Knowledge Based Bio-Economy


Aggregate and cumulative risk of pesticides: An on-line integrated strategy (Food Quality and Safety)

Project acronym: ACROPOLIS

Title of project: Aggregate and cumulative risk of pesticides: An on-line integrated strategy

Research area: Food Quality and Safety

Contract No: 245163

EU contribution: €2 995 548

Start date: June 2010

Duration: 42 months

Status: on-going

Current risk assessment of pesticides and MRL setting does not sufficiently account for cumulative and aggregate exposure (Regulation (EC) 396/2005). The overall objective of the project ACROPOLIS is to improve risk assessment strategies in Europe. The specific objectives of the project, which will be addressed in five specific work packages, are:

  • improved cumulative exposure assessment and cumulative hazard assessment methodology;
  • new models for aggregated exposure assessment addressing different routes of exposure;
  • setting up new toxicological testing for identifying possible synergistic effects and developing a strategy for refinement of cumulative assessment groups;
  • integrating cumulative and aggregate risk models integrated in a web-based tool, including accessible data for all stakeholders;
  • improving the understanding of cumulative risk assessment methodology of different stakeholders.

Cumulative pesticide risk assessment is a multi-stakeholder issue. European consumer groups have raised their concern and the pesticide industry has an urgent need for clear criteria in order to justify the enormous investments in producing new pesticides. The ACROPOLIS project will therefore organise stakeholder conferences to address the complex issue of cumulative and aggregate risk assessment, and the usability and user-friendliness of the models will be tested.

The project will develop a framework for cumulative and aggregate risk assessment of pesticides, which is scientifically sound and accessible for all actors involved in the European risk assessment and risk management. The project brings together the key experts and models in Europe including dietary exposure MCRA, dermal and inhalation exposure ConsExpo, user exposure EUROPOEM and UK POEM, dose-response PROAST, and risk characterisation IPRA. The new integrated model will be tested in case studies with conazoles, and will be validated with biomarker and duplicate diet studies. The model software will be tested in different countries to ensure its usability on an international level.

Website of project:

Coordinator: Jacob van Klaveren,

Organisation: National Institute for Public Health and the Environment, The Netherlands,