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Europa  > European Commission  > Research > EURAB > Members > CV
 

* EURAB 2 Curriculum Vitae


 

Professor Christine VAN BROECKHOVEN

Professor Christina van Broeckhoven

Scientific Director, Department of Molecular Genetics VIB8, Flanders Interuniversity Institute for Biotechnology -
Professor at the University of Antwerp
University of Antwerp - Campus CDE
Parking P4, Building V, Room 0.10
Universiteitsplein 1
BE - 2610 Antwerp

Tel: +32 3 265 1001 or +32 3 265 1002
Fax: +32 3 265 1012
E-mail: christine.vanbroeckhoven@ua.ac.be


Born in 1953.

CURRENT AFFILIATIONS
University of Antwerp (UA)
Born-Bunge Foundation (BBS)
Flanders Interuniversity Institute for Biotechnology (VIB)

EDUCATION

Degree Institution Year Awarded
Bachelor in Chemistry University of Antwerp (RUCA) 1973
Master in Biochemistry University of Antwerp (UIA) 1975
Ph.D. Molecular Biology University of Antwerp (UIA) 1980
D.Sc. Molecular Genetics University of Antwerp (UIA) 1994

Scientific Career

Degree Institution Year
Ph.D. Student UIA 1975
Postdoctoral Fellow Provincial Institute of Hygiene 1979
Research Assistant UIA 1983
D.Sc. Molecular Genetics University of Antwerp (UIA) 1994
Research Fellow National Fund of Scientific Research (NFWO) 1989
Assistant Professor UIA 1990
Research Director Born-Bunge Foundation (BBS) 1990
Associate Professor UIA 1995
Scientific Director Dept. of Molecular Genetics (VIB8)
Flanders Interuniversity Institute for Biotechnology (VIB)
1995
Professor UIA 1997
Ordinary Professor UIA 1999

PROFESSIONAL CARREER

Degree Company Period
Consultant Innogenetics Inc. 1990-1993
Consultant Janssen Pharmaceutica N.V. 1995-2001

SCIENTIFIC PUBLICATIONS (per 01.06.2004)
Articles in Books: 45
Articles in International Journals: 370
Articles in National Journals: 29

PRIZES

  • Prize Divry of the Belgian Society of Neurology, Brussels, Belgium, October 21, 1991: 'Gene technology and Alzheimer disease'.
  • Co-recipient of the Potamkin Prize of the American Academy of Neurology, New York, USA, April 27, 1993: 'APP mutations and cerebral haemorrhages'.
  • Scientific Prize Joseph Maisin of the National Fund of Scientific Research (NFSR), Brussels, Belgium, July 5, 1995: Medical and Biological Sciences ‘Molecular Genetics of Alzheimer disease: Identification of genes and gene mutations’.
  • Prize Marie-Thérèse De Lava, of the King Boudewijn Foundation, Brussels, Belgium, November 21, 1995: Ageing ‘Molecular Genetics of Alzheimer Disease'.
  • Co-recipient of the Scientific Prize Upjohn Inc. of the National Fund for Scientific Research (NFSR), Brussels, Belgium, December 18, 1995 ‘Molecular genetic research of neurodegenerative disorders: peripheral neuropathy of Charcot-Marie-Tooth disesase (CMT type 1)’.
  • Co-recipient of the Lundbeck-Prize of the Belgian College of Neuropsychopharmacology and Biological Psychiatry (BCNBP), Brussels, Belgium, June 3, 1997: The presenilin genes: A new family involved in Alzheimer disease pathology’.
  • Special Honor Award for Women in Science 2002, with the support of L’Oréal/Unesco, Brussels, Belgium, January 23, 2003

HONORS

  • Alzheimer Professor Chair, University of Leiden, Department of Neurology 1996
  • Associate Member of the Royal Flemish Academy of Sciences and Art - Belgium, 1999
  • Guest Scientist at The Scripps Research Institute La Jolla, San Diego, USA, 2001

