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ENDOCRINE DISRUPTER RESEARCH / Homepage
BACKGROUND INFORMATION EU ACTIVITIES EU FUNDED RESEARCH PROJECTS
 

Institutional framework

EU strategy on endocrine disruption

Environment DG

       
     
 

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Completed projects

FP7  FP6  FP5  FP4


Project contract number, acronym, and duration
Project title
Research Team
Focus
Web page and documents
fp6 logo FP7 projects

ENRIECO
(2009-2011)
enrieco

Environmental health risks in European birth cohorts
(Coordination and support action)

Participating laboratories:
8 (ES, FR, NL, DE, EL, SE, DK)
Coordinator:
Prof. Mark Nieuwenhuijsen
Fundacio Centre de Recerca en Epidemiologia Ambiental (CREAL)
Barcelona, Spain
Mnieuwenhuijsen(at)creal.cat

The overall aim was to advance the knowledge on specific environment and health causal relationships in pregnancy and birth cohorts by providing support to exploitation of the wealth of data generated by past or ongoing studies funded by the EC and national programmes     

Website

Final activity report summary 
  PDF icon 55 KB

REEF
(2008-2012)
reef

Reproductive effects of environmental chemicals in females
(Small or medium-scale focused research project) 

Participating laboratories:
6 (UK, FR, DE, IT)
Coordinator:
Prof. Paul Fowler Centre for Reproductive Endocrinology & Medicine Institute of Medical Sciences Division of Applied Medicine
University of Aberdeen
Aberdeen, Scotland
p.a.fowler(at)abdn.ac.uk

Provision of a real-life model for human exposure, a long-lived mono-ovulating species, the sheep, with a pattern of gestational development similar to humans, is used. They were exposed long-term to a broad range of endocrine disrupters at low/environmental concentrations. The focus was on reproductive development in females.    

Website

Final activity report summary 
  PDF icon 122 KB

fp6 logo FP6 projects
Project focused on mechanisms of endocrine disruption and toxicology

ATHON
(2006-2010)
qsq

Assessing the toxicity and hazard of non-dioxin-like PCBs present in food
(Specific Targeted Research Project)

Participating laboratories:
16 (SE, BE, NL, CZ, ES, FI, DE, IT, NO, UK, CA, JP)
Coordinator:
Prof. Helen Håkansson
Institute of Environmental Medicine
Karolinska Institutet
Stockholm, Sweden
helen.hakansson(at)imm.ki. se

The major objectives are to:
(i) establish experimental in vivo and in vitro models for studies of non-dioxin-like PCBs (NDL-PCBs); and (ii) provide toxicokinetic data, toxicity profiles, a new classification strategy for NDL-PCB congeners based on effect biomarker information, and an up-to-date compilation and evaluation of toxicological effect and exposure data on NDL-PCBs and PCB metabolites

Website

Final activity report summary 
  PDF icon 163 KB

CASCADE
(2004-2009)
sdf

Chemicals as contaminants in the food chain: a NoE for research, risk assessment and education
(Network of excellence)

Participating laboratories:
18 (SE, DE, FR, ES, FI, HU, IT, NL)
Coordinator:
Prof. Jan-Åke Gustafsson Karolinska Institutet Department of Biosciences at Novum
Huddinge, Sweden
jan-ake.gustafsson(at)mednut.ki.se
Vice-coordinator:
Dr Ingemar Pongratz
ingemar.pongratz(at)biosci.ki. se

Network of Excellence, to structure European research in the field of health risks of exposure to chemicals via food. Focus on chemical residues that act via and/or interfere with cellular regulation at the level of nuclear receptors.

Website

Final activity report summary 
  PDF icon 1.7 MB

Projects focused on improving risk assessment methods and tools

CAESAR
(2005-2009)

Computer assisted evaluation of substances according to regulations (Specific targeted research project)

Participating laboratories:
9 (IT, UK, FR, DE, SI, NL)
Coordinator:
Dr Emilio Benfenati
Istituto di Ricerche Farmacologiche "Mario Negri"
Milan, Italy
benfenati(at)marionegri.it

Production of (Q)SAR models for the prediction of the toxicity of chemical substances. Designed to be used for regulatory purposes, especially for REACH.  

 

Website

Final activity report summary 
  PDF icon 193 KB

ESBIO
(2005-2008)

 

Development of a coherent approach to human biomonitoring in Europe (Coordination action)

Participating laboratories:
14 (DE, BE, PL, PT, DK, FR, NL, CY, LX, HR, IT)
Coordinator:
Dr. Reinhard Joas
BiPRO GmbH
Münich, Germany
reinhard.joas(at)bipro.de

ESBIO aimed at developing a coordinated approach for human biomonitoring with focus on children in Europe, in line with Action 3 of the European Environment and Health Action Plan.  

