in cancers
Additional project information:   Project website  CORDIS News article 
Title: Protein kinases - Novel Drug Targets of Post Genomic Era
Project summary:   The overall objective of the project is to develop Proteinkinase inhibitors based on a combination of design and screening by using natural compounds from the European biosphere in addition to chemical libraries. The proposal aims to develop the PK inhibitors to a pre-clinical stage, including testing of efficacy, potency and selectivity in both in vitro and in vivo studies. The integration of the necessary scientific disciplines is very well structured comprising structural biology, in silico screening, functional biology, design ann scaling of assays, robotic high-throughput Protein expression, in vivo pharmacological screening, pharmacokinetics, toxicological studies and access to clinical facilities.
Additional project information:   Project website 
Title: New molecules in mood disorders: a genomic, neurobiological and systems approach in animal models and human disorder
Acronym:   NEWMOOD
Project summary:   This project aims at studying the biological factors underlying depression. It promises to create conceptually novel, targeted patient-dependent approaches for the treatment of depressive disorders by addressing and deciphering the underlying genetic factors and molecular mechanisms of the disease. The strength of the proposal lies in the integration of the clinical and experimental aspects of depression. Considering the high incidence of depression and the resulting individual as well as societal burdens, the successful project may have a major impact on public health. This geographically well distributed network gathers 13 participants including three ACC partners (EE, HU, PL). SMEs are foreseen, but have not yet been included as participants.
Additional project information:   Europa news article  CORDIS News article  Nature Science Update article 
Title: Targeting replication and integration of HIV
Acronym:   TRIoH
Project summary:   This project aims at the development of novel anti-HIV molecules targeting the replication cycke and the integration process of HIV. In addition, the viral entry will be addressed, the starting point of the infection. Multidisciplinary proteomic approaches are to be used to study the different steps in the viral cycle. As potential inhibitors synthetic compounds, peptides, DNA- and RNA based systems will be designed and the cellular factors involved in productive HIV and SIV will be generated to enable testing of the inhibitors in Rhesus monkeys and should allow to develop some candidate compounds ready for clinical trials.
Additional project information:   Project website 
Title: Identification of risk genes for atherothrombosis in coronary artery disease by transcriptome and proteome analysis and high throughput exon resequencing
Project summary:   The ambitious project will generate population genetics data that will provide new information on the cause of CVD and atherotrombosis though the identification of genes and gene variants, proteins and intracellular signalling pathways that are contributing. To reach this objective the consortium brings together over than 160 staff members of 16 departments working in CAD and will create a virtual European Cardiovascular Genetics Institute. 16 partners (3 SMEs), of 6 EU countries, are involved in the project. Gender balance concerning the participants is achieved, 45 % of the personnel are women. Integration and expertise will lead to innovation and invention, which has the intent to be exploited by the associated SMEs and the pharmaceutical sector. This is a highly focused, well structured and clearly outlined integrated project with an good mobilisation of resources and an high quality of management.
Title: AIDS vaccines integrated project
Project summary:   The aim of this project is a joined effort of European and African research groups to develop an effective vaccine against HIV/AIDS. The consortium will conduct phase I clinical trials in Europe to test new preventive and therapeutic HIV vaccines. The novelty of the HIV/AIDS vaccines to be developed by AVIP lays on the combination of both structural and regulatory HIV genes/products. Priority has been given to 4 combined vaccine candidates, in which single antigens already underwent or are starting phase I studies or are under GMP development.
Title: Functional Genomics in Engineered ES cells
Project summary:   Self-renewal, commitment and differentiation of murine embryonic stem cells will be investigated in this project using a functional genomics approach to discover genes, regulatory pathways and fundamental molecular and cellular mechanisms. This ambitious project is industry-led and has a number of SMEs.
Title: Zebrafish Models for Human Development and Disease
Project summary:   The zebrafish is a model organism whose potential for the functional analysis of genes has not yet been fully realised. This project uses high throughput tools, technologies and approaches (e.g. mutagenesis screening, forward genetics and targeted knock-out) in this non-mammalian vertebrate to harvest large data sets on gene functions underlying development and disease.
Title: European Microbicides Project
Acronym:   EMPRO
Project summary:   This project aims to develop new topical microbicides that block entry of HIV at mucosal sites with the aim of establishing a pipeline of candidate microbicides while taking selected microbicides through Phase I clinical trial.
Additional project information:   CORDIS News article 
Title: Methods and advanced equipment for simulation and treatment in radio-oncology
Project summary:   The present project proposes innovative research in software development and advanced sensor technology to validate in clinical conditions the specific aspects of Intensity Modulated Radiation Therapy employing photons, protons and advanced brachytherapy. The major strength of this project was its potential likelihood to help solve limitations of current radiotherapy technology and clinical application and the well- suited partnership.
Title: Recombinant Pharmaceuticals from Plants for Human Health
Acronym:   Pharma-Planta
Project summary:   The project aims to use plants as expression systems to produce recombinant antibodies for use in medicine. It includes consideration of regulatory requirements, GMP and pre-clinical toxicity testing, and new strategies for a second generation of recombinant molecules.
Additional project information:   Project website  CORDIS News article  BBC news article 
Title: Genome-Wide Discovery and Functional Analysis of Novel Genes in Lymphangiogenesis
Project summary:   The aim of this project is to discover novel genes important for lymphatic vascular versus blood vascular development and function. Mouse and zebrafish models will be used to identify novel genes involved in lymphangiogenesis processes in a functional genomics approach.
Title: Integrated Membrane Protein Actions
Project summary:   The 3D-structures of integral membrane proteins are of great interest both in terms of fundamental understanding and biomedical application. The E-MeP structural genomics programme seeks to develop high throughput technology for membrane proteins and expression systems to obtain high-resolution structures of such membrane proteins. The project will incorporate many innovative technologies (e.g. membrane protein bioinformatics and EM methods), and also intends to address the challenge of generating milligram-scale production of eukaryotic membrane proteins, which up to now is seen as a major bottleneck in membrane protein research.
Title: Functional Proteomics: Towards defining the interaction proteome
Acronym:   Interaction Proteome
Project summary:   This project focuses on protein-protein and protein-ligand interactions. The project will use large screens on selected biologically and medically relevant target systems by applying tools such as mass spectrometry technology, cryo-electron tomography and fluorescence labelling within cells to visualise the proteins and their complexes in the cellular environment.
Additional project information:   Project website  Europa news article  Max Planck Society Press Release 
Title: Innovative Chemochine-Based Therapeutic Strategies for Autoimmunity and Chronic Inflammation
Acronym:   INNOCHEM
Project summary:   The general objective of INNOCHEM is to develop innovative chemokine-based therapeutic strategies for autoimmunity and chronic inflammation. The project is based on the scientific excellence of the applicants, which have made major recognized contributions to the field since the very beginning of chemokine discovery, and on the construction of shared technological platforms. This will include: i) proteomics and ii) transcriptional profiling for the outline of the "chemokinome" in pathophysiological conditions and identification of new antagonists; iii) molecular modelling of agonist/antagonist receptor or agonist/inhibitor interaction, for pharmacology and drug design; iv) gene modified mice for target validation in autoimmune disorders. Genetic, structural, biological, and immunopathological studies will provide a framework for the development of innovative chemokine-based therapeutic strategies. The therapeutic approaches to be investigated are innovative and not limited to conventional antagonists. These will include decoy receptors, agonist binders, and non-competitive allosteric inhibitors. In addition to academic groups, therapy-oriented research will include 3 biotech SMEs, 1 medium and 2 big Pharma companies. The companies involved develop complementary non-overlapping approaches to target the chemokine system with recombinant and low molecular weight molecules. INNOCHEM is expected to conduct a "proof of principle" clinical study in volunteers in the first 18 months. The ambition of this project is to re-establish European leadership in basic and applied chemokine research by integrating academic and industrial cutting edge groups to develop innovative therapeutic strategies against autoimmunity and chronic inflammatory disorders.
Additional project information:   Project website 
Title: Innovative Medicines for Europe
Acronym:   InnoMed
Project summary:   The discovery and development of new drugs is very costly and attrition rates are high. Initiatives to reduce the rate of attrition during later phases are clearly desirable and if successfully implemented will reduce development costs. The InnoMed proposal addresses the complex issues associated with the future of biomedical research in the EU, and addresses ways of achieving accelerated development of, safe and more effective medicines, aiming to revitalize the European biopharmaceutical research environment. InnoMed s wide consortium base, being led by the European Federation of Pharmaceutical Industry and Associations (EFPIA), guarantee s a commitment from all the stakeholders needed to change the process of drug development in Europe. The course for addressing the necessary changes is to first develop a Strategic Research Agenda (SRA) that will encompass the whole path from discovery of a new drug target to the validation and approval stages of a new drug compound. This SRA is already in the process of being elaborated involving all the relevant stakeholders via meetings and workshops and four key bottlenecks in the drug development process have been identified:
  • Safety
  • Efficacy
  • Knowledge Management
  • Training and Education
The elaboration of this SRA will be performed in a first stage within the frame of the European Technology Platform (ETP) and, will, of course, be subject to regular updating. The resulting comprehensive strategy with a detailed roadmap will reveal a variety of concrete research topics to be deployed within the ETP. The implementation of these research topics will deliver added value to the drug discovery and development process and to individual stakeholders. InnoMed will demonstrate the validity of the approach through two research sub-projects: AddNeuroMed, which will develop and validate novel surrogate markers based upon in vitro and in vivo models in animals and humans, using Alzheimer s disease as a testing platform. PredTox will deliver new biomarkers of toxicity and a greater understanding of mechanisms of toxicity.
Title: Novel molecular diagnostic tools for the prevention and diagnosis of pancreatic cancer
Acronym:   MolDiag-Paca
Project summary:   The MolDiag-Paca Integrated Project proposes to develop novel molecular diagnostic approaches for the prevention, early diagnosis and risk stratification of pancreatic cancer. Based on large scale transcriptome, genome and proteome analyses, novel molecular techniques will be developed for the detection of cancer cells or preneoplastic cells in minimal amounts of clinical tissue (fine needle biopsies) or fluid (pancreatic/duodenal juice or serum) samples. Novel tools will include transcript and epigentic analyses, chip technology, single or multiple marker protein studies, DNA/RNA PCR analyses, serum proteomics and molecular imaging. The project benefits from large multinational European trials such as ESPAC or EUROPAC. At the end clinical trials of novel diagnostic tools developed should be initiated.
Title: Concerted Safety & Efficiency Evaluation of Retroviral Transgenesis in Gene Therapy of Inherited Diseases (CONSERT)
Acronym:   CONSERT
Project summary:   CONSERT will integrate leading European activities for a structured implementation of novel therapies using genetically enhanced postnatal stem cells, with focus on the treatment of monogenic immunodeficiencies, hemoglobinopathies, anemias and storage disorders. CONSERT will develop and evaluate methods for genetic stem cell modification with wide implications for many other disorders including viral infection and cancer. A central and exceptional theme of our work is an unbiased safety and efficiency evaluation of the key technology used in the genetic modifications of replicating somatic cells: retroviral vector-mediated transgenesis.

Lenti-, spuma- and gammaretroviral vectors will be tailor-made for target disorders and tested for potency and safety in preclinical disease models. Designed with a translational aim, basic studies in stem cell biology and selectable marker technology will complement this research.

In parallel, molecular studies in precise cell systems and animal models will provide a deeper mechanistic understanding of transgene-host interactions. Supervised by a proactive ethical project, CONSERT will stimulate a competitive and complementary evolution of biomedical academia, clinics, innovative health service providers, and associated training opportunities.

Additional project information:   Project website 

Title: Beta Cell Programming for Treatment of Diabetes (BETACELLTHERAPY)
Project summary:   Our consortium with leading teams in molecular, developmental and functional biology has worked out an integrated program to generate insulin-producing beta cells in therapeutic quantities and established interactions to translate knowledge to associated bioindustry and multicenter clinical trials, as well as to society. Nature's biologic program to develop and preserve a functional beta cell mass throughout life is taken as platform for directing strategies towards laboratory production of a therapeutic beta cell mass. Beta cells will be derived from embryonic stem cells and from transdifferentiating liver, intestinal and pancreatic exocrine cells. Functional genomics will be used to compare phenotypes of beta cells from new sources with those isolated from the pancreas. This analysis will direct further research and judge on the start of preclinical testing. It will also generate new tools and quality control criteria that will allow standardization of ongoing trials and adjustments in graft biology to increase its long-term survival and function in patients.

Additional project information:   Project website 

Title: Gene therapy: an Integrated Approach for Neoplastic Treatment (GIANT)
Acronym:   GIANT
Project summary:   Translation of genetic knowledge from the Human Genome into disease-specific therapy for untreatable congenital and acquired diseases is now reality. However, the gene therapy vectors currently used in experimental settings can be developed for safe clinical application only if fundamental problems are solved: ie the limitation of vector dose by attachment targeting and expression control and a decrease of non-specific toxicity. Minimisation of vector immunogenicity (stealthing) is necessary to reduce bloodstream and immune-mediated reduction of effective vector concentration. In the GIANT project, targeting and stealthing of both viral and non-viral vectors will be used to select candidates for testing in Phase I clinical studies. GIANT will concentrate firstly on one uniform model system and disease target (prostate carcinoma) for vector testing standardisation and in vitro, preclinical and clinical vector comparison. We will use a clinically approved vector backbone of adenoviral constructs re-targeted to prostate cancer via surface antigens, and hybrid prostate targeted promoters. The consortium includes a GMP vector production facility and clinical facilities with scientific and ethical permission to carry out human cytotoxic gene therapy trials, guaranteeing the immmediate translation of selected vectors into the clinical testing. The biomaterials obtained will serve to develop new assays for vector distribution, efficacy and monitoring of the immune response against various vector systems.

Additional project information:   Project website 

Title: Rational design and standardized evaluation of novel genetic vaccines (COMPUVAC)
Acronym:   COMPUVAC
Project summary:   Recombinant viral vectors and virus-like particles are considered the most promising vehicles to deliver antigens in prophylactic and therapeutic vaccines against infectious diseases and cancer. Several potential vaccine designs exist but their cost-effective development cruelly lacks a standardised evaluation system. On these grounds, COMPUVAC is devoted to (i) rational development of a novel platform of genetic vaccines and (ii) standardisation of vaccine evaluation. COMPUVAC assembles a platform of viral vectors and virus-like particles that are among today's most promising vaccine candidates and that are backed up by the consortium's complementary expertise and intellectual property, including SMEs focusing on vaccine development. COMPUVAC recognises the lack of uniform means for side-by-side qualitative and quantitative vaccine evaluation and will thus standardise the evaluation of vaccine efficacy and safety by using "gold standard" tools, molecular and cellular methods in virology and immunology, and algorithms based on genomic and proteomic information. "Gold standard" algorithms for intelligent interpretation of vaccine efficacy and safety will be built into COMPUVAC's interactive Genetic Vaccine Decision Support System, which should generate (i) vector classification according to induced immune response quality, accounting for gender and age, (ii) vector combination counsel for prime-boost immunisations, and (iii) vector safety profile according to genomic analysis. Since one of our "gold standard" antigens is the West Nile virus (WNV) envelope protein, an additional aim of COMPUVAC is to generate a candidate vaccine against WNV. As end products, our vector platform and "gold standard" tools, methods and algorithms will be available to the scientific and industrial communities as a toolbox and interactive database which standardised nature should contribute to cost-effective development of novel vaccines with validated efficacy and safety profile

Title: Design of small molecule therapeutics for the treatment of Alzheimer s disease based on the discovery of innovative drug targets
Acronym:   ADIT
Project summary:   Alzheimer s disease (AD) is the most common degenerative dementia, with enormous unmet medical, social and economic needs. ADIT aims at the development to the preclinical stage of novel chemical entities having specific neuroprotective activity. Proteomics and transcriptomics methodologies and sophisticated bioinformatics are used to identify proteins involved in Amyloid- -mediated neurodegeneration. In vitro, in vivo and ex vivo experiments are carried out in order to identify and validate drug targets ready for bioassay design and lead discovery. The ambitious final goal of the project is the progression of two drug candidates towards clinical development.