PROFESSIONAL SOCIETY ACTIVITIES

International


Current Activities


European Charcot-Marie-Tooth Consortium: Consortium Leader and President of the Steering Committee, 1991
Federation of the European Neurological Societies (FENS): Scientific Panel on ‘Genetics, including Molecular Genetics’, 1993
EU – Expert Group on Women in Science, Life Sciences, 2002
European College of Neuropsychopharmacology (ECNP), Member of the Scientific Advisory Panel ‘Degenerative Disorders’, 2003
EU – Evaluator – VI frame work, 2002-2006
EU – Evaluation Panel – EU program on ‘Life Sciences: Genomics and Biotechnology for Health’ – Area ‘Fundamental Genomics’, 2004
EU – European Research Advisory Board (EURAB), Member, 2004 - 2007
Human Frontier Science Program (HFSP), Council of Scientists 2001
The International Society of Psychiatric Genetics: Board, 1994
The International Society of Psychiatric Genetics: International Scientific Programme Committee, 1996, 1998, 1999, 2001, 2002
The International Society of Psychiatric Genetics: Vice President, 2000
The International Society of Psychiatric Genetics: Chair & Local Organiser Xth World Congress on Psychiatric Genetics, 2002, 2003, 2004
USA, Faculty of 1000 Medicine: Faculty member and member of the Evaluation Board, Section Head ‘Alzheimer’s disease’, 2004
USA, Alzheimer Research Forum, Member of the Scientific Advisory Board, 2004
USA, Mayo Clinic Jacksonville, Program Project ‘Genetic and functional studies to determine the role of tau in PSP’, Member of the External Advisory Board, 2004

Past Activities

European Society of Human Genetics: Board, 1992-1997
European Society of Human Genetics: Chairperson of the Scientific Programming Committee, 1993-1994
European Society of Human Genetics: Scientific Programming Committee, 1993-1997
European Neuro-Muscular Centre (ENMC): Research Committee, 1994-1999
EU – Concerted Action on ‘Cellular Aging and Disease’ (EURAGE): Biology of Aging Group, 1989-1991
EU – BIOMED2 Ad Hoc Working Group on Human Genome Research, 1995-1996
EU – Evaluation panel – EU Projects Human Genome Analysis, 1996
EU – Evaluator – IV frame work – BIOMED2 programme, 2nd Call, 1996-1998
EU – Evaluation Panel – EU Training and Mobility of Researchers – Life Sciences, 1997
EU – National Contact Person of BIOMED2 on ‘Ageing’ for the Ad hoc Advisory Committee (AHAC) to CREST for the co-ordination of RTD Policies, 1998
EU – Evaluator – V frame work, 1999-2000
EU – High Level Expert Group I on Chronic and degenerative diseases, genomics, neurosciences, 1999-2003
EU – Expert for the Assessment of Expressions of Interest (EoI’s) ‘Studying the brain and combating diseases of the nervous system’, 2002
Human Genome Organisation (HUGO): Community Editor of chromosome 21, 1993-1998
The International Society of Psychiatric Genetics: International Advisory Committee, 1993
Alzheimer’s Disease and Related Disorders: International Advisory Committee, 1994
Alzheimer’s Disease and Related Disorders: Scientific Programme Committee, 1997-1998
USA - Charcot-Marie-Tooth Association (CMTA): Medical Board, 1998-2004