Website

Final activity report summary 
  PDF icon 1.1 MB

NOMIRACLE
(2004-2009)
No-Miracle logo

Novel methods for integrated risk assessment of cumulative stressors in the environment (Integrated project)

Participating laboratories:
38 (DK, UK, DE, NL, IT, CZ, PL, PT, BE, AT, FI, LT, CH, SE, ES, BG, FR)
Coordinator:
Dr. Hans Løkke
National Environmental Research Institute
Roskilde, Denmark
hlo(at)dmu.dk

Development of methods for assessing the cumulative risks from combined exposures to multiple stressors including from complex mixtures of chemical, physical, and biological agents

Website

Final report 
  PDF icon 333 KB

NORMAN
(2005-2008)
Norman logo

Network of reference laboratories for monitoring of emerging environmental pollutant
(Coordination action)

Participating laboratories:
17 (FR, NL, DE, ES, SL, NO, SE, UK, SK, IT)
Coordinator:
Dr Valeria Dulio
Institut National de l’Environnement Industriel et des Risques (INERIS)
Verneuil-en-Halatte, France
valeria.dulio(a)ineris.fr

The main aim was to create a network of reference laboratories and related organisations in order to improve the exchange of information and data on emerging environmental contaminants, and to encourage the validation and harmonisation of common measurement methods and monitoring tools

Webpage

Final activity report summary 
  PDF icon 121 KB

SAFE FOODS
(2004-2008)

Promoting food safety through a new integrated risk analysis approach for foods
(Integrated Project)

Participating laboratories:
33 (NL, UK, DE, FI, PL, IT, IE,
LV, HU, CH, SE, DK, CZ, EL,
BE, South Africa, China)
Coordinator:
Dr. H.A. Kuiper & Dr. H.J.P.
Marvin
RIKILT – Institute of Food Safety
Wageningen, The Netherlands
Harry.Kuiper(at)WUR.nl

Improvement of risk assessment methods and risk analysis practices for foods produced by different production practices (high or low input systems) and with different breeding technologies (traditional, molecular, genetic modification). One task: Quantitative risk assessment of combined exposure to food contaminants and natural toxins

Website

Final activity report summary 
  PDF icon 1.8 MB

Projects focused on neurodevelopmental effects

DEVNERTOX
(2003-2006)
Devnertox logo

Toxic threats to the developing nervous system: in vivo and in vitro studies on the effects of mixture of neurotoxic substances potentially contaminating food
(Specific targeted research project)

Participating laboratories:
9 (SE, IT, BE, IE, PL, ES)
Coordinator:
Prof Sandra Ceccatelli
Institute of Environmental Medicine
Division of Toxicology and Neurotoxicology
Karolinska Institutet Stockholm, Sweden
Sandra.Ceccatelli(at)imm.ki.se

Development of experimental models to improve predictive toxicity testing and mechanism-based risk assessment for neurotoxic food contaminants. Effects of mixtures of persistent pollutants (PCBs, methylmercury) on the developing nervous system.

Website

Final activity report summary  
  PDF icon 725 KB  

Projects focused on reproductive health outcomes

F&F
(2004-2007)
F&F logo

Pharmaceutical products in the environment: development and employment of novel methods for assessing their origin, fate and effects on human fecundity (Specific targeted research project)

Participating laboratories:
8 (IL, DK, FR, NL, UK, AT)
Coordinator:
Dr Haim Schlesinger
Coordinator
Analyst Research Laboratory Ltd.
Rehovot, Israel
analysthaim(at)012.net.il

Identify pharmaceutical products that may affect human fecundity; mechanisms involved. Develop diagnostic methods and high throughput screening assays for monitoring. Evaluate environmental, food and population exposure to high risk PPs. 

Website

Final activity report summary 
  PDF icon 394 KB
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PIONEER
(2005-2008)

Puberty onset - influence of environmental and endogenous regulators (Specific targeted research project)

Participating laboratories
11 (FI, SE, IT, FR, HU, UK, DE, PK)
Coordinator:
Prof. Sari Mäkelä
University of Turku
Turku, Finland
sarmak(at)utu.fi

Major objectives:
(i) obtain updated data on the age of puberty onset in different regions of Europe;
(ii) identify genetic and nutritional factors involved in the regulation of the onset of puberty;
(iii) develop novel experimental test models  

Website

Final activity report summary 
  PDF icon 272 KB
 

REPROTECT
(2005-2009)

Development of a novel approach in hazard and risk assessment of reproductive toxicity by a combination and application in vitro, tissue and sensor technologies (Integrated project)

Participating laboratories:
26 (DE, NL, BE, IT, UK, FR, SE, BG, AT, DK)
Coordinator:
Dr Michael Schwartz
University of Tübingen Institut für Pharmakologie und Toxikologie
Tübingen,Germany
michaël.schwarz(at)uni-tuebingen.de

To develop validated alternative test methods for safety toxicology of drugs, chemicals and cosmetics. Focus on systemic toxicity. Development of a conceptual framework in the area of reproductive toxicity.
Four elements included:
(i) technological development of in vitro;
(ii) in silico and sensor technologies;
(iii) the strategical development of a conceptual framework;
(iv) the dissemination and implementation activities

Website

Final activity report summary 
  PDF icon 129 KB

Project focused on environmental causes of cancer

NEWGENERIS
(2006-2011)

Newborns and genotoxic exposure risks: Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks (Integrated Project)

Participating laboratories:
25 (NL, GR, ES, UK, DK, SE, BE, DE, NO, IT, FI, HU, HR, SK, FR, CH)
Coordinator:
Prof. Jos Kleinjans
Department of Health Risk Analysis and Toxicology
Maastricht University
Maastricht, The Netherlands.
j.kleinjans(at)grat.unimaas.nl

Study whether and to what extent parental exposure to dietary genotoxicants and immunotoxicants induces molecular events in the foetus which may induce cancer and immune disorders in later childhood. Some endocrine related mechanisms were covered.