Additional project information:   Project website 

Title: Role of p63 and related pathways in epithelial stem cell proliferation and differentiation, and in rare EEC-related syndromes
Acronym:   Epistem
Project summary:   The main goal is to study the role of p63 (a key molecule in embryonic development) and related pathways, in epithelial stem cell proliferation and differentiation, and in rare Ectrodactyly Ectodermal dysplasia - clefting (EEC) - related syndromes, for which there is currently no cure. The focus is to generate new knowledge and translate it into applications that enhance human health. Both fundamental and applied research will be involved. The project integrates multidisciplinary efforts to understand the molecular basis of factors involved in epidermal stem cell generation, maintenance and differentiation, and in skin disease.
Additional project information:   Project website 
Title: Novel Testing Strategies for In Vitro Assessment of Allergens.
Acronym:   Sens-it-iv
Project summary:   Allergies to sensitising agents are steadily increasing. Risk assessment for potential skin- or lung-sensitisers, completely depends on animal testing. The overall objective of Sens-it-iv is to produce in vitro alternatives for these assays, and develop them upto the level of pre-validation. Besides reducing animal experimentation, an increase the accuracy of predicting sensitising potencies is expected. In vitro mechanisms, relevant for in vivo sensitisation, will be identified at the level of human lung or skin epithelial cells (EC), dendritic cells (DC) and T-cells. These efforts imply specific scientific (S) and technologic (T) objectives: Existing data on sensitising, irritating and toxic compounds are collected (S). In vivo changes induced by selected compounds in the specified cell types are described using functional genomics (S). Similarly, the impact of compounds on individual cells, and the interaction between these cells is assessed in vitro (S). The physico-chemical properties of chemicals responsible for metabolic activation and hapten-formation are determined (S). The data are collected in an Inductive Database allowing queries for data patterns and predictive models (T). Mechanisms specifically involved in skin and respiratory sensitisation are identified using bio-informatics (S). The information is used to adapt/improve existing techniques, and to develop organotypic models derived from human cells assays (T). A proof of principle is established on a set of selected skin and respiratory sensitisers, irritants and toxic compounds (T). Sens-it-iv is innovative primarily by the coordinated and extensive characterisation of the impact of compounds on cell-cell interactions for identification of the key mechanisms of sensitisation. Consistency with existing and ongoing projects, and optimal exploitation of these achievements is ensured by the involvement of ECVAM, COLIPA, ECOPA, IVTIP and OECD in various levels of the project.
Title: Optimization and pre-validation of an in vitro test strategy for predicting human acute toxicity
Acronym:   A-CUTE-TOX
Project summary:   Validated alternative test methods are urgently required for safety toxicology of drugs, chemicals and cosmetics. Both REACH and the 7th amendment of the Cosmetics Directive call for the broad replacement of animal experiments on a short-term. While some animal tests for topical toxicity have been successfully replaced one by one by alternative methods, systemic toxicities require new test strategies in order to achieve an adequate safety level for the consumer. The aim of A-Cule-Tox is to develop a simple and robust in vitro testing strategy for prediction of human acute systemic toxicity, which could replace the animal acute toxicity tests used today for regulatory purposes. The involvement of ECVAM and that of regulators (such as European Chemicals Bureau) guarantees the follow-up. The Scientific objectives of the project are: 1. Compilation, critical evaluation and generation of high quality in vitro and in vivo data for comparative analysis. 2. Identifying factors that influence the correlation between in vitro toxicity (concentration) and in vivo toxicity (dosage), and to define an algorithm that accounts for this. 3. Explore innovative tools and cellular systems to identify new end-points and strategies to better anticipate animal and human toxicity. 4. To design a simple, robust and reliable in vitro test strategy amenable for robotic testing, associated with the prediction model for acute toxicity. The project will develop the concepts required to compose testing strategies via the continuous implementation of novel in vitro and in silico alternatives. This approach requires the dimension of a transnational Integrated Project, involving prominent toxicity research groups in the EU, close monitoring by and input from the regulatory community and professional managerial steering. In return, it offers the realistic opportunity to achieve a substantial reduction of animal experiments in acute systemic toxicity assesments.
Title: RNA Interference Technology as Human Therapeutic Tool
Acronym:   RIGHT
Project summary:   The RIGHT project aims at exploiting the vast potential of RNA interference (RNAi) for human therapy, based on an advanced understanding of the underlying mechanisms. Rational and selective approaches will be taken to generate efficient RNAi reagents, and strategies will be developed for efficient delivery to cells and tissues of diseased organisms. RIGHT combines the strengths of 5 synergistic competence domains to reach this ambitious goal and overcome key technological barriers such as undesired interferon response and insufficient delivery, stability and targeting of RNAi to the appropriate cells. 1. The understanding of the molecular processes associated with RNAi and microRNA will be improved as a basis for the development of molecular strategies and tools enabling the successful application of RNAi for human therapy. 2. Improved inhibitors including RNAi mimics and potent delivery reagents will be chemically synthesized and extensively tested in cell culture and living organisms in order to increase sensitivity, specificity and cost-effectiveness and reduce side effects. 3. Potent viral or non-viral RNAi vectors will be generated and their features evaluated in relation to their chemical counterparts. 4. For the development of a drug, synthetic or genetic RNAi reagents will be assessed with pharmacokinetic methods, and extensive phenotyping of treated animals will be performed. 5. Selected disease models will be used for the paradigmatic assessment of RNAi as a therapeutic tool to generate RNAi leads for clinical tests. The RIGHT partnership of leading research institutions and biotech SMEs will deliver tools such as new enabling technologies, chemically synthesized and genetically generated inhibitors with efficient delivery properties. Within 4 years, the potential of RNAi to diagnose and successfully treat severe unvanquished diseases will be demonstrated and proof of principle provided for the value of RNAi as a therapeutic tool in living organisms.

Additional project information:   Project website 

Title: A multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community
Acronym:   GABRIEL
Project summary:   Europe wide study to examine causes of asthma

Imperial College London and Munich University are to take the lead in a €11 million (£8 million) study to examine how genetics and environment influence the development of asthma in Europe.

The GABRIEL project, funded through an EC Framework 6 grant, involves over 150 scientists from 14 European countries, using the latest research across a variety of disciplines, including genetics, epidemiology and immunology, to identify key factors in the development of asthma.

Professor Bill Cookson, from Imperial College London, and co-ordinator of the study, said: “Asthma is the major chronic childhood illness in Europe. The cost of the childhood asthma to the European Community is more than €3 billion each year. Although effective therapies of mild asthma exist, the 10% of children with severe disease account for 60% of this expense. Even when treatment is effective, it is not able to cure the disease.”

“Asthma is due to a combination of genetic and environmental effects. It runs strongly in families. It was rare a hundred years ago, but is increasingly common in developed societies across the world. A rural environment is still strongly protective against the disease.” “We hope this study will help us identify just how genes and the environment cause the development of asthma. The hope is that we in GABRIEL will be able to identify both risk and protective factors, with the long-term aim of preventing the illness.”

Professor Erika von Mutius from Munich University and co-leader of the project added: “Previous studies have shown the causes of asthma are diverse with many genetic and environmental factors all potentially having an impact. Traditionally it has been hard to analyse all the genetic and environmental information but the latest developments in areas such as genomics and bioinformatics now allow us to make sense of huge and complicated datasets.”

As well as looking at genetic and environmental interactions, GABRIEL will study the molecular basis for environmental factors which can increase the risk of industrial asthma, identify the agents which protect strongly against asthma in rural and farming communities and use genetics, genomics and proteomics to discover novel genetic and microbial factors that cause or protect against asthma.

Professor von Mutius added: “One particular area we will be looking at is the ‘hygiene hypothesis’, a theory which argues a lack of exposure to microbes in early childhood may cause an increased risk of developing asthma and allergies. Earlier work has indicated this may be the case, but we hope the scale of GABRIEL will allow us to properly test the hypothesis and to identify the responsible agents.”

GABRIEL will also develop model systems to investigate the molecular basis of genetic and environmental interactions which influence asthma, and use these model systems to translate novel findings into means of prevention and treatment for asthma.

The project will test genetic factors in over 40,000 subjects with childhood or adult asthma, with data from environmental factors such as tobacco smoke, air pollution, nutrition, allergen exposure and industrial agents.

Professor von Mutius has observed “This type of very large-scale study can only be carried out with International co-operation. We are most fortunate that we are able to carry out the GABRIEL project within Europe, with its wide diversity of environments and genes and yet its shared scientific heritage.”

Professor Cookson said that “GABRIEL would not be possible without European Community funding. It allows us to draw on the best of asthma and genetic research from many countries. The protective effect of a rural childhood indicates that asthma is a potentially preventable illness. We hope that GABRIEL will lead us to a clearer idea of what we may be able to use to prevent the disease from appearing”.

Additional project information:   Project website 

Title: Live attenuated replication-defective influenza vaccine
Acronym:   Fluvacc
Project summary:   We propose to develop an intranasal vaccine against pandemic influenza, based on reverse genetics. This technology will permit to rapidly generate replication-defective strains from new emerging influenza viruses that are safe and effective. We will generate reassortant vaccine viruses containing the surface glycoproteins from emerging wild-type influenza strains and the internal proteins of a master strain lacking the NS1 gene . The efficacy and safety of the resulting vaccine strains will be evaluated in chickens and ferrets. In addition we will scale up our production technology based on Vero cells. To establishing a fast and efficient downstream process we will further develop and scale up our purification method on monolithic columns. Subsequently, after toxicological evaluation of the cGMP produced candidate vaccines, clinical studies will be performed in healthy volunteers. The complementary constellation, the quality of the partners, efficient project management and availability of the combined resources will enable to successfully reach the goals of this project. It will allow the SMEs to significantly shorten the time necessary for the preclinical development phase and will bring the proposed chimeric vaccine viruses a major step closer to a marketable stage. Therefore, the project will contribute to the integration of partners in European research networks and, by its highly innovative features strengthen the European research. Through the involvement of partners from the Czech republic and from Slovenia this project contributes to the integration of new member states. Due to the enormous market potential, significant earnings can be expected. The patents, virus strains and technologies generated through theseproject will allow the SMEs to negotiate significant upfront, licensing and royalties payments from pharmaceutical companies.

Additional project information:   Project website 

Title: EuroPathoGenomics: a Network of Excellence to Strengthen Genome Research on Pathogenic Microorganisms
Acronym:   EPG
Project summary:   The genomes of pathogenic bacteria offer clues about how to combat these microbes. To promote European research into this area, the European Union supports the Network of Excellence “EuroPathoGenomics” with 6.7 million Euro. This project, comprising 37 top-level laboratories from 13 different nations, is co-ordinated by the University of Würzburg under the direction of Professor Jörg Hacker. There is an urgent need for research in the field of infection diseases. The WHO estimates that diseases caused by bacteria or viruses are responsible for one-third of all deaths world-wide. Furthermore, many pathogens become increasingly resistant to available drugs and antibiotics. Up to now, the complete genomes of about 200 pathogenic microbes have been sequenced, and further sequencing projects are in progress throughout the world. Scientists hope to gain additional knowledge and insights into the processes by which microbes cause diseases. Innovations in diagnostic techniques and therapy, as well as the development of vaccines, are expected to come out of the research network. One of the major objectives of the network “EuroPathoGenomics” is to structure and organise the overwhelming mass of data coming out of genome research into microorganisms and their corresponding hosts. The aim is to detect interactions between host cells and both pathogenic and harmless microbes. The network brings together existing initiatives that investigate genomes of pathogenic microorganisms. The German network of expertise “PathoGenoMik”, which is located at the University of Würzburg, is integrated into “EuroPathoGenomics”, as well as the research networks “Génopole” and “Pathopole” in France, MICMAN in Sweden and Finland, and “Genau” in Austria. Another focus of the project is the establishment of the “EuroPathoGenomics Graduate Academy”. This virtual network brings together existing European graduate colleges. It provides young scientists a broad-based interdisciplinary study programme with a wide range of seminars, lectures, and practical workshops. It is hoped that the Graduate Academy will not only train young scientists but will enhance the exchange of knowledge between them, and improve communication within the network and the dissemination of expertise.

Additional project information:   Project website 

Title: Reprogramming the immune System for the Establishment of Tolerance
Acronym:   RISET
Project summary:   Transplantation dramatically improves the survival of patients with end-stage failure of vital organs. However, as a direct consequence of the immunosuppressive drugs permanently required to prevent rejection, recipients have a significantly increased risk of infection and malignancies Moreover, these drugs are expensive, do not prevent long-term damage of the graft, and exert toxic effects outside the immune system. The induction of transplant tolerance, defined as permanent acceptance of the graft in absence of continuous immunosuppression, would be a major step forward Recent advances in post-genomic immunology suggest that this goal is achievable in a near future. Indeed, new biotechnology products have been shown to promote long-term transplant acceptance in pre-clinical models. RISET will focus on the translation of these advances into industrial development and clinical practice First, diagnostic tests to identify transplanted patients for whom immunosuppressive treatment could be safely minimized or withdrawn will be developed. These tests will be applied to patients under conventional treatment as well as to patients enrolled in pilot clinical investigations based on cellular products with potential for tolerance induction. Because of the nature of this research, effective communication with patient organizations and regulatory bodies will be organized, and related ethical and societal questions will be specifically addressed. In parallel, relevant models of tolerance will be used to identify new genes, molecules or cell types that will form the basis for novel diagnostics and therapeutic approaches. The exploitation of the knowledge created in RISET will be facilitated by the inclusion of several SMEs in the consortium and the creation of an industrial platform. In order to exploit innovative concepts emerging outside the consortium, RISET will be open to new industrial or academic partners for which a budget has been provisioned.

Additional project information:   Project website 

Title: Curing autoimmune disease. A translational approcah to autoimmune diseases in the post-genomic era using inflammatory arthritis and myositis as prototypes and learning examples.
Acronym:   AUTOCURE
Project summary:   Objective: To transform knowledge obtained from molecular research particularly within genomics, into a cure in an increasing number of patients suffering from inflammatory rheumatic diseases. Rheumatoid arthritis (RA) is used as a prototype since this disease offers unique opportunities to define and evaluate new therapies. State of the art and beyond: Development of the first generation of targeted therapies (anti-TNF and anti-IL-1) in chronic inflammatory disease used RA as the prototype disease after work from European investigators included in the current IP. This work demonstrated (i) that targeted therapies can be efficient and (ii) that cure is still not achieved, but is within reach through a strong international consortium covering translational research and molecular technology. Work plan: -Potential key molecular mechanisms determining the course of RA and myositis are defined from genetic studies in humans, from relevant animal models and from basic cell and molecular biology. - Predictors of disease development and therapeutic responses, enabling future individualised therapies, are developed with the help of our unique large patient cohorts and, biobanks.. - Development and evaluation of new therapies is performed using combinations of novel molecular tools and precise definition of disease phenotypes. Impact of the project: We aim to produce (i) an increased understanding of the causes of RA and myositis enabling better prevention; (ii) new potential targets for therapy in arthritis and myositis, which can be further tested in other rheumatic inflammatory diseases; (iii) a prototype system for translational research in Europe, enabling collaborative development of targeted therapies in many inflammatory diseases and enabling European SMEs to rapidly develop ideas and patents into targeted therapies in inflammatory diseases.