National

Current Activities

Born-Bunge Foundation (BBS): Scientific Advisory Board, 1990
Flanders Interuniversity Institute for Biotechnology (VIB): Board of Scientific Directors, 1995
Flemish Institute for the advancement of Scientific and Technological Research in Industry (IWT): Evaluator of the PhD & Postdoc fellowships, 1995
Fund for Scientific Research – Flanders (FWO): Commission Medical Cell Biology and Genetics 1997 – 2006
Flemish Board of Scientific Policy (VRWB): Member, 2000-2002
National Fund for Scientific Research (NFSR): Working party 'Ethical genetics', 1994
Federal Ministry of Science Policy, Member of the High Level Group 3% for Research, 2004
Alzheimer Liga Belgium: Scientific Advisory Board, 1990
CMT-Belgium: Scientific Advisory Board, 1991
Medical Women's Association of Belgium: Board, 1995
Belgian College of Neuropsychopharmacology and Biological Psychiatry: Councillor, 2000
King Boudewijn Foundation – Workgroup Human Genome, 2001
International Alzheimer Research Foundation (IARF): Member of the Scientific Advisory Board, 1996
International Alzheimer Research Foundation (IARF): Chair, 2003
Finland – Academy of Finland, Research Council for Health: Scientific Expert, 2002
Germany - German Ministry for Science – Kompetenznetzwerk ‘Mednet Stroke’: Advisory Board, 1999
Germany - National Medical Network on Dementias by the German Federal Ministry of Education and Research (BMBF): International Advisory Board, 2000
Germany - Max-Delbrück-Center for Molecular Medicine, Berlin: Member of the Expert group, 2001
Italy - Italian Téléthon Foundation: Scientific Committee, 2001
Sweden - Center for Molecular Medicine, Karolinska Institute: Advisory Board, 1996
The Netherlands: Netherlands Organisation for Scientific Research (NWO) – Human Genome Analysis’: Evaluation Committee, 1997
The Netherlands: Netherlands Organisation for Scientific Research (NWO) – The Research Institute ‘Diseases of the elderly’: International Expert Committee, 1999
UK – Alzheimer Research Charity: Charity Trustee, 1998

Past Activities

Provincial Centre for the Detection of Metabolic diseases: Steering Group, 1990-1993
Institute for Scientific Research in Industry and Agriculture (IWONL), Evaluator of fellowships, 1991-1993
Belgian Society for Neurology: Jury Member Divry, 1994
Belgian Society of Biochemistry and Molecular Biology: Board Member, 1996-1999
Administration for Science and Innovation (AWI), Jury Member of the Commission, 1999
The Royal Academy of Medicine – Belgium, Jury Member for the Prize of the Flemish Scientific Foundation for Biomedical Sciences 2004
MILQTL-programme: Review Panel, 1994 – 1998
Germany - 11.Jahrestagung der Deutschen Gesellschaft für Humangenetik: Scientific Programme Committee, 1998 – 1999
Germany - National Network on genomic research – area neurological / neuropsychiatric diseases by the German Federal Ministry of Education and Research (BMBF): Reviewing Board, 2001
The Netherlands - Internationale Stichting Alzheimer Onderzoek (ISAO): Scientific Advisory Board, 1995-1997
The Netherlands – Ministry of Public Health: Gezondheidsraad: Commission DNA-Diagnostics, 1995 – 1998
UK – Alzheimer’s Research Trust: Scientific Advisory Board, 1993-1997

PROFESSIONAL MEMBERSHIPS

International

European Neuroscience Association, 1991
European Society of Human Genetics, 1991
Federation of European Neuroscience Societies, 1996
American Association for the Advancement of Science, 1991
Society for Neuroscience, 1990
The American Society of Human Genetics, 1987
The International Society of Psychiatric Genetics, 1992

National

Belgian Society of Biochemistry, 1988
Belgian Society for Cell Biology, 1994
Belgian Society of Neurology, 1990
Belgian Society for Neuroscience, 1996
Belgian College of Neuropsychopharmacology and Biological Psychiatry, 2000
Belgian Society for Human Genetics, 2002
Stichting Lieve Nijs vzw: Leven met dementia, 1993
The Society for Forensic Haemogenetics, 1988-1989

GRANTS

Supervisor

Special Research Fund – UA/UIA
Emerging Technology Centre (VLAB)
Flanders Interuniversity Institute for Biotechnology (VIB)
Fund for Medical Scientific Research (FGWO)
Fund for Scientific Research – Flanders (FWO)
National Fund for Scientific Research (NFWO)
Ministry of the Flemish Community - Education- Concerted Action (GOA)
Ministry for Programming Scientific Policy (DPWB)
The Federal Office for Scientific, Technical and Cultural Affairs (DWTC)
Medical Foundation Queen Elisabeth (GSKE)
International Alzheimer Research Foundation (IARF)
Innogenetics
Janssen Research Foundation (JRF)
Association Française contre les Myopathies (AFM)
European Science Foundation (ESF)
Commission of the European Communities (EEC)
American Health Assistance Foundation (AHAF)
Muscular Dystrophy Association, USA (MDA)
Focused Giving Programme, Johnson & Johnson
Alzheimer Association (AA)