Website

Final activity report summary 
  PDF icon 120 KB

Projects carrying out reviews of state-of-the-art

HENVINET
(2006-2010)

Health and environment network (Coordination action)

Participating laboratories:
25 (NL, GR, ES, UK, DK, SE, BE, DE, NO, IT, FI, HU, HR, SK, FR, CH)
Coordinator:
Dr Inga Fløisand
Norwegian Institute for Air Research
Integrated Environmental Systems
Kjeller, Norway
ifl(at)nilu.no

HENVINET will review, exploit and disseminate knowledge on environmental health issues based on research and practices, for wider use by relevant stakeholders. Further, it will lead to validation of tools and results with emphasis on the four priority health diseases of the European Environment and Health Action Plan (EHAP) 2004-2010, and will provide structured information overview that may be utilised by other actors relevant to Environment and Health Strategy.

Website

Final activity report summary 
  PDF icon 109 KB

fp5 logoFP5 projects
Projects focused on aquatic wildlife

ACE
(2001-2003)
ACE Logo

Analysing combination effects of mixtures of estrogenic chemicals in marine and freshwater organisms (Shared-cost research project)

Participating laboratories:
7 (UK, DE, PT, NL, IT)
Coordinator:
Prof. John Sumpter
Brunel University
Department of Biology and Biochemistry
Uxbridge, United Kingdom
john.sumpter(at)brunel.ac.uk

Hazard assessment of EDC in aquatic systems by analysing and assessing the effects of multi-component mixtures of xenoestrogens on biological systems, ranging from the sub-cellular level to populations of fish

Results on Europa website 
  PDF icon 291 KB
Final report summary 
  PDF icon 57 KB

BEEP
(2001-2004)
ACE Logo

Biological effects of environmental pollution in marine coastal ecosystems (Shared-cost research project)

Participating laboratories:
30 (FR, IT, FI, NO, UK, ES, DE, SE, LT, EL, PL, IL)
Coordinator:
Dr Philippe Garrigues
Laboratoire de Physico-Toxicochimie des Systèmes Naturels  
Université Bordeaux I,
Talence, France
p.garrigues(at)lptc.u-bordeaux.fr

Study of biological markers under chemical stress in marine organisms distributed along the North Atlantic, Baltic and Mediterranean sea coasts.

Results on Europa website 
  PDF icon 310 KB
Final report summary 
  PDF icon 2.6 MB

BIOCET
(2000-2003)

Bioaccumulation of persistent organic pollutants in small cetaceans in European waters: transport pathways and impact on reproduction (Shared-cost research project)

Participating laboratories:
7 (UK, NL, ES, FR, IE)
Coordinator:
Dr Graham J. Pierce
University of Aberdeen
Department of Zoology   School of Biological Sciences
Aberdeen, United Kingdom
g.j.pierce(at)abdn.ac.uk

Quantification and modelling of the process and time course of bioaccumulation of persistent organic pollutants in small cetaceans in Atlantic waters

Website

Results on Europa website 
  PDF icon 323 KB
Final report summary 
  PDF icon 47 KB

COMPRENDO (2002-2005)
Comprendo Logo

Comparative research on endocrine disrupters – phylogenetic approach and common principles focusing on androgenic/
antiandrogenic compounds (Shared-cost research project)

Participating laboratories:
14 (DE, UK, IT, SE, DK, FR, ES, EL, PL)
Coordinator:
Dr Ulrike Schulte-Oehlmann
Johann Wolfgang Goethe-University Frankfurt
Zoological Institute Department of Ecology & Evolution
Frankfurt am Main, Germany
schulte-oehlmann(at)zoology.
uni-frankfurt.de

Improvement of the understanding of the effects of EDCs on aquatic wildlife and humans, focusing on androgenic and antiandrogenic compounds

Website

Results on Europa website 
  PDF icon 291 KB
Final report summary 
  PDF icon 28 KB

FAMIZ
(2000-2003)

Food-web uptake of persistent organic pollutants in the Arctic-marginal ice zone of the Barents sea

Participating laboratories:
3 (SE, NL, DE)
Coordinator:
Prof. Örjan Gustafsson
Stockholm University
Institute of Applied Environmental Research
Stockholm, Sweden
orjan.gustafsson(at)itm.su.se

Accumulation of persistent organic pollutants in Arctic food webs

Website

Final report summary 
  PDF icon 33 KB -

Project focused on bone effect

BONETOX
(2003-2006)Bonetox Logo

Bone development and homeostasis – critical targets in toxicology. Research to support test-method development and human-health risk assessment for dioxins and other endocrine-disrupting compounds in the food chain (Shared-cost research project)

Participating laboratories:
9 (SE, DE, FR, FI, US)
Coordinator:
Prof. Helen Håkansson  Institute of Environmental Medicine
Karolinska Institutet
Stockholm, Sweden
helen.hakansson(at)imm.ki.se

Clarification of the mechanisms behind osteoporosis and structural malformations induced by EDCs in food through interactions with components of the nuclear receptor signalling pathways and other cell regulatory systems 

Website

Results on Europa website 
  PDF icon 320 KB
Final report summary  
  PDF icon 428 KB

Projects focused on multi-organ effects of endocrine disrupting chemicals and risk assessment

COMPARE   (2001-2003)
Compare Logo

Comparison of exposure-effect pathways to improve the assessment of human-health risks of complex environmental mixtures of organohalogens (Shared-cost research project)