Additional project information:   Project website 

Title: Genomics, mechanisms and treatment of addiction
Acronym:   GENADDICT
Project summary:   Addiction is a brain disease, common in Europe, with deleterious consequences on individual physical and psychological health, and serious societal and economic consequences through criminality and violence, decreased productivity and increased healthcare costs. In every family, in a lifetime one can identify someone who has suffered from addiction; alcohol, nicotine or illicit drug use affects many people. Over 20 years there has been little advance in the drug treatment for addiction, with most new treatments addressing physical drug withdrawal rather than treating drug craving and relapse. The contribution of genetic influences to addiction liability has been recently recognised but the identification of genetic risk factors and genes involved in the molecular basis of addiction is a new major challenge for the post-genomic era. This project is a collaboration between basic science groups, one SME and a leading biotechnology company devoted to human studies on the role of genes in complex diseases. This public-private partnership brings together a highly innovative genealogical led human genetics approach and a team of researchers with Europe¹s best genomic mouse models. The core of the research effort will be the identification of genes associated with drug addiction using an unbiased genome-wide approach. The strong environmental component in the etiology of drug addiction has presented a particularly difficult problem for genetic studies of this brain disorder in the past. The groups of this Consortium propose to meet this difficult challenge by combining powerful animal genetics and gene profiling strategies with a human genetic approach that is relatively resistant to environmental modifications of the drug addiction phenotype. Genes identified in this project will help to elucidate dysfunction of genetic pathways in the addicted brain and provide new targets for the development of novel therapies.

This integrated project started on 1 January 2005, and lasts 60 months. It involves 8 participants from 7 EU countries.

Additional project information:   Project website 

Nanotechnologies and nanoscience, knowledge-based multifunctional materials, and new production processes and devices
Title: Cell Programming by Nanoscaled Devices
Acronym:   CellPROM
Project summary:   The vision of the IP is to develop an automated device for the imprinting of cells via nanoscaled macromolecular landscapes, the NanoScapes. This will allow, for the first time, to non-invasively produce well-defined populations of individually programmed cells, eventually leading to substantial breakthroughs and numerous applications in the fields of molecular medicine and cellular nano-biotechnology (36 partners).
Additional project information:   Project website  CORDIS News article  Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Integration of manufacturing systems for Mass-Manufacture of miniature/micro-products
Acronym:   MASMICRO
Project summary:   The overall objective of the project is to develop an integrated solution for European miniature/micro- manufacturing and related industries - an integrated manufacturing facility for mass manufacture of miniature/micro-products, and a technology transfer/training package for transforming EU Industries (36 partners).
Title: Carbon Nanotubes for Applications in Electronics, Catalysis, Composites and Nano-Biology
Acronym:   CANAPE
Project summary:   A major limitation on the application of the unique properties of carbon nanotubes has been their high cost and lack of availability. This IP brings together leading laboratories and companies within Europe to produce nanotubes on a bulk scale of ultimately tons per year. The large scale growth of carbon nanotubes will be developed by chemical vapour deposition (CVD) (15 partners).
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Emerging Nanopatterning Methods
Acronym:   NaPa
Project summary:   The Emerging Nanopatterning Methods (NaPa) consortium integrates the new patterning methods into one project, both anticipating and responding to the increasing need for technologies, standards and metrology required to harness the new application-relevant properties of engineered structures with nm-scale features. NaPa brings together 35 leading academic and industrial European institutions with a vast amount of recent know-how on nanofabrication, partly developed within FP5 (35 partners).
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Advanced Interactive Materials by Design
Acronym:   AIMS
Project summary:   Urgent needs for better production technologies arise from current development of new pharmaceutical products like fermentation-based antibodies, recombinant proteins or monoclonal antibodies (MABs). (28 partners)
Title: New Materials for Extreme Environments
Acronym:   ExtreMat-IP
Project summary:   The goal of this Integrated Project is to provide and to industrialize knowledge-based materials and their compounds for top-end and new applications in extreme environments that are beyond reach with incremental materials development only (38 partners).
Title: Innovation and Sustainable Development in the Fibre Based Packaging Value Chain
Project summary:   The overall objective of the RTD activities is to develop and implement a Sustainable Packaging Tool Platform based on renewable resources, giving innovative properties to packaging, thereby offering new value added packaging options for packaging users and for consumers. The project is expected to result in new innovative renewable packaging materials with improved material characteristics (36 partners).
Title: Biotechnology for metal bearing materials
Acronym:   BIOMETECH
Project summary:   This IP is aimed at developing sustainable solutions covering the whole life cycle of products and equipment. The Project will adopt a multi-discipline approach involving mining companies, waste treatment facilitators and equipment/instrument suppliers. The Consortium has achieved a critical mass being comprised of 44 partners from industry (18 including 9 SMEs), research organisations (8), universities (16) and government (2) (45 partners).
Title: New and innovative processes for radical changes of the European pulp and paper industry
Acronym:   ECOTARGET
Project summary:   The overall objective of ECOTARGET is to enhance the competitiveness of the pulp and paper sector (including its suppliers) of Europe while at the same time improving the eco-efficiency. The partnership involves leading industrial companies producing pulp and paper as well as companies supplying this industry with machinery, chemicals etc. The partnership also involves the major European research institutes and leading universities active in fields of relevance (31 partners).
Title: NAnoscale Integrated processing of self-organizing Multifunctional Organic Materials
Acronym:   NAIMO
Project summary:   NAIMO will develop new multifunctional materials that are processed by solution-based additive manufacturing (e.g. direct printing), under quasi-ambient conditions, so that a set of materials can be added onto a wide range of structural substrates, to form a composite material with designed multifunctionality in an environmentally friendly way. As well as a broad partnership which includes Academic institutions and Industry and Industrial associates there is also a group of industrial associates that support the project without actively participating (23 partners).
Additional project information:   Project website  CORDIS News article  Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: A Systems Approach to Tissue Engineering Processes and Products
Acronym:   STEPS
Project summary:   STEPS introduces a breakthrough strategy that addresses a new systems approach to TE and associated technologies. It is the clear objective of STEPS to provide a totally new infrastructure, based upon the hypothesis that the only way to create successful commercialisation and clinical implementation of TE is to systematically take all aspects of this multidisciplinary process and apply the logistics of systems engineering to link them together (25 partners).
Additional project information:   Liverpool leads new European tissue engineering project 
Title: Intermetallic Materials Processing in Relation to Earth and Space Solidification
Acronym:   IMPRESS
Project summary:   The scientific objective of the IMPRESS Integrated Project is to understand the critical link between materials processing, structure and final properties of novel, higher-performance inter-metallic alloys. These multifunctional materials possess remarkable mechanical, physical and chemical properties, which make them very attractive for certain extreme applications. Activities such as education, training and technology transfer will also be firmly embedded into the RTD programme (45 partners).
Title: Novel and improved nanomaterials, chemistries and apparatus for nanobiotechnology
Acronym:   NACBO
Project summary:   This IP proposes the research, development and commercialisation of discrete but overlapping areas of material science, materials chemistry and supporting/applying hardware systems. It will deliver novel and improved solutions to emerging and current needs in biology, health, chemistry, process engineering and the environment. Most particularly its outputs intend to address molecular diagnostics (13 partners)
Title: Intelligent Materials for Active Noise Reduction
Acronym:   InMAR
Project summary:   The objective of the proposed Integrated Project "Intelligent Materials for Active Noise Reduction (InMAR)" is therefore the realization of intelligent, high performing adaptive material systems with integrated electronics able to be applied for noise mitigation purposes, even in highly loaded structures as construction material in the same manner as common passive or light weight materials are used (42 partners).
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.

Title: Integration of technologies in support of a passenger and environmentally friendly helicopter.
Project summary:   Today's helicopters need to be improved further with respect to environmental and public acceptance. Helicopters generate external noise, cabin noise and vibration due to the complex nature of their dynamic systems and suffer from NOx emission; like other transport systems. It is therefore very essential that the new generation rotorcraft adress these issues to improve the situation, to make them environmentally friendly and acceptable to the general public. The modern society needs this indispensable system due to its ability to fly medical, rescue and law enforcement missions. These missions require flight profiles close to populated areas. Hence, a number of enhancements appears mandatory. In detail, the following goals are envisaged:
  • External noise levels 10 db below the current ICAO/JAA rules especially during approach,
  • A reduction of fuel consumption up to 20 % for high speed flights.
  • Cabin noise levels below 70 dBA similar to airliner cabins for normal cruise flight,
  • Cabin vibrations below 0,05 g corresponding to jet smooth ride comfort for the same flight regime.
Because of the large and fast rotating rotor, the non-symmetric rotor flow, the close vicinity of main gearbox and passenger position and the specific requests of engine performance, the targets mentioned above are highly challenging. In order to comply with the research objectives, an extreme high tech initiative is required, enabling however European aeronautic industry to hold their own against international competitors. In order to do so, short and long term objectives are planned targeting the following technology topics:
  • Short Term objectives: Noise Abatement Flight Procedures, Cabin Noise Reduction Engine Noise Reduction
  • Long Term Objectives: Active Blade Control
The activities envisaged in Friendcopter are to provide a number of key deliverables. All of these will have undergone intense efficiency testing, mostly by flight tests. In detail, they will consist of:
  • Low noise flight procedures especially for approach as guidelines for pilots,
  • A technology of noise absorbing engine inlets and outlets;
  • Methods to identify noise leaks in cabin & systems to actively and passively reduce cabin noise;
  • A control technology to reduce rotor noise, vibration excitation, and fuel consumption by distributed actuation along the blade surface;
  • A Mach-scaled wind tunnel model rotor ready for wind tunnel tests.

Additional project information:   CORDIS News article 
Title: Optimized Procedures and Techniques for IMprovement of Approach and Landing
Acronym:   OPTIMAL
Project summary:   As traffic grows steadily, airport congestion and environmental impacts become a mounting problem and already a limiting factor at some airports. OPTIMAL is an air-ground co-operative project which is aiming to define and validate innovative procedures for the approach and landing phases of aircraft and rotorcraft in a pre-operational environment. The goal is to minimise external aircraft/rotorcraft noise nuisance and increase the ATM capacity while maintaining and even improving safety. Those achievements will be enabled by new precision approach landing aids (MLS, SBAS, GBAS), more accurate navigation means (RNP 0.1) and enhanced airborne systems, such as FLS, for Non-Precision Approaches. The target time frame for the operational implementation of the OPTIMAL proposed operational concept is 2010 and beyond, it will therefore participate in reaching the targets for airport capacity developments identified in the ATM 2000+ Strategy and in the ACARE Strategic Agenda.The work to be conducted during the 4 years project is ranging from the elaboration of the operational concept up to simulations and pre-operational flight trials implying effective modifications of avionics onboard aircraft and rotorcraft and ground systems. On the ground system side special attention will be placed on the new tools which will be necessary for Air Traffic Controller to efficiently and safely manage the OPTIMAL procedures.The OPTIMAL project team is composed, among others, by the major european aircraft, rotorcraft and airborne & ground systems manufacturers, major european research institutes, various ATS providers, and key experts in procedures specification and validation exercise. This team quite early identified the key methods and tools to manage adequately all work-packages of the project. Particular emphasis is made on the project management organisation, the methodology to define the procedures, the validation methodology.

Additional project information:   Project website 

Title: Technologies and Techniques for New Maintenance Concepts
Acronym:   TATEM
Project summary:   Maintenance activities can account for as much as 20% of an operator's direct operating costs and have remained at this level for many years. However, there is scope for increasing the efficiency of the maintenance process. For example, it is estimated that line mechanics spend 30% of their time trying to access information to diagnose and rectify failures. Additionally errors in the maintenance process can impact on aircraft safety. In a recent survey the incidence of human error in the maintenance task has been estimated as contributing to 15% of aircraft accidents. The occurrence of the need for unscheduled maintenance can introduce costly delays and cancellations if the problem cannot be rectified in a timely manner. The objective of the TATEM Integrated Project is to validate technologies and techniques which can be used to transfer unscheduled maintenance to scheduled maintenance and provide the means to make the maintenance task more efficient and effective.The technologies and techniques to be validated include: Novel onboard sensor technology to gather data from the aircraft systems (avionics, utilities, actuation, engines and structures), Maintenance-free avionics,Signal processing techniques (e.g. fuzzy, logic, neural networks, model-based reasoning) which can be used to convert data into information about the health of the systems.Diagnostic methods to identify and locate failures and malfunctions and so reduce the number of incidences of no fault found, Prognostic methods to provide support for preventative maintenance actions Decision support techniques to provide the maintenance crew with process-oriented information and guidance, Human interface technologies to provide the ground crew with information at their point of work.
Title: Value Improvement through a Virtual Aeronautical Collaborative Enterprise
Acronym:   VIVACE
Project summary:   VIVACE is a project set-up in the framework of AECMA addressing aeronautics' Vision 2020 objectives to contribute significantly to fulfilling 3 specific targets of the aeronautics industry Strategic Research Agenda:
  1. Halve the time to market for new products with the help of advanced electronic analytical, design, manufacturing and maintenance process, methods & tools
  2. Increase the integration of the supply chain into the network
  3. Maintain a steady and continuous fall in travel charges through substantial cuts in operating costs.
VIVACE will develop advanced capabilities (Knowledge Enabled Engineering, Multidisciplinary Design and Optimisation, Design to Decision Objectives, Engineering Data Management, Distributed Information Systems Infrastructure for Large Enterprise and Collaborative Hub for Heterogeneous Enterprises) applied on real case engineering and business scenarios from the aircraft and engine sectors. The main result of VIVACE will be an Aeronautical Collaborative Design Environment and associated Processes, Models and Methods to design an aircraft and its engines as a whole, providing to the aeronautics supply chain in an extended enterprise, virtual products with all requested functionality and components in each phase of the product engineering life cycle. VIVACE will make its approach available to the aeronautics supply chain via existing networks, information dissemination, training and technology transfer actions. It will last 4 years and be organised into 3 technical sub projects dealing with the Aircraft, the Engine and Advanced Capabilities that will federate all developments. A fourth sub project will take care of management and innovation issues. VIVACE will start from past experiences and results gained in concurrent Engineering such as ENHANCE and will bring together 55 partners from industry, research institutes, universities and technology providers.
Title: Security of Aircraft in the Future European Environment
Acronym:   SAFEE
Project summary:   SAFEE is a large integrated project designed to restore full confidence in the air transport industry. The overall vision for SAFEE is the construction of an advanced aircraft security system designed to operate during on-board terrorist threat scenarios. The main goal of this system is to insure a full secure flight from departure to arrival destination whatever the identified threats. The project's baseline is the assumption that upstream identification control and airport specific security measures have all been completed. The project is focussed on the implementation of a wide spectrum of threat sensing systems, and the corresponding response actions against physical person(s) or electronic intruders. One of the key aspects of the project is an integrated information management system underpinned by a secure communication system. For reaching these objectives SAFEE has 5 key activities named subprojects (SP):
SP1: Onboard threat detection: a large spectrum of various threats detection system is proposed
SP2: Threat Assessment and Response Management System: a urgency decision making tool
SP3: Flight reconfiguration includes an Emergency Avoidance System and an automatic guidance system to control the aircraft for a safe return
SP4: Data protection system securing all the data exchanges (in and out the aircraft).
SP5: Innovation activities, dissemination, economics, exploitation, legal and regulatory issues about citizen's privacy and rights. The proponents are major European industrial actors of the Aeronautical sector associated with a high level research centre, several relevant SMEs and specialised universities.