Co-supervisor

Fund for Collective Scientific Research (FKFO)
Netherlands Organization for Scientific Research (NWO)
Hersenstichting Nederland
Internationale Stichting Alzheimer Onderzoek (ISAO)
Alzheimer Association (AA)

PATENTS

European

• European Patent Application EP 91/401220.8 Patent: 'Process for the in vitro diagnosis of chromosomal anomalies liable to be correlated with CMT1a disease', Date of Filing: 7.5.1991, Applicant: Innogenetics, Inventors: Van Broeckhoven, C., Raeymaekers, P., De Jonghe, P., Martin, J-J.
• European Patent Application EP 92/400771.9 Patent: 'Mutated form of the beta-amyloid precursor protein gene', Date of Filing: 20.3.1992, Applicant: Innogenetics, Inventors: Van Broeckhoven, C., Martin, J-J., Hendriks, L., Cras, P.
• European Patent Application EP 97/268.04.9, Patent: ‘Mood disorder gene’, Date of Filing: 18.12.1997, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: Del-Favero, J., Raeymaekers P., Van Broeckhoven, C.
• European Patent Application EP 00/202362.0, Patent: ‘ A novel APP mutation associated with an unusual Alzheimer’s disease pathology’, Date of Filing: 06.07.2000, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: Kumar-Singh, S., De Jonghe, C., Cruts, M., Van Broeckhoven, C.
• European Patent Application EP 01/203558.0, Patent: ‘Novel brain expressed CAP-2 gene and protein associated with bipolar disorder’, Date of Filing: 17.09.2001, Applicant: Janssen Pharmaceutics, Inventors: Del-Favero, J. & Van Broeckhoven, C.
• European Patent Application EP 01/202214.1, Patent: ‘Novel brain expressed NCAG1 gene and protein associated with bipolar disorder’, Date of Filing: 11.06.2001, Applicant: Janssen Pharmaceutics, Inventors: Del-Favero, J. & Van Broeckhoven, C.
• European Patent Application EP 02/077724.9, Patent: ‘Diagnostic test for the detection of peripheral Neuropathy’, Date of Filing 09.07.2002, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: C. Van Broeckhoven, V. Timmerman & P. De Jonghe
• European Patent Application EP 03076033.4 (second priority), Patent: ‘Diagnostic test for the detection of peripheral Neuropathy’, Date of Filing 08.04.2003, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: C. Van Broeckhoven, V. Timmerman & P. De Jonghe
• European Patent Application EP 03104181.7, Patent: ‘Diagnostic tests for the detection of motor neuropathy’, Date of Filing 13.11.03, Applicant: Interuniversity Institute for Biotechnology (VIB), Inventors: Van Broeckhoven, C., Timmerman, V., De Jonghe, P. & Irobi, J.
• European Patent Application EP 04102066.0, Patent: ‘Diagnostics based on a dementia-causing gene’, Date of Filing 12.05.2004, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: R. Rademakers, M. Cruts &C. Van Broeckhoven
• European Patent Application EP 04102088.4, Patent: ‘Diagnostics based on an epilepsy causing gene’, Date of Filing 13.05.2004, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: L. Claes, P. De Jonghe & C. Van Broeckhoven