Participating laboratories:
7 (NL, DE, SE, IE)
Coordinator:
Prof. Abraham Brouwer
Institute for Environmental Studies
Vrije Universiteit
Amsterdam, The Netherlands
bram.brouwer(at)ivm.vu.nl

Early-life stage exposure and long-term effects of organohalogens in humans, rodents, and birds  

Results on Europa website 
  PDF icon 265 KB
Final report summary 
  PDF icon 266 KB

DIOXIN RISK ASSESSMENT
(2000-2003)

Comprehensive risk analysis of dioxins: development of methodology to assess genetic susceptibility to developmental disturbances and cancer

Participating laboratories:
6 (FI, SE, LT, IT)
Coordinator:
Prof. Jouko Tuomisto
National Public Health Institute
Division of Environmental Health
Kuopio, Finland
jouko.tuomisto(at)ktl.fi

Human health implications of dioxins (cancer and developmental effects)

Results on Europa website 
  PDF icon 300 KB

Final report summary 
  PDF icon 164 KB

EDEN
(2002-2006)
Eden Logo

Endocrine disrupters: exploring novel endpoints, exposure, low-dose and mixture effects in humans, aquatic wildlife and laboratory animals  (Shared-cost research project)

Participating laboratories:
22 (UK, DK, FI, NL, SE, ES, CH, DE, FR, BE)
Coordinator:
Dr Andreas Kortenkamp
University of London,  The School of Pharmacy Centre for Toxicology
London, United Kingdom
Andreas.kortenkamp(at)ulsop.ac.uk

Low-dose and mixture effects of EDCs; mechanisms underlying the action of EDCs; wildlife and human hazard assessment; human reproductive health

Results on Europa website 
  PDF icon 297 KB
Final report summary 
  PDF icon 1.1 MB

EURISKED
(2002-2006)
Eurisked Logo

Multi-organic risk assessment of selected endocrine disrupters
(Shared-cost research project)

Participating laboratories:
10 (DE, FI, UK, PL, CH, ES, AR)
Coordinator:
Prof. Wolfgang Wuttke
University of Göttingen   Faculty of Medicine
Division of Clinical and Experimental Endocrinology
Göttingen, Germany
ufkendo(at)med.uni-
goettingen.de

Risk assessment of oestrogen, androgen, progestin, glucocorticoid or thyroid hormone-receptive organs (neuroendocrine brain, the cardiovascular, skeletal or urogenital system during development and adult life) following exposure to EDC in cosmetics or pesticides/ fungicides.

Website

Results on Europa website 
  PDF icon 277 KB
Final report summary 
  PDF icon 29 KB

ENDOMET
(2003-2005)
Endomet Logo

Dysregulation of endogenous steroid metabolism potentially alters neuronal and reproductive system development: effects of environmental plasticisers (Shared-cost research project)

Participating laboratories:
6 (UK, DE, DK, SK)
Coordinator:
Dr. Rosemary H. Waring
School of Biosciences
University of Birmingham
Birmingham, United Kingdom
r.h.waring(at)bham.ac.uk

Low-level and mixture effects of EDCs (plasticisers) in food and surgical tubing on reproduction and other systems under steroid hormone control 

Website

Results on Europa website 
  PDF icon 314 KB
Final report summary 
  PDF icon 86 KB

ESTROGENS AND DISEASE
(2001-2004)

The impact of developmental exposure to weak (environmental) estrogens on the incidence of diseases in target organs later in life (Shared-cost research project)

Participating laboratories:
5 (NL, SE, DK, DE)
Coordinator:
Dr Paul van der Saag (retired)
Dr Anja van de Stolpe
Netherlands Institute for Developmental Biology
Utrecht, The Netherlands
anja(at)niob.knaw.nl

Developmental effects of exposure to oestrogens in the prostate, testis, mammary gland, brain, and the ovaries of the offspring (mice)

Website
Results on Europa website 
  PDF icon 306 KB
Final report summary 
  PDF icon 59 KB

FIRE
(2002-2006)
Fire Logo

Risk assessment of brominated flame retardants as suspected endocrine-disrupters for human and wildlife health (Shared-cost research project)

Participating laboratories:
19 (NL, NO, SE, UK, BE, DE, CZ)
Coordinator:
Dr. Antoon Opperhuizen
National Institute for Public Health and the Environment (RIVM)
Bilthoven, The Netherlands
a.opperhuizen(at)rivm.nl

Risk assessment of brominated flame retardants for human health and wildlife

Website
Results on Europa website 
  PDF icon 301 KB
Final report summary  
  PDF icon 160 KB

PCBRISK
(2001-2003)
PC-Brisk Logo

Evaluating human-health risk from low-dose and long-term PCB exposure (Shared-cost research project)

Participating laboratories:
8 (SK, SE, CZ, DE, NL, UK)
Coordinator:
Prof. Tomáš Trnovec
Institute of Preventive and Clinical Medicine 
Bratislava, Slovakia
trnovec(at)upkm.sk

Assessment of endocrine-disrupting effects (thyroid, gonads, reproduction, neuroendocine system) and immunomodulatory effects of exposure to PCBs in humans in a heavily polluted area in Slovakia

Results on Europa website 
  PDF icon 314 KB
Final report summary 
  PDF icon 73 KB