Additional project information:   Europa news article 
Title: Services, integrating EO monitoring capacities, to support the implementation of European directives and policies related to "land cover and vegetation"
Acronym:   GEOLAND
Project summary:   Geoland combines 56 European service providers, research institutions, and user organisations. geoland organises the broad range of "land applications" addressed by European Directives and Policies into eight sub-projects offering a comprehensive portfolio of 61 products and services to be demonstrated and validated on 16 representative European and international testsites with 31 key user organisations. geoland observatories are providing products and services addressing regional monitoring and reporting for nature protection, water and soil issues, spatial planning, and strategic information on food security and crop monitoring, global land cover and forest change, and natural carbon fluxes. geoland is supported by a unique group of European and international organisations with a legal mandate for policy making, establishing standards and implementing policies and directives through monitoring and reporting. These users are directly involved in the product development and validation process either as members of the consortium or as associated partners committed to locally test the products and services. geoland is efficiently managed by setting a flexible framework for all partners sharing common product development and quality standards, and common intermediate products between all sub-projects. Partners targeting the same application segment are horizontally integrated; they joint develop the product portfolio on core test sites, share common value chains as far as possible, and systematically roll out to all European regions resp. global test sites. geoland supports the observatories and core services implementation with a joint "operational scenario" team analysing service infrastructure and GMES operational implementation models following an open service concept; a support team provides all partners with specific project management, strategic analysis, and communication and professional training support.
Title: Marine Environment and security for the European Area
Acronym:   MERSEA
Project summary:   MERSEA aims to develop a European system for operational monitoring and forecasting on global and regional scales of the ocean physics, biogeochemistry and ecosystems. The prediction time scales of interest extend from days to months. This integrated system will be the Ocean component of the future GMES system. At the core of the system is the collection, validation and assimilation of remote sensed and in situ data into ocean circulation models that allow for the self consistent merging of the data types, interpolation in time and space for uniform coverage, nowcasting (i.e. data synthesis in real-time), forecasting, and hindcasting, and delivery of information products. The project will develop Marine Applications addressing the needs of both intermediate and end-users, whether institutional or from the private sector, with the objective to improve the safety and efficiency of maritime transport and naval operations; to enable the sustainable exploitation and management of ocean resources (offshore oil and gas industry, fisheries); to more efficiently mitigate the effects of environmental hazards and pollution crisis (oil spills, harmful algal blooms); to improve contribution to ocean climate variability studies and seasonal climate prediction and its effects on coastal populations; to improve national security and reduce public health risks; and to advance marine research with the aim to better understand the global climate, the ocean and its ecosystems. The project will lead to a single high-resolution global ocean forecasting system shared by European partners together with a coordinated network of regional systems for European waters which will provide the platform required for coastal forecasting systems. During the project the main preoperational systems will be transitioned towards operational status and three of the centres will converge on a single ocean model framework suitable for both the deep ocean and shelf-seas.
Title: Terrestrial Wireless Infrastructure integrated with Satellite Telecommunications for E-Rural.
Acronym:   TWISTER
Project summary:   The objective of the TWISTER Integrated Project is to support the development and widespread adoption of satellite communication services to deliver broadband services for rural areas. TWISTER will provide innovative applications meeting the specific needs of various rural user communities such as local administrations, educational institutions, health care practitioners, SMEs and agricultural communities. Concrete applications such as data transfer and videoconferencing between islands in Malta or Greece, high data rate Internet access for villages in Spain or France, e-business development for SMEs in rural regions of Poland will be tested on various sites (35 sites deployed in the first 18 months and up to 350 ultimately), selected with the support of national and regional public authorities. User satisfaction (quality of service) will be evaluated to propose improvement and to specify a roadmap for further services deployment. The integration of space-based infrastructure with terrestrial systems, aims at achieving a seamless broadband coverage in rural areas. TWISTER will investigate a number of hybrid satellite-wireless architectures (with adaptations of security or billing schemes) and validate their on-site performances. To promote the use of satellite services, the project will foster the adoption of the DVB-RCS open standard. TWISTER will complement ESA and Satlabs group activities by validating the performance of low cost interoperable DVB-RCS terminals at end-to-end application level in a real operational environment. Being able to offer simultaneous services over large areas, the space-based infrastructures will favour the enlargement of the European Union. TWISTER will involve partners and user communities from the new entrants (Poland, Malta, Latvia), current EU member states (France, Greece, Spain, The Netherlands, Sweden) and countries associated with the FP6 programme (Norway, Canada). The TWISTER Consortium, involving all actors in the Telecom Value Chain, like User Communities, Service Provider, Satellite Operator or Equipment Manufacturers, under Astrium coordination, will create the necessary conditions to successfully deploy all over European rural regions such satellite solutions as a complement to terrestrial means, for the benefit of the population and the economy.
Additional project information:   Europa news article 

Title: Improving quality and safety and reduction of costs in the European organic and low input supply chain.
Project summary:   This Integrated Project (33 participants) aims to lead to new technologies and systems for organic and low input production systems. One of its strengths is a matrix structure whereby the research will encompass the whole food chain from fork to farm for a number of sectors including protected crops (tomato), field vegetables (lettuce), fruit (apple), cereal (wheat), pork, dairy and poultry. It addresses consumer attitudes and expectations, impact of organic foods on nutritional, sensory, microbiological and toxicological quality/safety of foods, development of new technologies and identification of socio-economic, environmental and sustainability impacts of innovations. This project has the scientific rigour to provide the meaningful information that is lacking on the extent to which differences in production systems affect nutritional value, taste and safety of food. It is expected to make a significant impact on increasing the competitiveness of the organic industry in a number of sectors to the benefit of the European consumers
Additional project information:   Project website  CORDIS News article 
Title: Health improving, safe seafood of high quality in a consumer driven fork-to-farm concept
Project summary:   This Integrated Project (80 participants) aims to reduce health problems and to increase well-being among European consumers by applying the benefits obtained through consumption of health promoting and safe seafood products of high eating quality. The relevance of seafood in the diet to diminish the higher incidences of cardiovascular, cancer and inflammatory diseases for instance will be assessed by performing dietary intervention and epidemiological studies. Seafood's importance for consumer well-being and behaviour will be assessed to understand determinants of consumers' seafood consumption and to adapt seafood products to consumer demands. The objectives of the seafood safety component are to make seafood safe for the consumer, by identifying risk factors and to undertake risk-benefit analysis. Validated traceability systems will be assessed to make it possible to apply a total chain approach from the live fish to the consumer product, and to trace back any feature from fork-to-farm.
Additional project information:   Project website  Europa news article 
Title: Diet, genomics and the metabolic syndrome: An integrated nutrition, agro-food, social and economic analysis
Acronym:   LipGene
Project summary:   The focus of this Integrated Project (24 participants) is the interaction between dietary fat composition and genotype in the metabolic syndrome. This disorder is associated with overweight and obesity and is characterised by insulin resistance, dyslipidaemia and hypertension. Access to a large prospective cohort, together with clinical and nutritional data, provides a unique opportunity to determine diet-gene interaction in the development of the metabolic syndrome. A large multi-centre dietary intervention study will examine responsiveness to dietary fat modification, varying in both fat content and composition, influence insulin sensitivity and other aspects of the metabolic syndrome. A key aim of the project is to improve the fat composition of milk and meat products (animal nutrition) and to provide novel sources of fatty acids (plant biotechnology). An economic analysis of the costs associated to the metabolic syndrome will be undertaken, while consumer attitudes will be analysed.
Additional project information:   Project website  Europa news article  CORDIS News article 
Title: Promoting food safety through a new integrated risk analysis approach for foods
Acronym:   SAFE FOODS
Project summary:   This Integrated Project addresses the issue of how consumer confidence in consumer protection and risk analysis can be restored and strengthened. The proposed research attempts to improve current risk analysis practices for foods produced by different breeding approaches and production practices deploying high and low input systems. The research activities will result in designing new effective procedures for risk analysis underpinned by new scientific assessment methods, and embedded in a broad impact analysis of social, financial and economic consequences, and with high levels of transparency, active public engagement and improved risk communication.
Additional project information:   Project website  Commission News Alert 
Title: Integration of animal welfare in the food quality chain: From public concern to improved welfare and transparent quality
Project summary:   This Integrated Project (39 participants) addresses these objectives and, importantly, pays particular attention to the "fork-to-farm" approach through establishing a strong society-science dialogue. In this context, appropriate and robust on-farm welfare assessment methodologies will be developed together with information frameworks and an array of targeted, high priority welfare improvements. The proposal bring together many important European players in a well-structured project that offers a real possibility for Europe to cement its position as a leader in farm animal welfare research..
Additional project information:   Project website  Commission News Alert 
Title: New strategies to improve grain legumes for food and feed
Project summary:   This Integrated Project (66 participants) will mobilise and integrate European scientific research on grain legumes by addressing the following objectives; i) to identify optimal parameters for legumes in feed and food quality and safety, including GMOs, while using legumes to develop healthy and sustainable agriculture, ii) to investigate variation in grain legume seed composition and the factors affecting it, iii) to develop new genetic, genomic, post-genomic and bioinformatic tools to improve and sustain grain legume seed production and quality. To achieve objectives the project will integrate an ambitious combination of approaches, including biochemistry, plant & crop physiology, agronomy, plant genomics & breeding, and human nutrition & health studies. Particular emphasis will be placed upon the use of state-of-the-art methodologies including genomics and bioinformatics, together with transcriptomics and metabolomics.
Additional project information:   Project website 
Title: The Prevalence, Cost and Basis of Food Allergy Across Europe
Project summary:   This four-year integrated project, will investigate the patterns and prevalence of food allergies throughout Europe, by surveying a large number of newborn children in five centres, and cross-sectional groups of adults and children in at least nine and possibly ten other centres. It involves over fifty food, medical and agricultural research organisations throughout the EU, including some from new Member States. The project is looking for new biochemical or genetic predictive markers for allergies. EUROPEVALL is investigating better tests to replace challenge tests in which sufferers or samples of their tissue are exposed to allergenic material. The candidate tests are serological, using purified food allergens and novel detection with peptide or protein chips, as well as more conventional methods. Detection will also depend on a library of well-analysed allergens, ranked according to the severity of the reactions they induce. The new tests will improve diagnosis and reduce the impact of allergies.
Additional project information:   Project website 
Title: Improved immunity of aquacultured animals
Acronym:   IMAQUANIM
Project summary:   Based on important disease models, this project concerns development of a technological knowledge platform for a future improved immunity to infectious pathogens in the major aquacultured species in Europe (Atlantic salmon, rainbow trout, sea bream, sea bass, carp, mussel and oyster). Focus will be put on use of vaccines, immuno-stimulants, immuno-diagnostic surveillance as well as markers for selection of the most immuno-competent individuals. Assays for qualitative and quantitative monitoring of key elements of the innate and adaptive immune system at genetic and functional levels will be established and used for determination of response profiles which correlate with protective immunity. IMAQUANIM'S data will provide a strong technological basis for qualified strategies to counteract rapidly known or new diseases in aquacultured fish. The resulting gene arrays and immune-response assays will be employed to develop efficient vaccines and feed-based immuno-stimulants for finfish species.
Title: Exploitation of natural plant biodiversity for the pesticide-free production of food
Project summary:   The aim of this project is to force a break-through in breeding for resistance to fungal pathogens using genomics and post-genomics tools to exploit natural host plant resistance. Two strategies will be followed to design new resistant varieties: i) marker-assisted breeding and ii) genetic engineering. Selecting plants at the seedling stage using molecular markers shortens the time considerably between the first cross involving wild species and introduction on the market. A major goal of this project is to exploit these genetic resources for breeding resistant varieties, either made with or without genetic engineering. The relative importance of GM techniques for the SMEs to develop new varieties for the regular market in this project is difficult to predict. This Integrated Project will focus on wheat and potato - the two most important staple crops for all consumers in the EU - for which pesticides, mainly fungicides.
Title: Control and prevention of emerging and future pathogens at cellular and molecular level throughout the food chain
Project summary:   Food safety is of fundamental importance to the European consumer, food industry and economy. The impact on trade and competitiveness is very substantial. Despite significant investment the incidence of food derived disease still increases in the EU. PathogenCombat attacks this pan-European problem through a holistic, multidisciplinary approach towards threats from new/emerging pathogens in the entire food chain. A number of advanced platforms will be developed to investigate the survival and virulence expression of pathogens in feed and food, and on contact surfaces in the food chain including the intestinal tract of farm animals. The platforms, of which several are used for the first time in food safety studies, comprise bioimaging, laser tweezers, phage display/convergent evolution, functional mammalian cell models, functional genomics and microarrays. New/emerging food borne bacteria, yeast, filamentous fungi and viruses are targeted for milk and dairy products, poultry and pigs and their meat products.
Title: Diet, Obesity and Genes
Acronym:   DIOGENES
Project summary:   The rapid growth in the prevalence of obesity and associated co-morbidities, in particular the rise in childhood obesity across Europe are major global health concerns. Susceptibility to obesity is determined largely by genetic factors but the current epidemic is significantly influenced by lifestyle factors. DiOGenes aims to contribute to a better understanding of the disease and its alleviation by dietary means by including all disciplines and stakeholders. To examine critically the dietary impact, an 8-country, long-term randomised, parallel dietary intervention study on whole families will take place. Food technology studies will seek to develop food combining high consumer liking/preference with enhanced satiety signals to limit intake.
Additional project information:   Project website 
Title: EaRly Nutrition programming- long term Efficacy and Safety Trials and integrated epidemiological, genetic, animal, consumer and economic research.
Acronym:   EARNEST
Project summary:   Recent data indicate that the connection between perinatal nutrition and adult health is significant and measurable. The five-year EARNEST project will collect the best possible data from large randomised, controlled human trials and prospective studies to examine the mechanisms by which early nutrition programmes long-term adult health. EARNEST will assess the socio-economic costs of poor nutrition and analyse consumer knowledge and attitudes about nutritional programming. It will establish the potential of public health interventions to prevent and reverse harmful programming. It will also provide quantitative estimates of how European wealth creation would be enhanced by improved early nutrition. The resulting data from all these studies will furnish a strong scientific basis for promoting health in European populations, helping to correct social inequalities in healthcare, education and policy development.
Additional project information:   Project website 
Title: Exploiting bioactivity of European cereal grains for improved nutrition and health benefits
Project summary:   The HEALTHGRAIN Integrated Project aims to improve the well-being and reduce the risk of metabolic syndrome related diseases in Europe by increasing the intake of protective compounds in whole grains or their fractions. The aim is to produce health promoting and safe cereal foods and ingredients of high eating quality. A whole grain diet is increasingly demonstrated to be protective against development of diet related disorders such as cardiovascular disease and type 2 diabetes. HEALTHGRAIN will carry out an integrated, multidisciplinary effort to establish the variation, process-induced changes and human metabolism of bioactive compounds in the major European bread grains, and to reveal the physiological mechanisms underlying their significance in prevention of metabolic syndrome and related diseases.
Additional project information:   Project website 
Title: GM and non-GM supply chains : their CO-EXistence and TRAceability
Acronym:   CO-EXTRA
Project summary:   The objective of Co-Extra is to provide all the stakeholders of the food and feed chains with a central decision-support system integrating the tools, methods, models and guidelines needed to deal with the imminent arrival of large quantities of GMOs, further to the lift of the current de facto ban on GMOs in the EU. Co-Extra will study and validate biological containment methods and model supply chain organisations and provide practical tools and methods for implementing co-existence. In parallel, Co-Extra will design and integrate GMO detection tools, develop sampling plans, and elaborate new techniques to meet the challenges raised by stacked genes and as yet unapproved or unexamined GMOs. Co-Extra will also study and propose the most appropriate information structure, content and flow management for ensuring reliable and cost-effective documentary traceability. Co-Extra outcomes will contribute to reinforcing consumers confidence in labelling claims and therefore EU products at large.
Additional project information:   Project website 
Title: New Technologies to Screen Multiple Chemical Contaminants in Foods
Acronym:   BIOCOP
Project summary:   Chemical contaminant monitoring in foodstuffs is a highly important and complex issue. A huge investment in time and effort is placed on these activities by regulatory and industrial laboratories. The Biocop proposal has been constructed to supply regulators, consumers and industry with long-term solutions to the complex problems associated with chemical contaminants. A range of new technologies such as transcriptomics, proteomics and biosensors will be utilised within the project. These new approaches are based on measuring effect rather than on measuring single target compound concentrations. The biomarker and fingerprinting concept is key to this strategy. Experts from all classes of chemical contaminants will oversee the project to ensure fit-for-purpose tests are developed and validated to the required standards.
Additional project information:   Project website 
Title: Tracing Food Commodities in Europe
Acronym:   TRACE
Project summary:   TRACE will develop generic and commodity specific traceability systems that will enable the objective verification of the origin of food and animal feed. Natural tracers such as trace elements, ratios of heavy (geo) and light (bio) isotopes and genetic markers will be measured to determine geographical, species and production origin. Geo and bioclimatic mapping will be undertaken to extrapolate geographical origin and reduce the need for commodity specific data bases. The project will focus on meat, cereals, honey, olive oil and mineral water. TRACE will develop and draft standardised XML 'request-response' schemes for coding and electronic information exchange and establish Good Traceability Practice .
Additional project information:   Project website 