International

• US Patent Application 08/133.248, Patent: 'Mutated form of the beta-amyloid precursor protein gene', Date of Filing: 08.10.1993, Applicant: Innogenetics, Inventors: Van Broeckhoven, C., Martin, J-J., Hendriks, L., Cras, P.
• International Patent Application PCT/EP 98/08543, Patent: ‘Mood disorder gene’, Date of Filing: 17.12.1998, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: Del-Favero, J., Raeymaekers, P.,Van Broeckhoven, C.
• International Patent Application PCT/EP 99/04106, Patent: 'Novel fragmentation vectors and uses thereof', Date of Filing: 11.06.1999, Applicant: Flanders Interuniversity Institute for Biotechnology (VIB), Inventors: Del-Favero, J., Van Broeckhoven, C.
• International Patent Application PCT/EP01/07830, Patent: A novel APP mutation associated with an unusual Alzheimer’s disease pathology’, Date of Filing 06.07.2001, Applicant: Interuniversity Institute for Biotechnology (VIB), Inventors: Kumar-Singh, S., De Jonghe, C., Cruts, M., Van Broeckhoven, C.
• International Patent Application JAB1746-PCT, Patent: ‘Novel brain expressed gene and protein associated with bipolar disorder’, Date of Filing 17.09.02, Applicant: Janssen Pharmaceutics, Inventors: Del-Favero, J. & Van Broeckhoven, C.
• International Patent Application PCT/EP03/50290, Patent: ‘Diagnostic test for the detection of peripheral Neuropathy’, Date of Filing 08.07.03, Applicant: Interuniversity Institute for Biotechnology (VIB), Inventors: Van Broeckhoven, C., De Jonghe, P., Timmerman, V. & Verhoeven, K.
• US & CA Patent Application PCT/EP02/10667, Patent: ‘Brain expressed CAP-2 gene and protein associated with bipolar Disorder’, Date of Filing 15.01.04, Applicant: Janssen Pharmaceutica, Inventors: Del-Favero, J. & Van Broeckhoven, C.
• Published Patent WO 2004/005541, Patent: ‘Diagnostic test for the detection of peripheral Neuropathy’, Date of Filing 15.01.04, Applicant: Interuniversity Institute for Biotechnology (VIB), Inventors: Van Broeckhoven, C., De Jonghe, P., Timmerman, V. & Verhoeven, K.

GRANT REVIEWER
National Health and Medical Research Council, Australia
Fonds zur Förderung der Wissenschaflichen Forschung, Austria
Alzheimer Association, Canada
Colciencias, Colombia
Alzheimer Forschung Initiative (AFI), Germany
The Health Research Board, Ireland
The Israel Science Foundation, Israel
The Italian Ministry for University and Scientific Research, Italy
The National Research Council, Portugal
Swiss National Science Foundation, Switzerland
Internationale Stichting Alzheimer Onderzoek (ISAO), The Netherlands
Netherlands organization for Scientific Research (NWO), The Netherlands
Action Research, UK
Medical Research Council (MRC), UK
The Muscular Dystrophy Group, UK
The Welcome Trust, UK
Alzheimer Association, USA
Human Frontier Science Program

EDITORIAL BOARDS

International

American Journal of Alzheimer’s disease: Member of the Research Editorial Board
European Journal of Human Genetics: Member of the Editorial Board
Genes, Brain and Behavior: Member of the Editorial Board
Human Genetics: Member of the Editorial Board
Human Molecular Genetics: Member of the Editorial Board
Human Mutation: Communicating Editor
Neurobiology of Disease: Member of the Editorial Board
Neurodegenerative Diseases: Member of the Editorial Board
Neurogenetics: Member of the Editorial Board
NeuroMolecular Medicine: Co-Editor

National

Acta Neurologica Belgica: Member of the Advisory Board
Mediator plus ultra, Scientific Advisory Board
Neurowetenschappen: Member of the Scientific Advisory Board

 

KEY REFERENCES

Lambrechts,D., Storkebaum,E., Morimoto,M., Del-Favero,J., Desmet,F., Thijs,V., Wyns,S., Marklund,S.L., Andersson,J., van Marion,I., Al-Chalabi,A., Bornes,S., Musson,R., Hansen,V., Beckman,L., Adolfsson,R., Singh Pall,H., Prats,H., Rutgeerts,P., Awata,T., Scambler,P., Leigh,N., Lang-Lazdunski,L., Shaw,C., Moons,L., Vlietinck,R., Morrison,K.E., Robberecht,W., Van Broeckhoven,C., Collen,D., Andersen,P.M., Carmeliet,P.: VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans, and protects motor neurons against ischemic death. Nature Genetics 34(4): 383-394 (2003) (I.F.: 26.711)