Projects focused on neurodevelopmental effects

ANEMONE
(2002-2004)
Anemone Logo

Assessment of neurobehavioral endpoints and markers of neurotoxicants exposures (Shared-cost research project)

Participating laboratories:
5 (DK, SE, IT, DE)
Coordinator:
Prof. Philippe Grandjean
Institute of Public Health
Department of Environmental Medicine
Odense, Denmark
pgrandjean(at)health.sdu.dk

Exposure to organohalogens through seafood and adverse effects on cognitive functions in children in the Faeroe Isles  

Website
Results on Europa website 
  PDF icon 307 KB
Final report summary 
  PDF icon 54 KB

PBDE-NTOX
(2000-2003)

Developmental neurotoxicity of polybrominated diphenylether: mechanisms and effects  (Shared-cost research project)

Participating laboratories:
5 (DE, CH, IT, SE, ES)
Coordinator:
Prof. Herbert Wiegand
Heinrich-Heine University Düsseldorf Medical Institute of Environmental Hygiene,
Düsseldorf, Germany
wiegand(at)uni-duesseldorf.de

Elucidation of effects of developmental exposure of animals to flame retardants (PBDE) on central nervous system 

Results on Europa website 
  PDF icon 275 KB
Final report summary 
  PDF icon 60 KB

SENSPESTI
(2003-2005)

Tissue engineering of living biosensors to evaluate risks for health by pesticides affecting the cholinergic neurotransmitter system  (Shared-cost research project)

Participating laboratories:
7 (IT, UK, HU, DE)
Coordinator:
Prof. Carla Falugi
University of Genoa
Department of Experimental, Environmental and Applied Biology
Genoa, Italy
falugi(at)unige.it

Investigations on the molecular and functional responses of living cells and developing embryos of simple organisms to cholinergic pesticides, using appropriate cell and tissue models. One focus was on neurotoxic pesticides influencing neuroendocrine activity of epiphysis as well as gametogenesis and sperm behaviour.

Website
Results on Europa website 
  PDF icon 281 KB

Projects focused on neuroendocrine system
SENSPESTI
(2003-2005)
Tissue engineering of living biosensors to evaluate risks for health by pesticides affecting the cholinergic neurotransmitter system Participating laboratories:
7 (IT, GB, HU, DE)
Prof. Carla FALUGI
University of Genova
Dipart. Biologia Sperimentale, Ambientale, Applicata (DI.BI.S.A.A.)
Viale Benedetto XV, N°5
I-16132 Genova, (Italy)
Tel 39-010-3538055; FAX 39-010-353 8047
falugi@unige.it
Investigations on the molecular and functional responses of living cells and developing embryos of simple organisms to cholinergic pesticides, using appropriate cell and tissue models. One of the objectives is to focus on neurotoxic pesticides influencing neuroendocrine activity of epiphysis as well as gametogenesis and sperm behaviour.

Website
Summary 
  PDF icon 272 KB

Projects focused on phytoestrogens

PHYTO- PREVENT
(2001-2004)
PhytoPrevent Logo

The role of dietary phytoestrogens in the prevention of breast and prostate cancer

Participating laboratories:
9 (UK, FI, SE, EL, DE, DK, NL)
Coordinator:
Prof. Ian Rowland
University of Ulster Northern Ireland Centre for Diet and Health 
School of Biomedical Sciences
Coleraine, United Kingdom
i.rowland(at)ulster.ac.uk

Evaluation of phytoestrogens in prevention of prostate and breast cancer 

Final report summary 
  PDF icon 72 KB -

QLK1-CT-2000-00431
PHYTOS
(2001-2004)

Phytos Logo

The prevention of osteoporosis by nutritional phytoestrogens

Participating laboratories:
9 (IT, FR, NL, GB, FI, BE)
Coordinator:
Prof. Francesco Branca
INRAN, Human Nutrition Unit
Via Ardeatina, 546
176 Rome, Italy
Tel: +39 06 5032421
Fax: +39 06 5031592
f.branca@agora.it

Effect of soy isoflavones on bone density and metabolism in Caucasian postmenopausal women

Website

3rd year progress report 
  PDF icon 111 KB

Projects focused on reproductive health outcomes

ENDISRUPT
(2001-2004)

Identification of critical rat testicular genes altered after fetal androgenic disruption by flutamide: use of DNA microarray (Shared-cost research project)

Participating laboratories:
4 (FR, NL, FI)
Coordinator:
Dr Mohamed Benahmed
Faculté de Médecine Lyon-sud
Lyon, France
benahmed(at)lsgrisn1.
univ-lyon1.fr

Use of DNA microarray approach to assess endocrine disrupting effects of flutamide on testicular development and function 

Results on Europa website 
  PDF icon 321 KB
Final report summary 
  PDF icon 43 KB

ENVIRON. REPROD. HEALTH
(2000-2005)

Increasing incidence of human male reproductive health disorders in relation to environmental effects on growth- and sex steroid-induced alterations in programmed development (Shared-cost research project)

Participating laboratories:   12 (DK, FI, UK, FR, ES, US, JP, EE, LT, LV)
Coordinator:
Prof. Niels E. Skakkebæk
University of Copenhagen  Department of Growth and Reproduction, Rigshospitalet Copenhagen, Denmark
nes(at)rh.dk

  Participating laboratories:
Male reproductive health in Europe 

Results on Europa website 
  PDF icon 297 KB
Final report summary 
  PDF icon 195 KB

EXPORED
(2002-2004)