Title: A new PV wave making more efficient use of the solar spectrum
Project summary:   Fundamental and applied scientific research into a whole new generation of PV cells making use of the full spectrum of solar radiation through four new research paths promising a step change in efficiency up to 40% and correspondingly lower costs
Title: Clean Hydrogen-rich Synthesis Gas
Acronym:   CHRISGAS
Project summary:   This project is of vital interest to the transport sector as it will develop and optimise an energy- and cost-efficient method using all the carbon content to produce hydrogen-rich gases from biomass, including residues. The hub of the project will be the Värnamo Biomass Gasification Centre pilot facility in Sweden.
Title: CO2 - from Capture to Storage
Acronym:   CASTOR
Project summary:   CASTOR is an integrated project which addresses capture and storage of CO2 associated with cleaner fossil fuel plants. The overall goal of this IP is develop and validate, in public/private partnerships, all of the innovative technologies needed to capture, at the post combustion stage, transport and store CO2. The target is to enable the capture and geological storage of 10% of the CO2 emissions of Europe which corresponds to about 30% of CO2 emitted by European power and industrial plants.
Title: Crystalline Silicon PV: Low-cost, highly efficient and reliable modules
Project summary:   Research into innovative processes and automation of manufacturing of Crystalline Si PV modules on a large scale with up to 30% higher efficiency and correspondingly reduced costs to reach a competitive level in the longer term
Title: Development of a harmonised "European Hydrogen Energy Roadmap" by a balanced group of partners from industry, European regions and technical and socio-economic scenario and modelling experts
Acronym:   HyWays
Project summary:   HyWays is an integrated project to develop the European Hydrogen Energy Roadmap. It will comprise a comparative analysis of regional hydrogen supply options and energy scenarios, including renewable energies. An integrated toolbox of proven simulation models including E3 database, MARKAL, ISIS, GEM-E3 and COPERT III will investigate technical, socio-economic and emission challenges and impacts of realistic hydrogen supply paths under consideration of technological and economical needs.
Title: Enhanced Capture of CO2
Acronym:   ENCAP
Project summary:   ENCAP is an integrated project whose objective is to develop new pre-combustion CO2 capture technologies and processes for power generation. It aims at technologies which meet a target of at least a 90% CO2 capture rate and a reduction in the cost of capture of 50% compared to present. The results from ENCAP will enable power companies to decide to launch a new design project by 2008-2010 aimed at a large demonstration plant with the potential for wide commercial exploitation in the horizon of 2015-2020
Title: Further Improvement and System Integration of High Temperature Polymer Electrolyte Membrane Fuel Cells
Acronym:   FURIM
Project summary:   High temperature resistant polymer membrane is necessary in order to maximise the efficiency of Polymer Electrolyte Membrane Fuel Cell. Furim Integrated Project will develop a high temperature (above 150°C ) membrane and technological units including fuel cell stack, hydrocarbon reformer, after burner, and power management system. All this subunits will be integrated and tested to confirm the performance and the durability.
Title: Hydrogen Storage Systems for Automotive Application
Acronym:   STORHY
Project summary:   The integrated project STORHY aims to develop robust, safe and efficient on-board vehicle hydrogen storage systems, suitable for use in hydrogen fuelled fuel cell or internal combustion engined vehicles. Three systems are under development - compressed gaseous, cryogenic (liquid hydrogen), and metal hydrides. The aim is to develop systems that are capable of being produced at industrial scale and meet commercially viable goals for cost and energy density and durability. Achieving sufficient hydrogen storage capacity for adequate vehicle range is currently a major technology bottleneck.
Title: In-situ R&D Laboratory for Capture and Sequestration of CO2
Acronym:   CO2SINK
Project summary:   Geological storage of CO2 provides a means for the EU to significantly reduce its CO2 emissions over the next decades. To address and alleviate potential public concerns about the safety and environmental impact of geological storage, a better understanding of the science of CO2 storage is needed. This integrated project aims at developing this basis by injection of CO2 into an onland saline aquifer. It involves intensive monitoring of the fate of the injected CO2 using a broad range of geophysical and geo-chemical techniques.
Title: New Energy Externalities Development for Sustainability
Acronym:   NEEDS
Project summary:   Socio-economic and energy modelling to provide decision makers with innovative tools and data to take account of externalities in analysing the real comparative costs to society of different energy forms. The research focuses on Life Cycle Assessment, internalisation of costs, transferability and generalisation.
Title: Preparing for the hydrogen economy by using the existing natural gas system as a catalyst
Acronym:   NATURALHY
Project summary:   NATURALHY will investigate the performance and safety limits for mixing hydrogen with natural gas and distributing the mix in existing local gas pipeline networks. This integrated project will consider materials and operational limitations for the pipeline systems, as well as investigate the use of hydrogen/natural gas mixes in conventional combustion applications. Membrane separation techniques will also be investigated for separating the hydrogen for example for fuelling stationary fuel cells. NATURALHY is considered to be cost-effective way to achieve near term reductions in greenhouse gas emissions, as the mixed hydrogen may be produced from renewable energy sources.
Title: Realising Reliable, Durable, Energy Efficient and Cost Effective SOFC Systems
Acronym:   REAL-SOFC
Project summary:   The aim of the REAL SOFC Integrated Project is to solve the persisting generic problems of ageing with planar Solid Oxide Fuel Cell (SOFC) in a concerted action of the European fuel cell industry and research institutions. This includes full understanding on degradation processes, finding solutions to reduce ageing and producing improved materials that will then be tested in Fuel Cell stacks.
Title: Renewable fuels for advanced power trains
Acronym:   RENEW
Project summary:   Research into innovative means of producing bio-fuel from ligno-cellulose feedstock for a range of fuel production chains for motor vehicles. These will be submitted to extensive motor-tests by 4 leading European car manufacturers
Title: The birth of a European Distributed Energy Partnership that will help the large-scale implementation of distributed energy resources in Europe
Acronym:   EU-DEEP
Project summary:   In this Integrated Project, a group of eight leading European energy utilities have joined forces to remove, in the next five years, most of the technical and non-technical barriers which prevent a massive deployment of distributed energy resources (DER) in Europe. In partnership with Manufacturers, Research Organisations, Professionals, National Agencies and a Bank (total 40 partners), they follow a demand-pull rather than technology-push approach. This new approach will provide five "fast-tracks options" to speed up the large-scale implementation of DER in Europe.

Title: Advanced protection systems
Acronym:   APROSYS
Project summary:   The IP on Advanced Protective Systems (APROSYS) will focus on scientific and technology development in the field of passive safety (crash safety). The field of passive safety concerns in particular human biomechanics (injury mechanisms and criteria), vehicle and infrastructure crashworthiness and occupant and road user protection systems. The general objective of APROSYS is the development and introduction of critical technologies that improve passive safety for all European road users in all-relevant accident types and accident severities.
Title: High efficiency engine R&D on combustion with ultra low emissions for ships
Acronym:   HERCULES
Project summary:   The HERCULES IP will develop new technologies to drastically reduce gaseous and particulate emissions from marine engines and concurrently increase engine efficiency and reliability, hence reduce specific fuel consumption, CO2 emissions and engine lifecycle costs.
Title: Assessment for future traffic demands and longer lives
Acronym:   Sustainable Bridges
Project summary:   In order to double (or even treble) the transportation by rail during the coming 20 years the capacity of the railway bridges needs to be increased. The objectives of this project are to:
  • Increase the transport capacity of existing bridges by allowing axle loads up to 33 tonnes for freight traffic with moderate speeds or for speeds up to 350 km/hour for passenger traffic with low axle loads
  • Increase the residual service lives of existing bridges with up to 25%
  • Enhance management, strengthening, and repair systems.
Much research has been carried out related to this area but there is a need for integration, innovative development and testing in order to establish procedures for the safe and effective management and upgrading of railway bridges.
Title: Hydrogen and Fuel Cell Technologies for Road Transport
Acronym:   HyTRAN
Project summary:   Two innovative Fuel Cell Systems for automotive application will be developed within specific Technological Platforms:
  • TP1 'Powertrain' development of a system for traction power by an 80 kW direct hydrogen PEM fuel cell system implemented on a passenger car
  • TP2 'APU' development of 10 kW Auxiliary Power Unit for both light-duty and heavy-duty vehicles, including micro-structured diesel oil steam reformer, cleanup reactors, an innovative reformate hydrogen stack and balance of plant components.
Title: Innovative modular vehicle concepts for an integrated European railway system
Acronym:   MODTRAIN
Project summary:   To meet the exacting performance improvements identified in the business scenarios listed in the ERRAC Strategic Rail Research Agenda as overall transport growth and transport demand increase, reliable, affordable and attractive interoperable rolling stock must become the norm for use on European networks. For this, interoperable constituents must be defined, validated and promoted at European industry level. Initially, this project will concentrate on fixed formation passenger trains and Universal Locomotives capable of 200 km/h and more, but as work advances it is hoped to extend this scope to embrace all rolling stock likely to operate over the high speed and conventional interoperable networks.
Title: Integrated collaborative design and production of cruise vessels, passenger ships and ropax
Acronym:   InterSHIP
Project summary:   The proposal aims to increase the competitiveness of EU shipbuilders by better integrating tools and methods for design and manufacturing of complex one-of-a-kind vessels. InterSHIP will enable shipyard engineers to consider leading edge knowledge in environmental aspects, safety, comfort, and cost efficiency in simultaneous engineering, thus making sure, that optimum solutions can be obtained for the total lifecycle of complex ships. InterSHIP will also focus on improving vertical integration between shipyards, owners, suppliers, classification societies and horizontal cooperation between EU shipyards. Aspects like education and training, innovation management in shipyards and cooperation with other projects and industries will be covered in horizontal actions, making sure that the project results are quickly implemented for the benefit of the entire European maritime community.
Title: New integrated combustion system for future passenger car engines
Acronym:   NICE
Project summary:   The main objective of the project is to develop a new integrated combustion system that, independently of the type of fuel (i.e. fuel neutral), is able to achieve today's highest fuel conversion efficiency of the DI diesel engine (43%), while complying with a zero-impact emission level.
Title: Optimisation of hydrogen-powered internal combustion engines
Acronym:   HYCE
Project summary:   The project examines possibilities of an efficiency enhancement of a hydrogen internal combustion engine. As a result of the project, down sized engines with a similar performance to today's fossil fuel powered vehicles would be feasible. The project is complementary to other projects in the fuel and power train cluster. In addition, there are important spin-offs possible for stationary power generation.

Title: Assessing large-scale environmental Risks with tested Methods
Acronym:   ALARM
Project summary:   The strategic objectives of ALARM are to develop an integrated large-scale assessment of the risk to bio-diversity, and terrestrial and freshwater ecosystems, including those risks arising from: climate change; environmental chemicals; biological invasions; and the loss of pollinators. ALARM will establish socio-economic risk indicators related to the drivers of pressure on bio-diversity.
Title: Assessment of the European terrestrial carbon balance
Acronym:   CarboEurope
Project summary:   The overarching aim of the CarboEurope-IP is to understand and quantify the present terrestrial carbon balance of Europe and the associated uncertainty at local, regional and continental scale. In order to achieve this, the project addresses the three major topics: 1. Determination of the carbon balance of the European continent, its geographical patterns, and changes over time. This is achieved by (1) executing a strategically focussed set of surface based ecological measurements of carbon pools and CO2 exchange, (2) further enhancement of an atmospheric high precision observation system for CO2 and other trace gases, (3) execution of a regional high spatial resolution experiment, and (4) integration of these components by means of innovative data assimilation systems, bottom-up process modelling and top-down inverse modelling. The key innovation of the CarboEurope-IP is in its conception as to apply single comprehensive experimental strategy, and its integration into a comprehensive carbon data assimilation framework. It is solving the scientific challenge of quantifying the terrestrial carbon balance at different scales and with known, acceptable uncertainties. The increase in spatial and temporal resolution of the observational and modelling program will allow for the first time a consistent application of a multiple constraint approach of bottom-up and top-down estimates to determine the terrestrial carbon balance of Europe with the geographical patterns and variability of sources and sinks. 2. Enhanced understanding of the controlling mechanisms of carbon cycling in European ecosystems, and the impact of climate change and variability, and changing land management on the European carbon balance. This is achieved by (1) the partitioning of carbon fluxes into their constituent parts (assimilation, respiration, fossil fuel burning), at local, regional and continental scales, (2) the quantification of the effects of management on net ecosystem carbon exchange based on data synthesis, and (3) the development, evaluation and optimisation of ecosystem process models. 3. Design and development of an observation system to detect changes of carbon stocks and carbon fluxes related to the European commitments under the Kyoto Protocol. This is achieved by (1) atmospheric measurements and a modelling framework to detect changes in atmospheric CO2 concentrations during the time frame of a Kyoto commitment period, and (2) the outline of a carbon accounting system for the second Commitment period based on measuring carbon fluxes, stock changes by soil and biomass inventories, vegetation properties by remote sensing, and atmospheric concentrations. CarboEurope-IP integrates and expands the research efforts of 67 European contractors and around 30 associated institutes. CarboEurope-IP addresses basic scientific questions of high political relevance.
Additional project information:   Project website  Max Planck Inst. for Biogeochemistry (Jena) - Press release on kick-off meeting, Spoleto, January 2004 ("Public & press" section of the website) 
Title: Ensemble-based Predictions of Climate Changes and their Impacts
Acronym:   ENSEMBLES
Project summary:   ENSEMBLES will develop an ensemble prediction system for climate change based on state-of-the-art high-resolution European Earth System models. For the first time an objective probabilistic estimate of the uncertainty in future climate at the seasonal, decadal and longer time scales will be produced. The system will directly incorporate agriculture, health, food security, energy, water resources, insurance and weather risk management. Important contributions to the IPCC and the UNFCCC are expected.
Additional project information:   Project website 
Title: Integrated flood risk analysis and management methodologies
Acronym:   FLOODsite
Project summary:   FLOODsite will develop methodologies and tools for inland, estuarine and coastal flood risk analysis and management by integrating hazard, vulnerability and risk assessments. The overall aim is that of sustainable flood mitigation and defence, recognising the complex interaction between natural bio-physical and socio-economic systems to support spatial and policy planning in the context of global change and societal advance.
Title: Integrated Project to Evaluate the Impacts of Global Change on European Freshwater Ecosystems
Project summary:   EURO-LIMPACS focuses on the key drivers of aquatic ecosystem change (land-use, nutrients, acid deposition and toxic substances) and examines their interactions with climate, change, using time-series analysis, space-for-time substitution, palaeolimnology, experiments and process modelling. A central activity is the development of a toolkit for integrated catchment analysis and modelling to simulate hydrological, hydrochemical and ecological processes at the catchment scale for use in assessing the potential impact of global change under different climate and socio-economic scenarios
Title: Risk Mitigation for Earthquakes and Landslides
Project summary:   This project will address the design of earthquake resistant structures and the further development of base isolation devices which are introduced between the structures and their foundations, in order to drastically reduce the response of the structures to the earthquakes, essentially isolating the structure from the ground motion. Furthermore, the project will address the issue of mechanisms of landslide triggering and mitigation strategies. This research will increase the competitiveness of the European construction industry. The large industrial participation (18 out of 47 partners) ensures the immediate take-up of the results by the end users.
Title: Stratosphere-climate links with emphasis on the UTLS
Acronym:   SCOUT-03
Project summary:   This integrated project deals with the European predictive capability on the evolution of the stratospheric ozone layer and concentration of UV radiation at the surface, which depend on the interplay between climate change and impact of ozone depleting substances. An important aim is to provide essential advice to the policy makers involved in the Montreal Protocol.
Additional project information:   Project website  CORDIS News article  Commission News Alert 
Title: Understanding river-sediment-soil-groundwater interactions for support of management of water bodies (river basin & catchment areas)
Project summary:   Main objectives are: 1) quantify the relevant processes likely to be affected by climate change; 2) early identification of adverse trends in water quantity and quality; 3) development of integrated numerical soil-water system models reflecting all relevant transport processes at various scales.
Title: SENSOR - Sustainability Impact Assessment: Tools for Environmental Social and Economic Effects of Multifunctional Land Use in European Regions
Acronym:   SENSOR
Project summary:   Sustainability of land use is a central point of policy and management at different levels of governance. Implementation of European policies requires the development of robust tools for the assessment of different scenarios’ impacts on the environmental, social and economic sustainability of European regions.