Segurado,R., Detera-Wadleigh,S.D., Levinson,D.F., Lewis,C.M., Gill,M., Nurnberger,Jr, Craddock,N., DePaulo,J.R., Baron,M., Gershon,E.S., Ekholm,J., Cichon,S., Turecki,S., Claes,S., Kelsoe,J.R., Schofield,P.R., Badenhop,R.F., Morissette,J., Coon,H., Blackwood,D., Curtis,D., McInnes,L.A., Foroud,T., Edenberg,H., Reich,T., Rice,J., Goate,A., McInnis,M., McMahon,F.J., Badner,J.A., Goldin,L.R., Phil Bennett,P., Willour,V., Zandi,P., Liu,J., Gilliam,C., Juo,S-H., Berrettini,W.H., Yoshikawa,T., Peltonen,L., Lönnqvist,J., Nöthen,M.M., Schumacher,J., Windemuth,C., Rietschel,M., Propping,P., Alda,M., Grof,P., Rouleau,G.A., Del-Favero,J., Van Broeckhoven,C., Mendlewicz,J., Adolfsson,R., Spence,M.A., Luebbert,H., Adams,L.J., Donald,J.A., Mitchell,P.B., Barden,N., Shink,E., Byerley,W., Muir,W., Visscher,P., Macgregor,S., Gurling,H., Kalsi,G., McQuillan,A., Escamilla,M.A., Reus,V.I., Leon,P., Freimer,N.B., Ewald,H., Kruse,T.A., Mors,O., Radhakrishna,U., Blouin,J.-L., Antonarakis,S.E., Akarsu,N.: Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder. American Journal of Human Genetics 73(1): 49-62 (2003) (I.F.: 10.649)

Dermaut,B., Theuns,J., Sleegers,K., Hasegawa,H., Van den Broeck,M., Vennekens,K., Corsmit,E., St. George-Hyslop,P., Cruts,M., van Duijn,C.M., Van Broeckhoven,C.: The gene encoding nicastrin, a major ?-secretase component, modifies risk for familial early-onset Alzheimer's disease in a Dutch population-based sample. American Journal of Human Genetics 70: 1568-1574 (2002) (I.F.: 10.649)

Van Goethem,G., Dermaut,B., Löfgren,A., Martin,J-J., Van Broeckhoven,C.: Mutation of POLG is associated with progressive external ophthalmplegia characterized by mtDNA deletions. Nature Genetics 28: 211-212 (2001) (I.F.: 29.6)

Claes,L., Del-Favero,J., Ceulemans,B., Lagae,L., Van Broeckhoven,C., De Jonghe,P.: De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy. American Journal of Human Genetics 68: 1327-1332 (2001) (I.F.: 10.542)

Timmerman,V., De Jonghe,P., Van Broeckhoven,C.: Of giant axons and curly hair. Nature Genetics 26: 254-255 (2000) (I.F.: 30.91)

Croes,E.A., Dermaut,B., van der Cammen,T.J.M., Van Broeckhoven,C., van Duijn,C.M.: Genetic testing should not be advocated as a diagnostic tool in familial forms of dementia. American Journal of Human Genetics 67: 1033-1035 (2000) (I.F.: 10.35)

Dermaut,B., Cruts,M., Slooter,A.J.C., Van Gestel,S., De Jonghe,C., Vanderstichele,H., Vanmechelen,E., Breteler,M.M., Hofman,A., van Duijn,C.M., Van Broeckhoven,C.: The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease. The American Journal of Human Genetics 64: 290-292 (1999) (I.F.: 10.426)

Ott,A., Slooter,A.J.C., Hofman,A., van Harskamp,F., Witteman,J.C.M., Van Broeckhoven,C., van Duijn,C.M., Breteler,M.M.B.: Smoking and risk of dementia and Alzheimer’s disease in a population-based cohort study: the Rotterdam study. The Lancet 351: 1840-1843 (1998) (I.F.: 11.793)