Outcome relationships in male urogenital malformations with special reference to endocrine disrupters (Shared-cost research project)

Participating laboratories:
4 (DK, FI, DE)
Coordinator:   Prof. Niels E. Skakkebæk
University of Copenhagen  Department of Growth and Reproduction Rigshospitalet Copenhagen, Denmark
nes@rh.dk

Relationship of foetal exposure to endocrine disrupting chemicals and urogenital disorders of boys 

Results on Europa website 
  PDF icon 294 KB
Final report summary 
  PDF icon 81 KB

GENDISRUPT
(2005)
Gendisrupt  Logo

Genetic markers and susceptibility to the effects of endocrine disruptors during mammalian testis development (Shared-cost research project)

Participating laboratories:
5 (ES, IT, UK, NL)
Coordinator:
Dr. Jesús del Mazo
Centro de Investigaciones Biológicas
CSIC
Madrid, Spain
jdelmazo(at)cib.csic.es

Identification of genes representative of the action of endocrine disrupters  over different cell types in testis and discovery of polymorphic genes potentially involved in susceptibility to endocrine disrupting chemicals  

Results on Europa website
Final report summary 
  PDF icon 74 KB

INUENDO
(2002-2005)
Inuendo  Logo

Biopersistent organochlorines in diet and human fertility. Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (Shared-cost research project)

Participating laboratories:
7 (DK, SE, IT, PL, UA)
Coordinator:
Dr. Jens Peter Bonde
Aarhus University Hospital
Department of Occupational Medicine
Aarhus, Denmark
pbon(at)akh.dk

Impact of dietary biopersistent organochlorides on fertility of Inuit and European populations  

Website
Results on Europa website 
  PDF icon 257 KB
Final report summary 
  PDF icon 75 KB

Projects focused on testing methods and technology development

EASYRING
(2003-2005)
Easyring Logo

Environmental-agent susceptibility assessment utilising existing and novel biomarkers as rapid non-invasive testing methods (Shared-cost research project)

Participating laboratories:
8 (IT, NO, DE, BE, UK)
Coordinator:
Dr. Alberta Mandich
Università di Genova Dipartimento di Biologia Sperimentale, Ambientale ed Applicata   Genoa, Italy
mandich@unige.it

Development of biomarkers for EDs and in vitro test systems; investigate short/long-term and low-level exposure effects of EDC mixtures in low vertebrates and small mammals 

Website
Results on Europa website 
  PDF icon 307 KB
Final report summary 
  PDF icon 42 KB

EDERA
(2003-2005)
Edera Logo

Development and implementation of new in vivo and in vitro systems for the characterisation of endocrine disruptors (Shared-cost research project)

Participating laboratories:
5 (IT, CH, SE, IE)
Coordinator:
Dr Adriana Maggi
University of Milan Milan, Italy
Adriana.Maggi(at)unimi.it

Development of in vivo and in vitro testing systems to measure effects of low concentrations of EDC 

Website
Results on Europa website 
  PDF icon 304 KB
Final report summary 
  PDF icon 82 KB
Final report summary 
  PDF icon 18 KB

MENDOS
(2003-2005)
Mendos Logo

Biomimetic optical sensors for environmental endocrine disruptor screening (Shared-cost research project)

Participating laboratories:
11 (AT, US, DE, FR, CZ, HU, IL, SE, BE)
Coordinator:
Dr Michael Jakusch 
ARC Seibersdorf research GmbH
Seibersdorf, Austria
michael.jakusch(at)arcs.ac.at

Development of artificial receptor-based optical sensor systems and their application for assessing and screening EDCs  

Results on Europa website 
  PDF icon 282 KB
Final report summary 
  PDF icon 134 KB

POSEIDON
(2001-2004)
ACE Logo

Assessment of technologies for the removal of pharmaceuticals and personal-care products in sewage and drinking water facilities to improve the indirect potable water reuse (Shared-cost research project)

Participating laboratories:
8 (DE, CH, FI, AT, ES, PL, FR)
Coordinator:
Dr. Thomas Ternes
Bundesanstalt für Gewässerkunde
Koblenz, Germany
ternes@bafg.de

Behaviour of pharmaceuticals and personal care products (some EDC) in various water bodies  

Final report summary 
  PDF icon 176 KB -

FP4 projects  
Projects focused on aquatic wildlife and birds

ENV4-CT-97-0468
POP-REP
(1997-2000)

Effects of lipophilic persistent organic pollutants (POPS) on the reproduction of egg-laying organisms

Participating laboratories:
4 (SE, NL, NO, FI)
Coordinator:
Prof. Dag Broman
Stockholms Universitet
Dept Institute of Applied Environmental Research
Englundavägan 5
106 91 Stockholm, Sweden
Tel: + 46 8 164018  
Fax.: + 46 8 6747199
dag.broman@zoologi.su.se

Exposure of salmon and guillemot to persistent organic pollutants

Project final report 
  PDF icon 24 KB

ENV4-CT-97-0509
IDEA
(1997-2000)

Identification of endocrine-disrupting effects in aquatic organisms

Participating laboratories:
5 (DE, BE, GB)
Coordinator:
Prof. Helmut Segner
University of Bern
Institute of Animal Pathology, Centre for Fish and Wildlife Health
Laenggass-Str. 122
3012 Bern, Switzerland
Tel: +41 31 6312441  
Fax: +41 31 6312611
helmut.segner@itpa.unibe.ch