SENSOR will build, validate and implement sustainability impact assessment tools (SIAT), including databases and spatial reference frameworks for the analysis of land and human resources in the context of land use policies. The scientific challenge is to establish relationships between different environmental, social and economic processes as characterised by sustainability indicators. Scenario techniques will be used within an modelling framework, reflecting various aspects of multifunctionality and their interactions. One focus will be on European sensitive regions, particularly those in new EU member countries, since accession related transition poses significant questions for policy makers regarding the sustainability effects of existing and proposed land use policies. SIAT will utilise the statistical and spatial data continuously collected by European and regional agencies.

Additional project information:   Project website 

Title: The nitrogen cycle and its influence on the European greenhouse gas balance
Acronym:   NitroEurope
Project summary:   The NitroEurope IP - or NEU for short - addresses the major question: What is the effect of reactive nitrogen (Nr) supply on net greenhouse gas budgets for Europe? The objectives are to:
* establish robust datasets of N fluxes and net greenhouse-gas exchange (NGE) in relation to C-N cycling of representative European ecosystems, as a basis to investigate interactions and assess long-term change,
* quantify the effects of past and present global changes (climate, atmospheric composition, land-use/land-management) on CN cycling and NGE,
* simulate the observed fluxes of N and NGE, their interactions and responses to global change/land-management decisions, through refinement of plot-scale models,
* quantify multiple N and C fluxes for contrasting European landscapes, including interactions between farm-scale management, atmospheric and water dispersion, and consideration of the implications for net fluxes and strategies,
* scale up Nr and NGE fluxes for terrestrial ecosystems to regional and European levels, considering spatial variability and allowing assessment of past, present and future changes,
* assess uncertainties in the European model results and use these together with independent measurement/inverse modelling approaches for verification of European N2O and CH4 inventories and refinement of IPCC approaches.
These objectives are met by a programme that integrates:
1) an observing system for N fluxes and pools [Component 1]
2) a network of manipulation experiments [Component 2]
3) plot-scale C-N modelling [Component 3]
4) landscape analysis [Component 4]
5) European up-scaling [Component 5] and
6) uncertainty and verification of European estimates [Component 6].
In addition to that, the project organisation comprises cross-cutting activities addressing management, databases, training and dissemination.
NEU will advance the fundamental understanding of C-N interactions at different scales and deliver: process-based models, landscape-level assessments, European maps of C-N pools, Nr fluxes and NGE, and independent verification of GHG inventories, as required under the Kyoto Protocol.

Additional project information:   Project website 

Title: The Changing Landscape of European Liberty and Security
Acronym:   CHALLENGE
Project summary:   New knowledge on relationship between external and internal security, and related changing character of relationship between security and liberty (21 partners)
Title: New Modes Of Governance
Acronym:   NEWGOV
Project summary:   Deeper understanding of new modes of governance in Europe with focus on new forms of multilevel partnership and innovations in socio-economic governance systems (36 partners)

European Atomic Energy Community - EURATOM
Title: DNA damage responses, Genomic instability and Radiation-Induced Cancer: The problem of risk at low and protracted doses
Acronym:   RISC-RAD
Project summary:   In this project, leading European research teams join forces to understand the various steps involved in the multistage process of radiation-induced tumorigenesis through detailed analysis of DNA damage responses (repair, checkpoints, apoptosis), genomic instability as well as mechanisms/genetics and modelling of radiation tumorigenesis. The research in this project will answer the following specific questions:
(i) Who is at risk?
(ii) When do the factors modifying risk exert their influence?
(iii) What are the mechanisms through which risk factors act?
(iv) Is there a link between radio-sensitivity of individuals (short term) and susceptibility to cancer (late after exposure)?
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Engineering Studies and Demonstrations of Repository Designs
Acronym:   ESDRED
Project summary:   The Integrated Project ESDRED, a joint research effort by major national radioactive waste management agencies (or subsidiaries of agencies) and by research organizations, representing nine European countries, is a major step to establish a sound technical basis for demonstrating the safety of disposing spent fuel and long-lived radioactive wastes in deep geological formations and to underpin the development of a common European view on the main issues related to the management and disposal of waste.
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: European approach to nuclear and radiological emergency management and rehabilitation strategies
Acronym:   EURANOS
Project summary:   The Integrated Project, through the commitment of 50 operational emergency management organisations, "stakeholder groups" and competent RTD institutes of many European countries to actively contribute to the following objectives, will build a fully interactive framework for initiating and promoting practice improvements of emergency management and rehabilitation strategies in Europe. A common approach and an European perspective of a more harmonised emergency management and rehabilitation strategy on the local, national and supra-national levels will be created and promoted through common emergency exercises and their thorough evaluation together with all stakeholders involved and through "stakeholder panels" on the key issues of rehabilitation. The common views on improved technical tools, methods, strategies and guidance will also create initiatives on the administrative and political levels to improve the efficacy of European emergency management and rehabilitation strategies
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: European research programme for the partitioning of minor actinides and some long-lived fission products from high active wastes issuing the reprocessing of spent nuclear fuels
Acronym:   EUROPART
Project summary:   The research to be done within EUROPART concerns the Partitioning of long-lived radionuclides (LLRs) contained in the nuclear wastes issuing the reprocessing of nuclear spent fuels. After separation, the LLRs will be destroyed in short-lived or stable nuclides by nuclear means (P&T strategy) or conditioned into stable dedicated solid matrices (P&C strategy) The target elements will be the actinides (Ans): Am to Cf for the wastes issuing the reprocessing of UOX or MOX fuels, and U to Cf for the reprocessing of spent fuels and targets (e.g. the nuclear double strata concept). The separation techniques to be studied will belong to 2 domains: hydrometallurgy, pyrometallurgy (cf. the previous FP5 programme).
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Prediction of Irradiation Damage Effects on Reactor Components
Acronym:   PERFECT
Project summary:   In nuclear power reactors, materials may undergo degradation due to severe irradiation conditions. The proposed 4 year Integrated Project has mainly for objective to develop such multi-scale numerical tools capable of simulating the effects of irradiation on mechanical and corrosion properties of materials. They will be used to solve issues related to Light Water Reactor pressure vessels and internal structures.
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Understanding and physical and numerical modelling of the key processes in the near-field and their coupling for different host rocks and repository strategies
Acronym:   NF-PRO
Project summary:   The principal objective of the Integrated Project NF-PRO is to establish the scientific and technical basis for evaluating the safety function "containment and minimisation of release" of the near-field of a geological repository for high-level radioactive waste and spent fuel. To this end, NF-PRO will investigate dominant processes and process couplings affecting the isolation of nuclear waste within the near-field and apply and develop conceptual and mathematical models for predicting the source-term release of radionuclides from the near-field to the far-field. Results and conclusions of experimental and modelling work will be integrated in performance assessment.
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.

Title: New Electron Microscopy Approaches for Studying Protein Complexes and Cellular Supramolecular Architecture
Project summary:   In this project, three currently distinct research areas will be integrated to investigate the 3D structures of biological macromolecules (e.g. proteins): cellular tomography, electron crystallography and single particle analysis.
Title: The European Epigenetics Network
Acronym:   EPIGENOME
Project summary:   These two NoE proposals are to be merged into one NoE on epigenetics. This area has recently moved to the forefront of human genetics research by providing new insights into the regulation of genes. The resulting “EPIGENOME” project aims to unravel the basic mechanisms underlying epigenetic regulation and focuses on various aspects of chromatin dynamics, the histone code and nucleosomes remodelling.
Title: Targeting cell migration in chronic inflammation
Acronym:   MAIN
Project summary:   This NoE uses an extensive array of post-genomic techniques to study chronic inflammatory responses which is a major clinical problem; currently there are poorly selective drugs and many compromise the immune system.
Additional project information:   Project website  CORDIS News article 
Title: Network of European Brain and Tissue Banks for Clinical and Basic Neuroscience
Project summary:   This project aims at structuring and spreading excellence in collecting high quality human post mortem brain tissue and at fostering research in cellular and molecular bases of brain disorders. The project will establish standardisation of neuropathological and clinical diagnosis, quality control, tissue handling, safety and ethical issues for research projects dealing with clinical or epidemiological aspects of neurological and psychiatric diseases. These standards will be disseminated as the basis for using human post mortem brain tissue in investigation methods such as expression profiling or proteomics. Activities of training and exchange of neuroscientists in this topic are also planned. Therefore, this network is expected to have a major structuring impact by establishing the ground for trans-European brain tissue research banking and a clear definition of banking standards. The consortium unites 19 different banks/departments from countries throughout Europe including 2 Hungarian partners. The project includes two SMEs, the Netherlands Brain Bank and a German company, which will assist with project co-ordination.
Title: Strengthen and develop scientific and technological excellence in research and therapy of leukemia (CML, AML, MDS, CLL, adult ALL) by cooperation and integration of the leading national leukemia network
Project summary:   The networking on clinical trials in the fields of leukemia and breast cancer. Strong points of both are to target high impact cancers, to have the capability of collating existing national or international initiatives and to develop a very strong translational rationale.
Title: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network
Acronym:   SAFE
Project summary:   The project aims at establishing non-invasive markers for prenatal and neonatal diagnosis. The main objective is to use rare foetal cells and foetal cell-free DNA that are present into the maternal circulation for prenatal purposes. The network ambitions to open the possibility for new screening tools
Additional project information:   Project website 
Title: European Vascular Genomics Network
Acronym:   EVGN
Project summary:   The planned network will bundle the scientific potential of the European vascular biology research by building a communication platform, data sharing, sharing research tools and introducing training and exchange programmes. The consortium plans to concentrate on three important determinants of the cardiovascular disease: endothelial dysfunction, plaque instability and therapeutic angiogenesis to recover ischemic organ function and reduce heart failure. Each of the three areas has potential for development of new diagnostic and therapeutic strategies that will provide permanent benefit for patients. This project integrates post-genome research into the more established biomedical and biotechnological approaches to cardiovascular disease. The network assembles the necessary critical mass and promote multidisciplinary interaction by uniting 25 basic and clinical institutions. The management is of very good quality. 28 partners (2 SMEs; 1 Industry), of 8 EU Member States plus Switzerland, are involved in the project.
Additional project information:   Project website  CORDIS News article 
Title: A European Network for Integrated Genome Annotation
Project summary:   The subject of this network is genome annotation, which is the process of 'defining the biological role of molecules (DNA, proteins, etc.) in all their complexity'. A European Virtual Institute for Genome Annotation, a European School for Bioinformatics, and extensive dissemination activities will be included.
Additional project information:   Project website  CORDIS News article  EMBL-EBI press release (PDF 49kB) 
Title: European Vigilance Network for the Management of Antiviral Drug Resistance
Acronym:   VIRGIL
Project summary:   The VIRGIL NoE will set up the first ever European vigilance network addressing current and emerging antiviral drug resistance and focuses on three pathogens (influenza and viral hepatitis B and C). However, the structure is approach- rather than pathogen- oriented, integrating several platforms addressing epidemiological studies, surveillance, optimisation of clinical management, pharmacology, basic research on the molecular mechanisms of resistance, including cell culture and animal models, host determinants, innovation and technology, spreading of excellence and training as well as the societal impact. The network could in the future be extended to new drugs and to other viral pathogens like HIV and herpes viruses (Herpes simplex, Varicella zoster, Cytomegalovirus). VIRGIL integrates 54 partners, mostly from Member States, and from Poland as well as Israel and Switzerland. Most are clinical, diagnostic and basic research departments, five are SMEs and one is a major pharmaceutical industry (BioMérieux). VIRGIL is likely to have high policy impact as a valuable contribution for the Community Network on the epidemiological surveillance and control of Communicable Diseases as well as for the Influenza Pandemic Preparedness and Response Plan, currently under development.
Title: Translating molecular knowledge into early breast cancer management: building on the BIG (Breast International Group) network for improved treatment tailoring
Acronym:   TRANS-BIG
Project summary:   The proposal aims to build a tumour tissue collection and microarray analysis network to conduct three pilot studies for subsequent randomised prospective (non-drug) studies addressing the question, whether or not adjuvant therapies can be omitted from patients whose probability of developing metastatic disease is low. Strengths were considered the existence of an already established collaboration, the quality of the investigators, the impact on populations of the proposed objectives and its translational approach.
Additional project information:   CORDIS News article 
Title: Epigenetic plasticity of the Genome
Acronym:   EPIGENOME
Project summary:   These two NoE proposals are to be merged into one NoE on epigenetics. This area has recently moved to the forefront of human genetics research by providing new insights into the regulation of genes. The resulting "EPIGENOME" project aims to unravel the basic mechanisms underlying epigenetic regulation and focuses on various aspects of chromatin dynamics, the histone code and nucleosomes remodelling.
Additional project information:   Project website  CORDIS News article 
Title: Cancer Control using Populationbased Registries and Biobanks
Project summary:   The project proposes the setting up of a network of excellence that links established bio-banks with population registries and population epidemiology experts. The relevance of the project relies chiefly on the development of a useful linked platform that makes prized sample banks and population registries available for population-based molecular epidemiology projects
Title: European Molecular Imaging Laboratories
Project summary:   The objective of this application is to develop a NoE of European molecular imaging laboratories for early stage diagnosis as well as therapeutic and prognosis assessment of cancer. Major strengths of this application were considered: 1) the quality and multi-disciplinarity of the partnership, 2) the clinical evaluation of currently available probes to provide data which can only be obtained in a timely manner by such a critical mass of expert centres, 3) the training programmes.
Title: Biology and Pathology of the Malaria Parasite
Project summary:   The recent successes in characterising genomes of Plasmodium sp. malaria parasites and their hosts provide a unique opportunity to advance fundamental knowledge and to develop novel strategies to control malaria. The size and complexity of this task require a concerted effort that no single laboratory, or even institution, has the resources or expertise to accomplish alone.Thus the leading groups involved in fundamental research in Europe join and co-ordinate their efforts in a virtual, multi centre-based 'European Malaria Research Institute'
Title: Cells into organs: functional genomics for development and disease of mesodermal organ systems
Project summary:   Very important life threatening or disabling diseases are the result of deficiencies of the mesodermal organ systems. Heart failure and strokes resulting from arteriosclerosis, kidney failure, muscular dystrophy osteoporosis, tumors and leukemia are caused either by defects in embryonic development of mesoderm containing organ systems or their function. The use of stem cells for cell and tissue replacement therapies holds great promise for treatment of degenerative diseases and injury. This approach depends critically on detailed knowledge of molecular and cellular events governing normal differentiation of target organs and tissue engineering. This project will mobilise and integrate twenty four top European groups in twelve top centers of excellence into the network for investigating development and disease of mesodermal organ systems. This task is beyond the expertise of any single research group, requiring intelligent use of the complimentary advantages of different vertebrate and invertebrate systems and combination of multidisciplinary skills. The 23 partners include groups from 7 Member States and Switzerland. SME participation is planned for a later stage of the project.
Title: Genetic testing in Europe - Network for test development harmonisation, validation and standardisation of services
Project summary:   The EuroGentest Network of Excellence focuses on the issues of harmonisation, validation and standardisation of genetic tests. It aims at improving the organisation and the harmonisation of external quality assessment/assurance schemes, at facilitating the development of guidelines and at supporting the accreditation/certification of the genetic services. The network tries to bridge a gap between research and diagnostics applications. It also intends to collect tools for the education of various stakeholders and to improve the quality of genetic counselling services. Substantial attention is paid to issues resulting from testing including legal, health policies and health economic impact, IPR (Intellectual Property Rights), ethical and social questions: confidentiality, informed consent, employment and insurance.
Additional project information:   Project website 
Title: Diagnostic Molecular Imaging
Acronym:   DIMI
Project summary:   The goal of the DiMI Network of Excellence is to integrate multidisciplinary research for the development of new probes and multimodal non-invasive imaging technology for early diagnosis, assessment of disease progression and treatment evaluation. The general objectives are to study non-invasively gene expression and function in major diseases such as neurodegeneration, stroke, heart failure, atherosclerosis and autoimmune diseases; to translate fundamental research discoveries into medical applications; to implement technology and training platforms

Additional project information:   Project website 

Title: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network
Acronym:   SAFE
Project summary:   The Special Non-Invasive Advances in Fetal and Neonatal Evaluation Network (SAFE) aims to implement routine non-invasive prenatal diagnosis and cost effective neonatal screening through the creation of long-term partnerships. The SAFE Network of Excellence will develop a series of measures to enable the rapid introduction of Non-Invasive Prenatal Diagnosis (NIPD) and Neonatal Screening (NS) throughout the EU and beyond. At present NIPD, based on a pioneering observation that circulatory cell free fetal DNA is present in maternal plasma and serum, has already begun to impact clinical practice.