Klaver,C.C.W., Kliffen,M., van Duijn,C.M., Hofman,A., Cruts,M., Grobbee,D.E., Van Broeckhoven,C., de Jong,P.T.V.M.: Genetic association of apolipoprotein E with age-related macular degeneration. American Journal of Human Genetics 63: 200-206 (1998) (I.F.: 10.869)

Reiter,L.T., Hastings,P.J., Nelis,E., De Jonghe,P., Van Broeckhoven,C., Lupski,J.R.: Human meiotic recombination products revealed by sequencing a hotspot for homologous strand exchange in multiple HNPP deletion patients. American Journal of Human Genetics 62: 1023-1033 (1998) (I.F.: 10.869)

Tysoe,C., Whittaker,J., Xuereb,J., Cairns,N.J., Cruts,M., Van Broeckhoven,C., Wilcock,G., Rubinsztein,D.C.: A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer’s disease. American Journal of Human genetics 62: 70-76 (1998) (I.F.: 10.869)

Nelis,E., Holmberg,B., Adolfsson,R., Holmgren,G., Van Broeckhoven,C.: PMP22 Thr(118)Met: recessive CMT1 mutation or polymorphism? Nature Genetics 15: 13-14 (1997) (I.F.: 38.856)

Hofman,A., Ott,A., Breteler,M.M.B., Bots,M.L., Slooter,A.J.C., van Harskamp,F., van Duijn,C.M., Van Broeckhoven,C., Grobbee,D.E.: Atherosclerosis, apolipoprotein E and the prevalence of dementia and Alzheimer’s disease in the Rotterdam Study. The Lancet 349: 151-154 (1997) (I.F.: 16.135)

Oruc,L., Lindblad,K., Verheyen,G.R., Ahlberg,S., Jakovljevic,M., Ivezic,S., Raeymaekers,P., Van Broeckhoven,C., Schalling,M.: CAG repeat expansion in bipolar and unipolar disorders. American Journal of Human Genetics 60: 730-732 (1997) (I.F.: 10.244)

Slooter,A.J.C., Breteler,M.M., Ott,A., Van Broeckhoven,C., van Duijn,C.M.: APOE genotyping in differential diagnosis of Alzheimer’s disease. The Lancet 348: 334 (1996) (I.F.: 17.948)

Warner,L.E., Hilz,M.J., Appel,S.H., Killian,J.M., Kolodny,E.H., Karpati,G., Carpenter,S., Watters,G.V., Wheeler,C., Witt,D., Bodell,A., Nelis,E., Van Broeckhoven,C., Lupski,J.R.: Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination. Neuron 17(3): 451-460 (1996) (I.F.: 16.953)

Van Broeckhoven
,C.: Presinilins and Alzheimer disease. Nature Genetics 11: 230-232 (1995) (I.F.: 28.543)

Benomar,A., Krols,L., Stevanin,G., Cancel,G., LeGuern,E., David,G., Ouhabi,H., Martin,J-J., Dürr,A., Zaim,M., Ravisé,N., Busque,C., Penet,C., Van Regemorter,N., Weissenbach,J., Yahyaoui,M., Chkili,T., Agid,Y., Van Broeckhoven,C., Brice,A.: The gene for autosomal dominant cerebellar ataxia with pigmentary macular dystrophy maps to chromosome 3p12-p21.1. Nature Genetics 10: 84-88 (1995) (I.F.: 28.543)

van Duijn,C., Van Broeckhoven,C.: Alzheimer's disease and the family effect. Nature Genetics 8: 115 (1994) (I.F.: 22.568)

van Duijn,C.M., de Knijff,P., Cruts,M., Wehnert,A., Havekes,L.M., Hofman,A., Van Broeckhoven,C.: Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nature Genetics 7: 74-78 (1994) (I.F.: 22.568)

Kempenaers,B., Verheyen,G.R., Van den Broeck,M., Burke,T., Van Broeckhoven,C., Dhondt,A.A.: Extra-pair paternity results from female preference for high-quality males in the blue tit. Nature 357: 494-496 (1992) (I.F.: 25.466)