Effects of oestrogens on zebrafish and invertebrates

Project final report 
  PDF icon 17 KB

ENV4-CT-97-0567
EES AND FISH REPRODUCTION
1997-1999

Environmental estrogens (EEs) and the neuro-endocrine regulation of reproduction in fish

Participating laboratories:
3 (NL, IL, GB)
Coordinator:
Dr. Rüdiger Schulz
Rijksuniversiteit Utrecht
Vakgroep Experimentele Dierkunde – Faculteit Biologie – Beheercluster
Organismale Zoölogie
Onderzoeksgroep voor Vergelijkende Endocrinologie
Padualaan 8
3584 CH Utrecht, The Netherlands
Tel: +31 30 253 3046 
Fax: +31 30 253 2837
r.w.schulz@biol.ruu.nl

Effects of environmental oestrogens (model: 4-nonylphenol) on reproduction of freshwater fish

Project final report 
  PDF icon 21 KB

ENV4-CT-98-0798
COMPREHEND
2000-2002

Community programme of research on endocrine disrupters  and environmental hormones

Participating laboratories:
13 (GB, NL, CH, FR, NO, SE, FI)
Coordinator:
Prof. Alan D. Pickering
NERC Centre for Ecology and Hydrology
Windermere Laboratory
Far Sawry, Ambleside,
Cumbria LA22 OLP, United Kingdom
Tel: + 44 1539 442468 
Fax: + 44 1539 446914
adp@ceh.ac.uk

Endocrine disruption in the aquatic environments in Europe, consequent to effluent discharge, in particular oestrogenic activity of both domestic and industrial wastewater effluents and their impacts on fish.

Project final report 
  PDF icon 44 KB

FAIR-CT-97-3755
No acronym
1998-2000

Fish sperm viability as an indicator of environmental pollution

Participating laboratories: 2 (GB, BE)
Coordinator:
Dr. David E. Kime
University of Sheffield
Dept of Animal and Plant Science
PO Box 601
S10 2TN Sheffield, United Kingdom
Tel: + 44 114 2224316  
Fax: + 44 114 2220002
d.kime@sheffield.ac.uk

Effect of environmental pollution (polluted rivers) on fish sperm quality and reproductive health

Project final report 
  PDF icon 26 KB

Projects focused on effects of EDC in humans/mammals

ENV4-CT-96-0336
DIOXIN RISK ASSESSMENT
1996-1999

Risks of environmental dioxins: linking epidemiology with toxicity studies to strengthen accurate risk assessment

Participating laboratories:
5 (FI, SE, DE)
Coordinator:
Prof. Jouko Tuomisto
National Public Health Institute
Dept Division of Environmental Health
Neulaniementie 4
70701 Kuopio, Finland
Tel: + 49 21 131 90910  
Fax: + 49 21 131 90910
jouko.tuomisto@ktl.fi

Effect of dioxins on tumour promotion in rats, soft tissue sarcoma in humans, and tooth development in children

Project final report 
  PDF icon 62 KB

ENV4-CT-96-0170
RENCO
(1996-1999)

Assessment of human risk for adverse effects of endocrine-active environmental organohalogen contaminants

Participating laboratories:
6 (SE, NL, GB)
Coordinator:
Prof. Åke Bergman
Stockholms Universitet
Department of Environment and Chemistry
Lilla Frescativägen 7
10691 Stockholm, Sweden
Tel: +46 8 16 3997
Fax: +46 8 15 2561
alb@mk.su.se

Risk assessment for adverse health effects, with special emphasis on developmental effects in human infants, due to environmental exposure organohalogens, especially PCBs.

Project final report 
  PDF icon 46 KB

ENV4-CT-96-0209
No acronym
(1996-1999)

Environmental PCB-exposure and developmental deficit: neurobehavioural functions beyond the age of 18 months until school age

Participating laboratories:
5 (DE, NL, DK)
Coordinator:
Prof. Gerhard Winneke
Neuro- und Verhaltenstoxikologie
Medizinisches Institut fur Umwelthygiene
a.d Heinrich-Heine-Universitat Düsseldorf
P.O. Box 103751
40225 Düsseldorf, Germany
Tel: +49 211 3389291 
Fax: +49 211 3389331
gerhard.winneke@uni-duesseldorf.de

Effect of PCBs on children, with particular reference to neurobehavioural functioning and development

Project final report 
  PDF icon 18 KB

ENV4-CT-96-0240
No acronym
(1996-1999)

Environmental halogenated aromatic hydrocarbons and estrogens; mechanism of action, interactions and test-system development

Participating laboratories:
6 (NL, SE, DE, GB, FI)
Coordinator:
Prof. Bart van der Burg
Nederlands Instituut voor Ontwikkelingsbiologie
Hubrecht Laboratorium
Uppsalalaan 8
3584 CT Utrecht, The Netherlands
Tel: +31-30 2121923   
Fax: +31-30 2516464
bvdb@hl99.niob.knaw.nl

Elucidating mechanisms of action of oestrogens and developing novel assays for oestrogenic activity

Project final report 
  PDF icon 16 KB

FAIR-CT-98-04071
No acronym
2000-2002

Impact of endocrine disrupting agents in food on reproductive health in farm animals