Additional project information:   Project website 

Acronym:   DC-THERA
Project summary:   Dendritic cell (DC) immune-biology has enormous potential for development of new immunotherapies for cancer and infectious disease. Europe possesses a critical mass of leaders in the field who have pioneered many innovative advances and provided initial proof of principle for the approach. This NoE, DC-THERA, will integrate the activities of 25 participant groups of scientists and clinicians and 6 high quality SMEs across Europe. It will incorporate additional groups, particularly from future member states, as Associated Members of the Network Their collective expertise and resources will be forged into an ambitious Joint Programme of Activities to restructure the field. It will translate genomic, proteomic and bioinformatic information, with knowledge from molecular cell biology and pre-clinical models, into therapeutic endpoints: clinical trials of DC-based therapies for cancer and HIV. Towards this end, four thematic S&T Clusters have been defined, with a fifth for horizontal activities. The latter includes development of synergistic links with other Networks, providing added value to EC Programmes by underpinning all projects developing new vaccine strategies for major killer diseases. The Network will implement an IT-based integrated knowledge management system and provide a centralised European resource of databases for the field. DC-THERA will develop new research tools, integrate existing and new technological platforms, recruit additional support staff, and make these available as shared resources for all partners It will implement an ambitious Education and Training Programme, including new PhD studentships, a Visiting Scholars Scheme, high quality training courses, and a postgraduate degree in translational DC immunobiology. DC-THERA will contribute to the European biotechnology sector and have a major impact on European policy-making for the future. DC-THERA will evolve itself into a Centre of Excellence for DC Biology,with a lasting and global impact.

Additional project information:   Project website 

Title: Biosimulation - A New Tool in Drug Development
Acronym:   BioSim
Project summary:   The multidisciplinary BioSim Network aims at strengthening the European competence in systems biology and biosimulation. The purpose is to illustrate how modelling and simulation through a more rational utilization of the available experimental and clinical information can contribute to a faster development of new, effective drugs. The Network involves 40 partners: 26 university groups, 9 SMEs, 4 regulatory agencies and 1 large pharmaceutical company. Several partners maintain close collaborations with other large pharmaceutical companies. The partners cover a wide range of activities, from systems biology, complex systems theory and pharmacokinetics to biochemistry, cellular biology, pharmacology, endocrinology, physiology and testing of new drug candidates. BioSim also includes hospital departments performing experimental treatments of depression, various forms of tremor, and cancer. This underlines the importance that the Network ascribes to a close collaboration between experimental and theoretical research groups. The Network has six main activity areas: communication with the public and collaboration with the regulatory agencies, methodological issues, diabetes, mental disorders, cancer and cardiovascular diseases.
Additional project information:   Project website  CORDIS News article 
Title: Task-force in Europe for Drug Development for the Young
Acronym:   TEDDY
Project summary:   The Task-force in Europe for Drug Development for the Young (TEDDY) is a Network of Excellence funded under the Sixth EU Framework Programme for Research and Technological Development (FP6). The project started in June 2005 and is expected to run until 2010. It involves 17 partners from 9 EU countries, Romania and Israel. The overall aim of TEDDY is promoting the availability of safe and effective medicines for children in Europe by integrating existing expertise and good practices, as well as stimulating further developments. Today, no more than 30% of marketed drugs in Europe can be considered safe and effective with respect to their paediatric use, as a consequence of insufficient efforts in dedicated biomedical research. This gap is rooted, on the one hand, in the complexity of scientific and ethical issues linked to the design and execution of clinical trials involving children, and on the other hand, on a perception of poor profitability which seems to prevent pharmaceutical companies from investing significantly in this sector. However, along with other age groups, children as well should benefit from breakthroughs in genomics, biotechnology, pharmacology and therapeutics. The European Legislator is developing a Regulation on medicinal products for paediatric use which is likely to improve significantly the current situation. Within this general institutional framework, and in synergy with other processes and actors, TEDDY wishes to dwell on the development of a new research matrix that integrates scientific domains, assesses the impact of findings and monitors policy implementation. TEDDY aims at optimising the paediatric use of current drugs and promoting the development of new drugs.

Additional project information:   Project website 


Nanotechnologies and nanoscience, knowledge-based multifunctional materials, and new production processes and devices
Title: A network for bringing NANOtechnologies TO LIFE
Acronym:   NANO2LIFE
Project summary:   The aim of Nano2Life is to merge existing European expertise and knowledge in the field of nanobiotechnology in order to keep Europe as a competitive partner of the US and Japan and to make it a leader in nanobiotechnology transfer in 5 years time. Nano2Life aims to set the basis of a virtual European Nanobiotech Institute, focused on the understanding of the nanoscale interface between biological and non biological entities, and its possible application in the area of complex and integrated novel sensor technologies, for health care, pharmaceuticals, environment, defence, food safety, etc (24 partners).
Additional project information:   Project website  CORDIS News article  Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Self-Assembled semiconductor Nanostructures for new Devices in photonics and Electronics
Acronym:   SANDiE
Project summary:   The Network of Excellence is dedicated to the formation of an integrated and cohesive approach to research and knowledge in the field of Self-Assembled semiconductor Nanostructures (SAN). The resources and the approach of the Network spans the study of fundamental phenomena to their exploitation for the design of novel materials and structures for use in advanced electronic, photonic and optoelectronic devices. (28 partners).
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: Complex Metallic Alloys
Acronym:   CMA
Project summary:   It is proposed to contribute to a strengthening of the competitiveness of metallic materials for the benefit of European industries by the formation of a European Network of Excellence CMA developing within five years into a European Integrated Centre for the Development of New Metallic Alloys and Compounds (IDEA) (20 partners)
Title: Functionalised Advanced Materials Engineering of hybrids and ceramics
Acronym:   FAME
Project summary:   FAME will assemble, structure, integrate and expand a world class-team of researchers in multifunctional Hybrids and Ceramics as the key building block for an Institute of Advanced Functional Materials capable of remaining at the forefront of this emerging and strategically important family of materials technologies for tomorrow. FAME will be powered by 8 core-partners from Belgium, France, Germany, Spain, UK - assisted by 14 key partners chosen either for their specialisation and/or potential to develop emerging teams or centres (24 partners).
Title: Nanoscale Quantum Simulations for Nanostructures and Advanced Materials
Project summary:   This NANOQUANTA Network of Excellence proposal sets out a plan to integrate and develop the research capabilities of ten European teams in the field of the fundamental science of nanoscale systems and advanced materials, exploiting the now powerful combination of quantum-mechanical theory and computer simulation to make contact with nanoscience experimental studies and also directly with technologically relevant electronic, dynamic and optical processes (10 partners).
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: MetaMaterials ORganized for radio, millimeter wave, and PHOtonic Superlattice Engineering
Project summary:   The main scientific objective of this Network is to develop new types of artificial materials, called metamaterials, with electromagnetic properties that cannot be found among natural materials. The results of this development should lead to a conceptually new range of radio, microwave, and optical technologies, based on revolutionary new materials made by large-scale assembly of some basic elements (microscopic and nanoscopic) in unprecedented combinations. The Metamorphose initiative integrates 13 different countries around Europe.
Title: Innovative Production Machines and Systems
Acronym:   I*PROMS
Project summary:   The Network of Excellence for Innovative Production Machines and Systems (I*PROMS), funded by the EU s FP6 programme, will address the area of production research in an integrated manner in order to reshape the area and overcome its current fragmentation.

The Network will integrate the activities of leading EU research institutions in the field of production research. These institutions possess wide-ranging and complementary human and material resources. This will enable I*PROMS to cover all future research priorities in the field without being prematurely restricted to particular, narrow topics that could lose their significance with time.

The aim of I*PROMS is to develop concepts, tools and techniques enabling the creation and operation of flexible, re-configurable, fault-tolerant and eco- and user-friendly production systems that can react to changing customer needs, environmental requirements, design inputs, and material / process / labour availability to manufacture high quality, cost-effective products.

Initially, I*PROMS will address the six Manufacturing Challenges for 2020 , namely, Concurrent Manufacturing, Integration of Human and Technical Resources, Conversion of Information to Knowledge, Environmental Compatibility, Reconfigurable Enterprises, and Innovative Manufacturing Processes and Products. Research on those themes will be prosecuted by four interconnected I*PROMS clusters: Advanced Production Machines (APM), Production Automation and Control (PAC), Innovative Design Technology (IDT) and Production Organisation and Management (POM).

At present, I*PROMS comprises 30 member institutions representing 14 European countries. They will commit 139 research staff and 70 PhD students to implementing the joint programme of activities developed by the Network. In addition to the core research partners, I*PROMS will also comprise associate partners to assist with the dissemination of results and spreading of excellence to research and user communities beyond the network.
Additional project information:   Project website  CORDIS News article 

Title: Multi-Material Micro Manufacture: Technologies and Applications
Acronym:   4M
Project summary:   The existing imbalance between the ease with which batch-fabricated microcomponents and microsystems can be produced in silicon compared to the difficulties and the costs associated with their manufacture in other materials limits the speed with which new microsystems-based products are introduced into the market. At the same time, to broaden the range of these products and to multiply their capabilities requires the introduction of new materials and processes that are reasonably compatible with IC-based, batch-fabrication processes.

The main aim of 4M is to develop Micro- and Nano- Technology (MNT) for the batch-manufacture of micro-components and devices in a variety of materials into user-friendly production equipment, processes and manufacturing platforms for incorporation into the factory of the future. To achieve this the Network seeks to integrate currently fragmented R&D capacity in non-silicon microtechnologies in the ERA into a European Centre of Excellence. The establishment of such an expert resource and infrastructure at the European level is desgined to help European companies engaged in satisfying the growing demand for portable, wireless communication products and many lifestyle, health and transport related systems incorporating MNT.

The Network has 30 partner organisations, including 15 core partners - each an internationally recognised centre of excellence, from 13 member states and 2 associated countries. The Centre intends to integrate facilities and create synergistic links to on-going R&D programmes with total values exceeding €110 million and €63 million, respectively. More than 150 researchers will perform the 4M Joint Programme of Activities, organised into eight specialist technology and application cluster groups. The linking of this expert resource to business needs through collaborative working of multidisciplinary partner groups aims to impact on Europe's competitiveness in the rapidly growing global market for microsystems.
Additional project information:   Project website 

Title: Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds
Project summary:   The network will bring together Europe's leading academic centres and several complementary industrial players in a multi-disciplinary consortium to conduct and structure research that is able to compete in the internationally arena, namely with USA and Japan. The size of the network (26 partners from 14 countries, including 10 of the EU member states), and the selection of its original members, was designed in order to join together the critical mass and all the expertises needed to be an unavoidable world reference on the topic of tissue engineering of bone and cartilage (26 partners)
Title: NoE Research and facilities directed at instrumentation for manufacturing and analysis of single molecules and individual nanoclusters, targeted at life sciences
Acronym:   FRONTIERS
Project summary:   Frontiers will focus on the analysis and manipulation of the bio environment as well as using the experience of the consortium in technology/integration to create these systems/mutual interaction to conceptualize/design them (11partners).
Title: Nanostructured and functional polymer-based materials and Nanocomposites
Project summary:   The main objective of NANOFUN-POLY is to generate a Network of Excellence designed to become the European reference point on Multifunctional Nanostructured Polymers and Nanocomposite Materials. This objective will be reached through a trans-disciplinary partnership of 150 scientists combining excellence in different scientific areas, where the synergy of international excellence and multidisciplinary approaches will lead to develop and spread knowledge in innovative functional and structural polymer-based nanomaterials and their sustainable technologies (25 partners).
Title: The European Polysaccharide Network
Project summary:   Polysaccharides (like cellulose or starch) are by far the polymers produced in greatest quantity by Nature. This network aims to organize the EU scientific community around a network in order to promote the use of these renewable raw materials as industry feedstock for the manufacturing of advanced, multifunctional materials. The Network is composed of 16 large and small world class research groups from 9 countries, covering all needed expertise regarding polysaccharide types and scientific disciplines (16 partners)
Title: Nanoanalysis using finely focused ion and electron beams
Acronym:   NANOBEAMS
Project summary:   In order to match the resolution required for the development of nanomaterials and provide analytical information, this network concentrates on analytical techniques using focused ion and electron beams: Static and dynamic Secondary Ion Mass Spectrometry (SIMS), Auger Electron Spectroscopy (AES), Analytical Transmission Electron Microscopy (TEM) (13 partners)
Title: Expanding membrane macroscale applications by exploring nanoscale material properties
Project summary:   The NanoMemPro Network provides answers to the eminent needs for coordinated future R&D of membrane science and technology in Europe and smartly links nano and macro scale in both basic and applied researches, more specifically by establishing a European virtual laboratory, a European Task force, coordinating and orienting European membrane research according to the society's needs (14 partners)
Title: INSIDE-PORES - IN SItu study and DEvelopment of processes involving nanoPORE Solids
Project summary:   INSIDE_POReS NoE aims at the congregation of diverse expertise in the nanoporous materials field in order to develop methodologies for the "in situ" application of both static and dynamic techniques and their combinations as a tool to probe the evolution of properties, which are relevant to specific processes that involve nanoporous solids (14 partners)
Title: Soft Matter Composites - An approach to nanoscale functional materials
Acronym:   SOFTCOMP
Project summary:   The proposed network of excellence aims to establish a knowledge base for an intelligent design of functional and nanoscale soft matter composites. It will do so in overcoming the present 2 fold fragmentation of this extremely important field for the development of new materials at the interface of non-living and living matter where the delicate self organizing principles of polymeric, amphiphilic and colloidal matter are ubiquitous (32 partners)
Title: Knowledge-based Multicomponent Materials for Durable and Safe Performance
Acronym:   KMM-NoE
Project summary:   The KMM-NoE is proposed by 45 partners from leading European research institutes, university departments, SMEs and industry ?n the field of KMM designed for enhanced performance in highly demanding loading and environmental conditions (thermo-mechanical and impact loading, high strain rates and temperature regimes, aggressive chemical environment and combinations thereof). Such regimes are typical of advanced applications in aerospace and automotive industry, turbo-machinery industry, tribology, electronic devices, biological implants, microsensors, etc (45 partners).

