From 26 to 28 September 2016, Politecnico di Torino (Turin, Italy) is hosting the 2nd UNI-SET Energy Clustering Event (ECE) on the SET-Plan Core Priority 3 “Develop and strengthen energy-efficient systems” and Additional Priority 2 “Increase safety in the use of nuclear energy”. UNI-SET is a FP7 Coordination and Support Action coordinated by the European University Association (EUA) and implemented jointly with KU Leuven, representing the universities in KIC InnoEnergy. The event in Turin seeks to stimulate discussion and the development of innovative and multidisciplinary research and education programmes through clustering activities, consortia building and knowledge sharing. The ECEs aim to mobilise the European university community to tackle the “energy challenge”, in the framework of the European Strategic Energy Technology Plan (SET-Plan) and the Energy Union. The ECE themes are based on the priorities of the SET-Plan.