Van Broeckhoven,C., Backhovens,H., Cruts,M., De Winter,G., Bruyland,M., Cras,P., Martin,J-J.: Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nature Genetics 2: 335-339 (1992) (I.F.: 22.568)

Timmerman,V., Nelis,E., Van Hul,W., Nieuwenhuijsen,B.W., Chen,K.L., Wang,S., Ben Othman,K., Cullen,B., Leach,R.J., Hanemann,C.O., De Jonghe,P., Raeymaekers,P., Van Ommen,G.J.B., Martin,J-J., Müller,H.W., Vance,J.M., Fischbeck,K.H., Van Broeckhoven,C.: The peripheral myelin protein gene PMP-22 is contained within the Charcot-Marie-Tooth disease type 1A duplication. Nature Genetics 1: 171-175 (1992) (I.F.: 22.568)

Hendriks,L., van Duijn,C.M., Cras,P., Cruts,M., Van Hul,W., van Harskamp,F., Warren,A., McInnis,M.G., Antonarakis,S.E., Martin,J-J., Hofman,A., Van Broeckhoven,C.: Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the ?-amyloid precursor protein gene. Nature Genetics 1: 218-221 (1992) (I.F.: 22.568)

Hoogendijk,J.E., Hensels,G.W., Gabreëls-Festen,A.A.W.M., Gabreëls,F.J.M., Janssen,E.A.M., De Jonghe,P., Martin,J-J., Van Broeckhoven,C., Valentijn,L.J., Baas,F., De Visser,M., Bolhuis,P.A.: De-novo mutation in hereditary motor and sensory neuropathy type I. The Lancet 339: 1081-1082 (1992) (I.F.: 17.332)

van Duijn,C.M., Hendriks,L., Cruts,M., Hardy,J.A., Hofman,A., Van Broeckhoven,C.: Amyloid precursor protein gene mutation in early-onset Alzheimer's disease. The Lancet 337: 978 (1991) (I.F.: 17.332)

St. George-Hyslop,P.H., Haines,J.L., Farrer,L.A., Polinsky,R., Van Broeckhoven,C., Goate,A., Crapper McLachlan,D.R., Orr,H., Bruni,A.C., Sorbi,S., Rainero,I., Foncin,J.-F., Pollen,D., Cantu,M., Tupler,R., Voskresenskaya,N., Mayeux,R., Growdon,J., Fried,V.A., Meyers,R.H., Nee,L., Backhovens,H., Martin,J-J., Rossor,M., Owen,M.J., Mullan,M., Percy,M.E., Karlinsky,H., Rich,S., Heston,L., Montesi,M., Mortilla,M., Nacmias,N., Gusella,J.F., Hardy,J.A.: Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature: 194-197 (1990) (I.F.: 25.466)

Van Broeckhoven,C., Haan,J., Bakker,E., Hardy,J.A., Van Hul,W., Wehnert,A., Vegter-Van der Vlis,M., Roos,R.A.C.: Amyloid ?-protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science 248: 1120-1122 (1990) (I.F.: 22.067)

Bakker,E., Van Broeckhoven,C., Bonten,E.J., van de Vooren,M.J., Veenema,H., Van Hul,W., Van Ommen,G.J.B., Vandenberghe,A., Pearson,P.L.: Germline mosaicism and Duchenne muscular dystrophy mutations. Nature : 554-556 (1987) (I.F.: 25.466)

Van Broeckhoven,C., Genthe,A.M., Vandenberghe,A., Horsthemke,B., Backhovens,H., Raeymaekers,P., Van Hul,W., Wehnert,A., Gheuens,J., Cras,P., Bruyland,M., Martin,J-J., Salbaum,M., Multhaup,G., Masters,C.L., Beyreuther,K., Gurling,H.M.D., Mullan,M.J., Holland,A., Barton,A., Irving,N., Williamson,R., Richards,S.-J., Hardy,J.: Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature : 153-155 (1987) (I.F.: 25.466)

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