Participating laboratories:
10 (DE, NL, IE, GB, IT, NO, FR)
Coordinator:
Prof. Bernd Fischer
Martin Luther University Halle – Wittenberg
Dept of Anatomy and Cell Biology
Grosse Steinstrasse 52
06097 Halle Saale, Germany
Tel: + 49 34 55571701   
Fax : + 49 34 55571700
bernd.fischer@medizin.uni-halle.de

Impact of EDC on reproductive health of farm animals

Project final report 
  PDF icon 28 KB

BMH4-CT-96-0314
No acronym
1996-1998

Male reproductive health and environmental chemicals

Participating laboratories:
6 (DK, FI, FR, GB)
Coordinator:
Prof. N. Skakkebaek
Dept of Growth and Reproduction, Copenhagen University Hospital
Rigshospitalet
Blegdamsvej 9
2100 Copenhagen, Denmark
Tel: + 45 35455087   
Fax: + 45 3545 6054
nes@rh.dk

Male reproductive health in Europe: trends and potential causes

Project final report 
  PDF icon 23 KB

Other projects

FAIR-CT-97-3827
No acronym
1998-2000

Impacts of marine xenobiotics on European commercial fish – molecular effects and population responses

Participating laboratories:
11 (GB, NO, ES, SE, DE, PT)
Coordinator:
Dr. Andrew John Lawrence
University of Hull
Dept of Biological Sciences
Cottingham Road
Hull HU6 7RX , United Kingdom
Tel: + 44 1482 465398  
Fax. : + 44 1482 465458
a.j.lawrence@appbiol.hull.ac.uk

Synthesis of the literature on the impacts of xenobiotics in commercial fish; development of a conceptual model to evaluate and assess the consequences of low-level pollution exposure on population and yield

Project final report 
  PDF icon 34 KB

ENV4-CT-97-0473
PRENDISENSOR
(1997-2000)

Prediction of the behaviour of potential endocrine disrupters in soils using vitellogenin ELISA assays as biosensors

Participating laboratories:
6 (PT, DE, NL, IT)
Coordinator:
Dr. Fernando Santana
Dept of Environmental Sciences and Engineering
Faculty of Sciences and Technology
New University of Lisbon
Quinta da Torre,
2825 Monte da Caparica, Portugal
Tel: + 351 1 2948397 
Fax: + 351 1 2948554

Biosensor development based on vitellogenin in fish

Project final report 
  PDF icon 17 KB

ENV-CT-98-0801
SANDRINE
2000-2002

Biosensor tracing of endocrine disrupting compounds in surface water, waste water and sludge for water quality assessment

Participating laboratories:
9 (DE, GB, CH, ES)
Coordinator:
Prof. Pieter-Diedrich Hansen
Dept Ecotoxicology
Institute for Ecology and Biology
Technical University of Berlin (TUB)
Keplerstrasse, 4-6
10589 Berlin, Germany
Tel: + 49 30 31421463
Fax: + 49 30 31421675
pd.hansen@tu-berlin.de

Behaviour of EDCs in wastewater plants; development of bioassays and biosensors

Project final report 
  PDF icon 137 KB

ENV4-CT-97-0581
EDAEP
1998-2000

Endocrine-disrupting ability of environmental pollutants

Participating laboratories:
8 (IT, GB, NL, SE, BG)
Coordinator:
Dr Erminio Marafante
European Commission
Environment Institute
European Chemicals Bureau
21020 Ispra Varese, Italy
Tel: +39 0332 78 9144                        
Fax: +39 0332 78 9328
erminio.marafante@jrc.it

Development and application of QSAR techniques to screen chemicals for ED potential

Project final report 
  PDF icon 18 KB

MAIN FINDINGS FROM FP4 projects
  • PCBs at current background levels are associated with subtle adverse effects on nervous system development resulting in cognitive, motor and neurological delay or deficit
  • Breastfeeding may counteract the adverse developmental effects of PCBs
  • The growing foetus and infants are at a higher risk from endocrine-disrupting effects of organohalogens than adult men and women
  • Halogenated phenolic pollutants or metabolites of persistent organic pollutants may have stronger implications as endocrine disrupters than yet recognised
  • A second receptor for estrogens (ERß) was cloned and characterised
  • Transgenic zebrafish can be used as a model to determine the effect of xeno-estrogens on reproductive organs
  • Oestrogens can cause lasting effects on zebrafish development and reproduction
  • Oestrogens have severe effects on sexual maturation by preventing normal pubertal testis development and onset of spermatogenesis in freshwater fish
  • Oestrogenic effluents are widespread in Europe and can influence fish individually and at population levels
  • Persistent organic pollutants (POPs) can cause deadly thiamin deficiency, killing offspring of guillemots and salmon in the Baltic Sea
  • PCBs can have an impact on the reproductive organs of cattle, goats and sheep
  • Behaviour of EDCs in wastewater plants has been investigated and models obtained
  • Dioxin and PCBs may induce tumour promotion in the liver of rats secondary to some sort of liver injury. Dioxin could not be shown to be a risk factor for soft-tissue sarcoma. The high frequency of hypomineralised dental defects in an ordinary child population could be a sign of exposure to dioxins. The dioxin receptor was cloned and characterised from rat
  • Tributylin and mercuric chloride decrease fertility in wild fish (decreased sperm motility) at environmentally relevant concentrations
  • There is a trend towards declining sperm counts in several European countries, possibly related to EDCs
  • A biosensor to measure vitellogenin in fish blood was developed.
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