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Cell factory press conference Graz, Austria – 29th October 1999

Project 6.

New methods of vaccine production

Porcine parvovirus (PPV) causes major reproductive problems in pigs that can lead to major economic losses for the pig industry. The disease is usually controlled by vaccination. The use of empty viral particles that perfectly mimic the original viral structures is becoming a popular approach in vaccinology. These virus-like particles (VLPs) are produced in insect cell factories. They are known to induce a strong immune response and can be used safely as vaccines. So the production of these empty particles in insect cells has proven to be a good method for the preparation of vaccines. Unfortunately, large-scale development of these vaccines has been hampered by the large costs and efforts associated with optimising the technology and getting regulatory approval.

The aim of this demonstration project is to demonstrate the economic viability of industrial production of VLPs for use as vaccines, taking PPV to obtain proof of concept for the system. The ultimate goal is develop a production process that is recognised for EC registration and should make the commercialisation of these safe new vaccines possible.

 

Project title: In vitro production and purification of Porcine Parvovirus-like particles
Coordinator: Dr. I. Casal, Ingenasa (ES).
Partners: 3 (ES, PT, NL) including one industrial partner.
Project type: Demonstration Start date: Sept. 1998 Duration: 24 months
Contract n: BIO4-CT980215 Total cost: 1 042 000 EC funding: 626 000

Photo 1.

thumb1.jpg (2620 bytes) "Electron micrograph of porcine parvovirus virus-like particles"
photo credit: Ingenasa SA

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Graz Conference | BIOTECH PROGRAMME | 18.02.2000

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