Title: European Windtunnel Association
Acronym:   EWA
Project summary:   The goal of EWA is to form a European Wind Tunnel Association for aeronautical applications and related advanced measuring technologies with a uniform and cohesive management structure and a technical organisation to execute a joint programme of activities. Its partnership comprises in total 14 partners from 8 European countries, including 3 industrial operators, 3 commercial operators, 7 research organisations, and one organisation for post-doctoral education. The wind tunnels, which are of utmost importance for industrial wind tunnel testing for aeronautics in Europe, are operated by 11 of the 14 partners. Five partners are leading developers of advanced measuring technologies for wind tunnels in Europe. Due to the complexity of the organisational structures and missions of the existing wind tunnel organisations, EWA will proceed in a four-step approach (Preparation, Harmonisation, Implementation and Presentation of Integration). In particular, EWA will integrate and strengthen the European research area by building lasting relationships and interdependencies between the major European wind tunnel operators and developers of advanced measuring technologies. This will allow all partners to offer to researchers and the aerospace industry a comprehensive set of services and will bring new experimental techniques into operation in industrial wind tunnels much faster than in the past. Methods for harmonising standards and for assessing the quality of experimental simulation as well as methods to harmonise wind tunnel test techniques will be developed jointly. Due to this approach considerable improvements in quality and reduction of costs for wind tunnel testing can be expected. These core activities will be complemented by information exchange with industrial end users, with SME's for manufacturing wind tunnel models and/or instrumentation, with universities for training students and for developing new measuring technologies and by training and exchange of personnel.
Title: Global Monitoring for security and stability
Acronym:   GMOSS
Project summary:   The objective of GMOSS to gather Europe's research community into a network of excellence that is able to work together towards an enhanced European capability in monitoring for civil security applications through a joint programme of research whose priorities are agreed with end-users and where each partner's effort contributes to the overall objectives. The partners will share staff, software and infrastructure in work which includes
  • research into solutions for remote monitoring including the development and assessment of airborne (manned and unmanned) and satellite sensors as well as the ground and communication systems necessary to make the images and signals available for processing as rapidly as possible.
  • development and assessment of tools and algorithms that can automate the processing, interpreting, cataloguing and archiving of images including classification, feature extraction, change detection, map generation and visualisation
  • understanding how to use this information to provide the EU with the knowledge it needs to act more effectively and efficiently in four main areas:
    a) humanitarian aid - including early warnings, vulnerability assessment, information flow between field and headquarters personnel;
    b) reconstruction - including damage assessment, mine clearance operations;
    c) verification of non-proliferation treaties including characterization of nuclear and chemical facilities, development of tools for remote verification of treaties, localization of testing sites;
    d) police operations including protection of Europe's security through vulnerability assessment and developing stability beyond the EU's borders through better border control, conflict prevention and infrastructure monitoring. And developing a identifying at a European level future organisational scenarios that could enable the timely communication and exchange of critical information and proper decision-taking mechanisms in the civil security domain.

Additional project information:   Project website 

Title: European Nutrigenomics Organisation - linking genomics, nutrition and health research
Acronym:   NUGO
Project summary:   This Network of Excellence (22 participants) aims to integrate and develop nutritional genomics in Europe. Nutrition and health research is focussed on the prevention of disease by optimising and maintaining cellular, tissue, organ and whole-body homeostasis. This requires understanding, and ultimately regulating, a multitude of nutrient-related interactions at the gene, protein and metabolic levels. This project will enable nutrition research to fully complement the biomedical and pharmacological research communities that are currently using genomics for the development of curative therapy. A key objective of the network will be the development, data warehousing and exploitation of nutrition and health-related bioinformatics for the benefit of European nutrition researchers, and for the community as a whole.
Additional project information:   Project website 
Title: Network of prevention and control of zoonoses
Acronym:   MED-VET-NET
Project summary:   Diseases naturally transmitted from animals to man, termed zoonoses, constitute major public health risks and generate emerging disease problems. Such diseases, especially when food borne, have significant social and financial impacts in Europe and need to be addressed across the whole food supply chain. The overall objective of this Network of Excellence (10 participants) is to integrate veterinary, medical and food scientists in the field of food safety at European level, in order to improve research on the prevention and control of zoonoses, including food borne diseases, while taking into account the public health concerns of consumers and other stakeholders throughout the food chain. The network comprises 5 veterinary and 5 public health institutes in 8 European countries. All partner institutes have national reference laboratory-based responsibilities for the prevention and control of zoonoses. The network will develop activities to enable integration, including structured and systematic communications, and training. The programme will address zoonotic agents selected on the basis of importance in Europe and covering four thematic areas: epidemiology, host-microbe interactions, detection and control and risk analysis.
Additional project information:   Project website  CORDIS News article 
Title: Prevention, control and management of prion diseases
Project summary:   This Network of Excellence (52 participants) is expected to provide European researchers with an effective communication strategy with the public, with policy makers and between themselves, allowing the sharing of prior, current and future knowledge. It is expected to provide better value for money from European and nationally funded research, allow the better exploitation of knowledge and promote a concerted European response to various issues or future TSE crises.
Additional project information:   Project website  CORDIS News article  Commission News Alert 
Title: European Animal Disease Genomics Network of Excellence for animal health and food safety
Acronym:   EADGENE
Project summary:   This Network of Excellence (13 partners) will bring together sufficient excellence and resources to make a real difference to animal and human health, and improve the quality of animal products. Integrating activities will ensure that all partners have easy and durable access to the best available facilities, biological resources, technological platforms, software, analytical tools and knowledge. The joint research programme will ensure that this integration results in high quality research that is directed towards the most pressing issues, and presents the best opportunities to address European concerns. The network will: create a durable virtual laboratory in genomics of host-pathogen interactions; co-ordinate and orient European animal genomics and disease research; apply genomics as a tool to improve animal health, food quality and safety.
Additional project information:   Project website  CORDIS News article  Commission News Alert 
Title: Chemicals as contaminants in the food chain: An NoE for research, risk assessment, education and information
Acronym:   CASCADE
Project summary:   This Network of Excellence (19 participants) seeks durable coordination and integration of European research on human health effects of chemical residues in the numerous chemicals, present at even low levels in the environment and food or drinking water, that interfere particularly with the function of a cellular structure called nuclear receptor, which, when perturbed by chemicals, is linked to development of cardiovascular disease, obesity, diabetes, decline in fertility, breast, prostate, colon cancer, neurodegenerative disease, etc. Assessing the risk for humans, especially women, new-born children, and other susceptible populations has proved difficult, owing to insufficient information on the mechanisms of action of these chemical residues, their levels in the food chain, differences in sampling techniques and lack of reliable biological markers. To address these issues competently and responsibly requires efficient integration of key areas of European research. Deliverables will include training programmes and provision of rationalised information for assessing the risk that these compounds pose to human health. It is also important that to channel scientific information of potential use to consumers and for implementation of legislative measures.
Additional project information:   Project website  CORDIS News article 
Title: Global Allergy and Asthma European Network
Acronym:   GA2LEN
Project summary:   This Network of Excellence (27 participants) will study allergy and asthma throughout the course of life, including intrauterine life and foeto-maternal interface, interaction between genetic and environmental factors in early life and development of allergies, via existing and new birth cohorts. It will establish an international network of European centres of excellence that will conduct specific integrated multidisciplinary research programmes on issues relating to environment (including outdoor and indoor pollution), nutrition, lifestyle (including occupation), infections and genetic susceptibility. Genetic and epidemiological studies will address gene-environment interactions that might underpin the dramatic increase in allergy rates in the EU in the last few decades. The work also encompasses, through region-specific epidemiological studies, the impact of nutritional status on allergic disposition, and the dissemination of information to patients and public, as a fundamental task to reduce the socio-economic burden of allergy and asthma.
Additional project information:   Project website  Europa news article  Commission News Alert 

Title: Advanced lithium energy storage systems based on the use of nano-powders and nano-composite electrodes/electrolytes
Acronym:   ALISTORE
Project summary:   A number of internationally leading research groups from 7 member states and 3 candidate/associated members working in lithium-ion batteries are join their efforts within this Network of Excellence to reduce redundancy, ensure complementarity, optimize collaboration to achieve vital research objectives, and share expensive facilities and resources in the field of nano-materials applications for battery design. They represent more than 70% of the European Li battery research in the EU-25.
Title: Network of Excellence on Geological Sequestration of CO2
Acronym:   CO2GeoNet
Project summary:   This NoE CO2GEONET contains a critical mass of research activity in the area of geological CO2 storage. The main aim of CO2GEONET will be to integrate, strengthen, and build upon the the momentum of previous and existing European R&D, as well as project European excellence internationally, so as to ensure that Europe remains at the forefront of CO2 underground storage research.
Title: Overcoming Barriers to Bioenergy
Project summary:   Network of Excellence to investigate the dismantling of barriers to bio-energy production. The joint plan of activities will cover all processes, components and methods necessary to establish successful "bioenergy chains" to produce heat, electricity and ...
Title: Safety of Hydrogen as an Energy Carrier
Acronym:   HySafe
Project summary:   The HySafe network of excellence will focus on safety issues relevant to improve and co-ordinate the knowledge and understanding of hydrogen safety and support the safe and efficient introduction and commercialisation of hydrogen as an energy carrier of the future, including the related hydrogen applications. The overall goal of HySafe is to contribute to the safe transition to a more sustainable development in Europe by facilitating the safe introduction of hydrogen technologies and applications.

Title: Energy conversion in engines
Acronym:   ECO-ENGINES
Project summary:   The objective of this NoE is to set-up a Virtual Research Centre (VRC) on advanced engine combustion modes for road transport, with special emphasis on the use of alternative and renewable fuels, and to establish it as a world reference in the domain. The VRC will structure the excellence of European research on all aspects of new generations of high efficiency, low CO2 and noise, near zero emission engine combustion processes like CAI, HCCI or CCS, and other emerging high potential techniques.
Title: European rail research network of excellence
Acronym:   EUR2EX
Project summary:   The strategic objectives of the European Rail Research Network of Excellence are:
  1. To integrate the fragmented European Rail Research landscape by networking together the critical mass of resources and expertise to provide European leadership and be a world class player
  2. To promote the railway contribution to sustainable transport policy
  3. To improve the competitiveness and economic stability of the railway sector and industry.
Title: Network of excellence on advanced passive safety
Acronym:   APSN
Project summary:   Following the mobilisation of critical R&D mass on vehicle passive safety in EU Thematic Network projects like PSN & EVPSN2, this Network of Excellence aims at a durable, integrated European vehicle passive safety research & implementation programme and creation of a Virtual Centre of Excellence (VCE). It is the ultimate aim of the NoE to strive for the creation of a permanent organisation (VCE) in the field of passive safety for road transport at European level.
Title: Network of excellence in marine structures
Acronym:   MARSTRUCT
Project summary:   The overall objective of the network is to improve the comfort, effectiveness, safety, reliability and environmental behaviour of ship structures through the application of advanced structural and reliability assessment within design, fabrication and operation, leading to increased public and commercial confidence in the competitiveness and use of waterborne transportation.

Title: A Long-term Biodiversity, Ecosystem and Awareness Research Network
Acronym:   ALTER-NET
Project summary:   By formally integrating the existing capability of national research centres of excellence, ALTER-NET will create a quasi-institute, a European long-term interdisciplinary research facility for research on the complex relationship between ecosystems, biodiversity and society. Research will contribute directly to our understanding of the inter-relationship between biodiversity and the services it provides to society and vice versa.
Title: Atmospheric composition change: an European network
Acronym:   ACCENT
Project summary:   The joint programme of ACCENT activities deals with a common European strategy for research on atmospheric science, focussing on aerosols, biosphere-atmosphere interactions and transport and transformation of pollutants. Integration will be achieved by making available common facilities, databases, infrastructure and through common activities as training and education, assessment of scientific results and interface with the general public.
Title: Implementation of high-throughput genomic approaches to investigate the functioning of marine ecosystems and the biology of marine organisms.
Acronym:   Marine Genomics
Project summary:   Experts in genomics, proteomics and bioinformatics from several Centres of Excellence in genomics in Europe will be grouped and networked with marine biologists who can make use of high-throughput genomics data. The network aims among others at sharing existing technological platforms; enabling access to major genomic centres; establishing a common DNA Stock Centre and a common Bioinformatics Centre. Marine Genomics will also develop complementary dissemination strategies, targeting public, private and institutional communities with the purpose of enhancing the integration of marine biologists in the ERA.
Additional project information:   Project website  CORDIS News article  ImaGene: a Photo Contest on Marine Genomics 
Title: Marine biodiversity and ecosystem functioning
Acronym:   MARBEF
Project summary:   The project will: develop a European "taxonomy clearing system"; establish a joint training programme; form a Board of Governance to establish links with funding agencies and policy makers at national and European levels. In so doing, MARBEF will also contribute to other EU policies such as EU biodiversity research strategy and the CFP, and to Member State biodiversity research strategies as well as international initiatives and agreements (GLOBEC, CoML, DIVERSITAS etc.).

Title: Efficient And Democratic Governance In A Multi-Level Europe
Acronym:   CONNEX
Project summary:   Building excellence in a Europe wide and interdisciplinary research community on multilevel governance and democratic legitimacy (43 partners)
Title: International Migration, Integration and Social Cohesion in Europe
Acronym:   IMISCOE
Project summary:   Integration of research capacities in two interrelated areas: the processes of international migration and the processes of settlement and integration of immigrants (19 partners)
Title: Policies For Research and Innovation in the Move towards the European Research Area
Acronym:   PRIME
Project summary:   Lasting integration of European capabilities in three fields: changing dynamics of knowledge production in new leading sciences, changing relationship between science and society, and governance of RTD policy (44 partners)

European Atomic Energy Community - EURATOM
Title: Physics and chemistry of actinides
Acronym:   ACTINET
Project summary:   One major issue for nuclear energy, requiring intensive R&D programmes, remains a broadly agreed approach to waste management, in particular long-lived waste components. R&D is also needed to explore new concepts for nuclear energy generation that make better use of fissile material and generate less waste. Actinide science is one central theme to respond to these needs. The general objective of ACTINET is to gather the concerned scientific community through a network, aiming to reach sustainability in a few years. Knowledge dissemination, education and training activities through the network will ensure highest level of expertise in Europe. Transnational access to experimental facilities will valorise existing and future facilities and optimise their use.
Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.
Title: SARNET: a proposal of network of excellence for a sustainable integration of European research on severe accident phenomenology and management
Acronym:   SARNET
Project summary:   In spite of the accomplishments reached in severe accident research, a limited number of specific items remain where research activities are still necessary to reduce further uncertainties that are considered of importance for nuclear reactor safety and to consolidate severe accident management plans. Facing and anticipating budget reductions, 52 European R&D organizations, including technical supports of safety authorities, industry, utilities and universities, have decided to join their efforts in SARNET in a durable way to resolve outstanding severe accident safety issues for enhancing the safety of existing and future NPPs. SARNET will:
  • tackle the fragmentation existing in defining/carrying out research programmes;
  • harmonize and improve Level-2 PSA methodologies;
  • diffuse the knowledge to Associated Candidate Countries more efficiently;
  • bring together top scientists in severe accident research so as to be a world leader in advanced computer tools for severe accident risk assessment.

Additional project information:   Fact Sheet (on CORDIS) This link searches based on the project acronym, so it is possible that there are no results if the project has not yet been loaded into the CORDIS database.